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Role of homocysteine in the development and progression of Parkinson’s disease

open access: yesAnnals of Clinical and Translational Neurology, 2020
Homocysteine is an essential intermediate product of biochemical reactions that is present in various tissues of the human body. Homocysteine may be associated with the development and progression of Parkinson’s disease.
Xiaoyan Fan   +6 more
doaj   +2 more sources

Association Between Homocysteine and Vascular Calcification Incidence, Prevalence, and Progression in the MESA Cohort [PDF]

open access: yesJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background While elevated homocysteine has been associated with calcification in several studies, its importance as a cardiovascular risk factor remains unclear.
Amy B. Karger   +7 more
doaj   +3 more sources

Plasma Homocysteine Levels and Mortality in Patients with Coronary Artery Disease [PDF]

open access: bronzeNew England Journal of Medicine, 1997
BACKGROUND Elevated plasma homocysteine levels are a risk factor for coronary heart disease, but the prognostic value of homocysteine levels in patients with established coronary artery disease has not been defined.
Ottar Nygård   +5 more
openalex   +2 more sources

Homocysteine and vascular disease

open access: yesThe Lancet, 1999
For more than 20 years, moderately raised concentrations of total homocysteine have been associated with an increased risk of atherothrombotic vascular events but only recently has evidence mounted to suggest that the association may be causal. The association is independent of other factors, it is fairly consistent across many studies, it is strong ...
Graeme J. Hankey, John W. Eikelboom
openaire   +5 more sources

Homocysteine – from disease biomarker to disease prevention

open access: yesJournal of Internal Medicine, 2021
We have reviewed the literature and have identified more than 100 diseases or conditions that are associated with raised concentrations of plasma total homocysteine.
A. Smith, H. Refsum
semanticscholar   +1 more source

Homocysteine Metabolism in Pregnancy and Developmental Impacts

open access: yesFrontiers in Cell and Developmental Biology, 2022
Homocysteine is a metabolite generated by methionine cycle metabolism, comprising the demethylated derivative of methionine. Homocysteine can be metabolised by the transsulphuration pathway to cystathionine, which requires vitamin B6, or can undergo ...
Stephen W. D’Souza, Jocelyn D. Glazier
doaj   +1 more source

Homocysteine levels correlate with AVSS-RigiScan test parameters in men with erectile dysfunction

open access: yesBasic and Clinical Andrology, 2023
Background Although elevated homocysteine levels have been shown to affect penile erection, the relationship between homocysteine and erection at the tip or base of the penis has not been extensively studied.
Xin Qian   +5 more
doaj   +1 more source

Ability of dietary factors to affect homocysteine levels in mice: a review

open access: yesNutrition & Metabolism, 2021
Homocysteine is associated with several diseases, and a series of dietary factors are known to modulate homocysteine levels. As mice are often used as model organisms to study the effects of dietary hyperhomocysteinemia, we collected data about ...
Christine Brütting   +3 more
doaj   +1 more source

Homocysteine inhibits hepatocyte proliferation via endoplasmic reticulum stress. [PDF]

open access: yesPLoS ONE, 2013
Homocysteine is an independent risk factor for coronary, cerebral, and peripheral vascular diseases. Recent studies have shown that levels of homocysteine are elevated in patients with impaired hepatic function, but the precise role of homocysteine in ...
Xue Yu   +4 more
doaj   +1 more source

The homocysteine controversy [PDF]

open access: yesJournal of Inherited Metabolic Disease, 2010
AbstractMild to moderate hyperhomocysteinemia has been identified as a strong predictor of cardiovascular disease, independent from classical atherothrombotic risk factors. In the last decade, a number of large intervention trials using B vitamins have been performed and have shown no benefit of homocysteine‐lowering therapy in high‐risk patients.
Smulders, Y.M., Blom, H.J.
openaire   +4 more sources

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