Results 61 to 70 of about 57,118 (176)
ABSTRACT Background Nutraceutical supplementation targeting mitochondrial function has been proposed as a beneficial therapeutic strategy to improve physical and mental health in psychiatric patients. Aims To summarise the results of studies evaluating nutraceutical supplementation targeting mitochondrial function in patients with psychiatric disorders.
Juan Tortajada +9 more
wiley +1 more source
ABSTRACT Background and Purpose The systemic inflammatory response, quantified by the neutrophil‐to‐lymphocyte ratio (NLR), and central neuronal injury, reflected by serum neuron‐specific enolase (NSE), are implicated in the pathogenesis of acute ischemic stroke (AIS).
Ning Rong +8 more
wiley +1 more source
Heme Metabolism‐Derived Carbon Monoxide Regulates Skeletal Muscle Function
ABSTRACT Background Heme oxygenases, HO‐1 (Hmox1) and HO‐2 (Hmox2), regulate skeletal muscle homeostasis by degrading heme and generating carbon monoxide (CO), a bioactive signalling molecule. Although HO‐1 is known to influence muscle fibre composition and mitochondrial function, the role of HO‐2 in activity‐dependent neuromuscular plasticity remains ...
Rodrigo W. Alves de Souza +8 more
wiley +1 more source
ABSTRACT Objective Venous thromboembolism (VTE) is a leading cause of preventable perioperative mortality in otolaryngology, highlighting the urgent need for validated risk assessments such as the Caprini score to guide prophylaxis and enhance patient safety.
Corinne A. Pittman +5 more
wiley +1 more source
The Role of N6‐Methyladenosine Modification in Health and Disease
N6‐methyladenosine (m6A) is the most prevalent internal RNA modification in eukaryotes, acting as a pivotal epitranscriptomic regulator of RNA metabolism. This modification plays a dual role: it maintains physiological homeostasis under normal conditions but drives disease progression when dysregulated.
Linghuan Li +6 more
wiley +1 more source
Nonlinear relationship between circulating homocysteine and parathyroid hormone among patients with osteoporotic fractures: A cross-sectional study based on a hospital cohort. [PDF]
Wang JH +5 more
europepmc +1 more source
Diabetic Peripheral Neuropathy: Molecular Staging, Risk Factors, Therapeutics, and Emerging Trends
The heterogeneous landscape of DPN can be unified through a tripartite pathogenic model encompassing progressive stages of metabolic dysregulation, chronic inflammation, and overt neuronal damage. Within this framework, six clinical subtypes were identified, namely, hyperglycemia‐driven, dyslipidemia‐driven, inflammation‐driven, dysvascularity‐driven ...
Xiaofeng Dai, Mingze Tang
wiley +1 more source
Sulfur-Containing Amino Acids: The Conversion Process from Product to Substrate. [PDF]
Zheng P, Jin Y, Wei C, Xia C.
europepmc +1 more source
Oxidative Stress and DNA Epigenetic Modifications in Cancer: Mechanisms and Targeted Therapeutics
Reactive oxygen species (ROS) modulate DNA methyltransferases (DNMTs), ten‐eleven translocation family proteins (TETs) and their cofactors, reshaping 5‐methylcytosine (5mC)/5‐hydroxymethylcytosine (5hmC)/5‐formylcytosine (5fC) landscapes and gene expression in cancer cells. In turn, epigenetic control of antioxidant and metabolic pathways feeds back on
Xishan Yang +7 more
wiley +1 more source
Predicting late radiation-associated neurocognitive and endocrine toxicity in patients with brain tumors. [PDF]
Tuohy K +7 more
europepmc +1 more source

