Results 41 to 50 of about 90,248 (215)

Homocysteine is a bystander for ST-segment elevation myocardial infarction: a case-control study

BMC Cardiovascular Disorders, 2018
Background Homocysteine has been long considered a risk factor for atherosclerosis. However, cardiovascular events cannot be reduced through homocysteine lowering by B vitamin supplements.
Ching-Yu Julius Chen, Tzu-Ching Yang, Christopher Chang, Shao-Chun Lu, Po-Yuan Chang   +4 more
doaj   +1 more source

Endoplasmic reticulum stress mediates homocysteine-induced hypertrophy of cardiac cells through activation of cyclic nucleotide phosphodiesterase 1C

Acta Biochimica et Biophysica Sinica, 2022
Although the association of elevated homocysteine level with cardiac hypertrophy has been reported, the molecular mechanisms by which homocysteine induces cardiac hypertrophy remain inadequately understood.
Sun Wentao, Zhou Yang, Xue Hongmei, Hou Haitao, He Guowei, Yang Qin   +5 more
doaj   +1 more source

Blood‐Based Biomarkers in Alzheimer's Disease: Advances in Detection Technologies and Clinical Applications

AGING MEDICINE, EarlyView.
Blood‐based biomarkers are emerging as accessible tools for Alzheimer's disease screening, diagnosis, risk stratification, and longitudinal monitoring. This review summarizes major biomarkers, including Aβ42/Aβ40, phosphorylated tau species, NfL, GFAP, genetic risk markers, and exploratory inflammatory, synaptic, and proteomic candidates.
Shuangshuang Li, Lin Huang, Qihao Guo
wiley   +1 more source

Generation and initial characterization of a novel polyclonal antibody directed against homocysteine thiolactone-modified low density lipoprotein

Journal of Lipid Research, 1998
Elevated plasma homocysteine (homocysteinemia) are presumed to be responsible for the development of coronary artery disease, however, the precise etiology is unclear.
Eric Ferguson, Sampath Parthasarathy, Joy Joseph, B. Kalyanaraman   +3 more
doaj   +1 more source

Increased Plasma Homocysteine Levels Are Associated with Left Ventricular Hypertrophy in Hypertensive Patients with Normal Renal Function

Kidney & Blood Pressure Research, 2023
Introduction: Renal function has an important bearing on plasma homocysteine levels. Plasma homocysteine is related to left ventricular hypertrophy (LVH).
Lingyu Zhang, Tingjun Wang, Yihua Shen, Li Luo, Guoyan Xu, Liangdi Xie   +5 more
doaj   +1 more source

Elevated Levels of Methylmalonate and Homocysteine in Parkinson's Disease, Progressive Supranuclear Palsy and Amyotrophic Lateral Sclerosis [PDF]

, 2010
Background/Aims: Increasing evidence suggests that elevated levels of homocysteine (Hcy) and methylmalonate (MMA) may be involved in the pathogenesis of neurodegenerative diseases. Methods: The urine levels of MMA and serum levels of Hcy as well as folic
Armin Giese, Michael Vogeser, Levin, Johannes, Bötzel, Kai, Kai Bötzel, Vogeser, Michael, Johannes Levin, Lorenzl, Stefan, Stefan Lorenzl, Giese, Armin   +9 more
core   +1 more source

Homocysteine-mediated inhibition of leptin-induced STAT3 transcriptional activity assessed by STAT3 reporter gene assay.

, 2022
SH-SY5Y-Ob-Rb cells transfected with the STAT3-promoter-Nluc construct were treated with homocysteine (Hcy; 1–10 mM) and leptin (Lep; 0.01 μg/mL), and the luminescence signal is measured 4 hours after treatments.
Michiko Yoshii (14253351), Arini Isnani Preninka (14253342), Kyosuke Yazawa (14253348), Toru Hosoi (154313), Yuhki Yanase (3960317), Ralf Jockers (245630), Julie Dam (8208489), Karen Kuriya (14253345), Koichiro Ozawa (154324)   +8 more
core   +1 more source

Homocysteine-induced endothelial dysfunction through mediating endoplasmic reticulum stress

Journal of International Medical Research
Objective Endothelial dysfunction is a key pathological process in cardiovascular and cerebrovascular diseases. Herein, we aimed to investigate the effect of homocysteine on endoplasmic reticulum stress in a model of endothelial dysfunction, focusing on ...
Xiaoxue Zhang, Shengtao Xiong, Liang Long, Yue Xuan, Hongjing You, Yue Xu, Minyi Zhang   +6 more
doaj   +1 more source

Beyond Protein Synthesis: The Multifunctional Role of Functional Amino Acids in Modulating Meat Quality in Ruminants

Animal Research and One Health, EarlyView.
Multifunctional roles of functional amino acids in regulating meat quality in ruminants: Functional amino acids (FAAs) regulate ruminant meat quality through multiple interconnected mechanisms, including antioxidant protection, metabolic regulation, signal transduction, structural support, and gene expression modulation.
Zixin Liu, Tian Xia, Xiaokang Lv, Man Ren, Chuanshe Zhou, Zhiliang Tan   +5 more
wiley   +1 more source

Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials.

, 2005
BACKGROUND: Dietary supplementation with B vitamins that lower blood homocysteine concentrations is expected to reduce cardiovascular disease risk, but there has been uncertainty about the optimum regimen to use for this purpose.
Homocysteine Lowering Trialists' Collaboration
core   +1 more source