Results 21 to 30 of about 87,836 (275)

Homocysteine and psoriasis [PDF]

Bioscience Reports, 2019
AbstractPsoriasis is caused by a complex interplay among the immune system, genetic background, autoantigens, and environmental factors. Recent studies have demonstrated that patients with psoriasis have a significantly higher serum homocysteine (Hcy) level and a higher prevalence of hyperhomocysteinaemia (HHcy). Insufficiency of folic acid and vitamin
Xiran Lin, Xianmin Meng, Zhiqi Song
openaire   +2 more sources

Estrogen and homocysteine [PDF]

Cardiovascular Research, 2002
Cardiovascular diseases are the major causes of illness and death in women. Premenopausal women are relatively protected from coronary artery disease and atherosclerosis as compared to postmenopausal women, and this protection is attributed to the effects of the female sex hormone (estrogen). The vasculature, like the reproductive tissues, bone, liver,
Kamellia R, Dimitrova, Kerry, DeGroot, Adam K, Myers, Young D, Kim   +3 more
openaire   +2 more sources

Elevated plasma homocysteine upon ischemic stroke is associated with increased long-term mortality in women. [PDF]

PLoS ONE, 2017
Ischemic stroke is a leading cause of death worldwide, despite preventive and therapeutic advances during the last twenty years. Blood-borne biomarkers have been studied in association to short- and long-term outcome, in order to investigate possible ...
Ioanna Markaki, Stefanos Klironomos, Konstantinos Kostulas, Christina Sjostrand   +3 more
doaj   +1 more source

Apoptosis of bone marrow mesenchymal stem cells caused by homocysteine via activating JNK signal. [PDF]

PLoS ONE, 2013
Bone marrow mesenchymal stem cells (BMSCs) are capable of homing to and repair damaged myocardial tissues. Apoptosis of BMSCs in response to various pathological stimuli leads to the attenuation of healing ability of BMSCs.
Benzhi Cai, Xingda Li, Yang Wang, Yanju Liu, Fan Yang, Hongyang Chen, Kun Yin, Xueying Tan, Jiuxin Zhu, Zhenwei Pan, Baoqiu Wang, Yanjie Lu   +11 more
doaj   +1 more source

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source

Proteogenomic characterization of cholangiocarcinoma

Hepatology, EarlyView., 2022
Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng, Peng Ran, Lingli Chen, Yunzhi Wang, Zixiang Yu, Ke Cai, Jinwen Feng, Zhaoyu Qin, Yanan Yin, Subei Tan, Yang Liu, Chen Xu, Guoming Shi, Yuan Ji, Jian‐Yuan Zhao, Jian Zhou, Jia Fan, Yingyong Hou, Chen Ding   +18 more
wiley   +1 more source

The homocysteine controversy [PDF]

Journal of Inherited Metabolic Disease, 2010
AbstractMild to moderate hyperhomocysteinemia has been identified as a strong predictor of cardiovascular disease, independent from classical atherothrombotic risk factors. In the last decade, a number of large intervention trials using B vitamins have been performed and have shown no benefit of homocysteine‐lowering therapy in high‐risk patients.
Smulders, Y.M., Blom, H.J.
openaire   +4 more sources

Influence of hyperhomocysteinemia on the cellular redox state - Impact on homocysteine-induced endothelial dysfunction [PDF]

, 2003
Hyperhomocysteinemia is an independent risk factor for the development of atherosclerosis. An increasing body of evidence has implicated oxidative stress as being contributory to homocysteines deleterious effects on the vasculature.
Keaney, John F., Weiss, Norbert, Postea, Otilia, Heydrick, Stanley J., Keller, Christiane, Loscalzo, Joseph   +5 more
core   +1 more source

Role of homocysteine in the development and progression of Parkinson’s disease

Annals of Clinical and Translational Neurology, 2020
Homocysteine is an essential intermediate product of biochemical reactions that is present in various tissues of the human body. Homocysteine may be associated with the development and progression of Parkinson’s disease.
Xiaoyan Fan, Lixia Zhang, Haijun Li, Guang Chen, Gangqiao Qi, Xueqiang Ma, Yuelei Jin   +6 more
doaj   +1 more source

Creutzfeldt-Jakob disease and homocysteine levels in plasma and cerebrospinal fluid [PDF]

, 2005
Background: There is evidence that homocysteine contributes to various neurodegenerative disorders. Objective: To assess the values of homocysteine in patients with Creutzfeldt-Jakob disease (CJD) in both cerebrospinal fluid (CSF) and plasma.
Bleich, S., Kropp, S., Wiltfang, J., Zerr, Inga, Zerr, I., Kretzschmar, Hans A., Kropp, Silke, Otto, Markus, Wiltfang, Jens, Bleich, Stefan   +9 more
core   +1 more source