Results 51 to 60 of about 87,836 (275)

An Enzymatic Platform for Late‐Stage (Radio)isotope Labelling of Oligonucleotides With Methyltransferases

Angewandte Chemie, EarlyView.
State‐of‐the‐art synthesis of radiolabelled oligonucleotides involves multi‐step synthesis with high costs, extended timelines and significant radioactive waste generation. Herein, a dual‐methyltransferase platform enables late‐stage, site‐specific labelling, overcoming these limitations through reduced costs, faster turnaround and minimal radioactive ...
Christopher R. B. Swanson, Ulrich Kauhl, Martin R. Edelmann, Florian P. Seebeck   +3 more
wiley   +2 more sources

The Association between Homocysteine, Arterial Stiffness and Executive Function Middle-age and Older Women

Artery Research, 2020
Age-related decreases in executive function and an increase in arterial stiffness and plasma homocysteine levels are related to the risk of dementia. However, the association between executive function, arterial stiffness, and homocysteine levels remains
Ai Shindo-Hamasaki, Nobuhiko Akazawa, Reiko Momma, Seiji Maeda   +3 more
doaj   +1 more source

Homocysteine Metabolism

YAKUGAKU ZASSHI, 2007
Homocysteine, a sulfur amino acid, is an intermediate metabolite of methionine. In 1969, McCully reported autopsy evidence of extensive arterial thrombosis and atherosclerosis in children with elevated plasma homocysteine concentrations and homocystinuria.
Takao, Hashimoto, Yoshihiko, Shinohara, Hiroshi, Hasegawa   +2 more
openaire   +3 more sources

Homocysteine-induced endoplasmic reticulum stress.

, 2022
(A-D) SHY5Y-Ob-R cells were treated with homocysteine (Hcy), methionine (Met), and cysteine (Cys) for 4 and 8 hours at 10 mM, and the expression level of ER stress response gene, HERP, was analyzed by Dunnett test. *p 0.05, n = 5.
Michiko Yoshii (14253351), Arini Isnani Preninka (14253342), Kyosuke Yazawa (14253348), Toru Hosoi (154313), Yuhki Yanase (3960317), Ralf Jockers (245630), Julie Dam (8208489), Karen Kuriya (14253345), Koichiro Ozawa (154324)   +8 more
core   +1 more source

Coordination‐Modulated Catalytic Pathways at Carbon Dots‐Supported Single‐Atom Sites Revealed by Thiol Interactions

Advanced Functional Materials, EarlyView.
Carbon dots‐supported single‐atom catalysts provide a model platform for uncovering how coordination interactions regulate catalytic reactivity. Thiol binding at Ru‒N4 centers reshapes the reaction energy landscape of H2O2 activation, dynamically modulating ROS‐generation pathways through electronic‐structure perturbation.
Yihong Chen, Li Zhang, Qian Dong, Qingshi Liu, Kun Wang, Huiping Wang, Shaomin Shuang, Chuan Dong, Jin‐Chang Guo, Xiaojuan Gong, Zhuo Chen, Yingfu Li   +11 more
wiley   +1 more source

Endoplasmic reticulum stress mediates homocysteine-induced hypertrophy of cardiac cells through activation of cyclic nucleotide phosphodiesterase 1C

Acta Biochimica et Biophysica Sinica, 2022
Although the association of elevated homocysteine level with cardiac hypertrophy has been reported, the molecular mechanisms by which homocysteine induces cardiac hypertrophy remain inadequately understood.
Sun Wentao, Zhou Yang, Xue Hongmei, Hou Haitao, He Guowei, Yang Qin   +5 more
doaj   +1 more source

Statins and homocysteine

Atherosclerosis, 2003
Atherosclerosis
Miltiadous, G., Papakostas, J., Chasiotis, G., Seferiadis, K., Elisaf, M. S.   +4 more
openaire   +3 more sources

The concentration of homocysteine-derived disulfides in human coronary artery [PDF]

, 2007
*Background* Based on previous findings, we have estimated that, in injured coronary artery tissue, the low molecular weight disulfides homocystine and cysteine-homocysteine, otherwise identified as oxidized homocysteine equivalents (OHcyE ...
Liberato Ciavatta, Mauro Iuliano, Raffaele Ragone, Gaetano De Tommaso   +3 more
core  

B vitamins in patients with recent transient ischaemic attack or stroke in the VITAmins TO Prevent Stroke (VITATOPS) trial:a randomised, double-blind, parallel, placebo-controlled trial [PDF]

, 2010
Epidemiological studies suggest that raised plasma concentrations of total homocysteine might be a risk factor for major vascular events. Whether lowering total homocysteine with B vitamins prevents major vascular events in patients with previous stroke ...
Hankey, G.J., Jamrozik, K., Klijn, C.J., van Bockxmeer, F. M., Hill, M., Gelavis, A., Ferro, J., Lisheng, L., Wong, L., Uddin, W., Eikelboom, J. W., Tan, K., Divjak, I., Baker, R.I., de Freitas, G., Wong, M. C., Eikelboom, J.W., Navarro, J., Slivka, A., Tsiskaridze, A., Lees, K. R., Algra, A., Yi, Q., Ricci, S., Chen, C., Dennis, Martin, Hankey, G. J., Baker, R. I., ?, ?, Groppa, S., Hickling, S. C., Cheung, R., Gommans, J., Spence, J. D., Schmidt, R., Ranawaka, U., Vasikaran, S., et al.   +37 more
core   +1 more source

An Efficient Detection Platform Based on Mesoporous Au@Cr2O3 Particles with Schwarz P Surface for Precise Periodontitis Metabolite Profiling

Advanced Science, EarlyView.
A non‐invasive periodontitis diagnosis platform was developed using Au nanoparticles‐decorated mesoporous Cr2O3 (Au@mCr2O3) particles with Schwarz P surface as matrix for saliva metabolic fingerprinting (SMFs) analysis via MALDI‐MS. With the assistance of machine learning of SMFs, this platform enables efficient diagnosis and the screening of potential
Yue Sun, Yan Wang, Fangying Shi, Wenhe Xie, Yiding Zhang, Heyuhan Zhang, Chunhui Deng, Limin Wu, Meihua Chen, Yonghui Deng   +9 more
wiley   +1 more source