Results 21 to 30 of about 61,908 (219)
The homocysteine controversy [PDF]
Journal of Inherited Metabolic Disease, 2010 AbstractMild to moderate hyperhomocysteinemia has been identified as a strong predictor of cardiovascular disease, independent from classical atherothrombotic risk factors. In the last decade, a number of large intervention trials using B vitamins have been performed and have shown no benefit of homocysteine‐lowering therapy in high‐risk patients.
Smulders, Y.M., Blom, H.J.
openaire +4 more sources
NF-kappaB activation is associated with homocysteine-induced injury in Neuro2a cells
BMC Neuroscience, 2008 Background Perinatal exposure to hyperhomocysteinemia might disturb neurogenesis during brain development and growth. Also, high levels of homocysteine trigger neurodegeneration in several experimental models.
Ientile Riccardo +5 more
doaj +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020 Background While elevated homocysteine has been associated with calcification in several studies, its importance as a cardiovascular risk factor remains unclear.
Amy B. Karger +7 more
doaj +1 more source
Homocysteine: A Potential Common Route for Cardiovascular Risk and DNA Methylation in Psoriasis
Chinese Medical Journal, 2017 Objective: Homocysteine is a sulfur-containing amino acid with potential clinical significance. Abnormal homocysteine levels have been found in patients with psoriasis.
Wen-Ming Wang, Hong-Zhong Jin
doaj +1 more source
Homocysteine causes neuronal leptin resistance and endoplasmic reticulum stress
PLoS ONE, 2022 Abnormally high serum homocysteine levels have been associated with several disorders, including obesity, cardiovascular diseases or neurological diseases.
Arini Isnani Preninka +8 more
doaj
Potential Antioxidative Activity of Homocysteine in Erythrocytes under Oxidative Stress
Antioxidants, 2023 Homocysteine is an amino acid containing a free sulfhydryl group, making it probably contribute to the antioxidative capacity in the body. We recently found that plasma total homocysteine (total-Hcy) concentration increased with time when whole blood ...
Mingxin Ye +5 more
doaj +1 more source
Homocysteine homeostasis and betaine-homocysteine S-methyltransferase expression in the brain of hibernating bats. [PDF]
PLoS ONE, 2013 Elevated homocysteine is an important risk factor that increases cerebrovascular and neurodegenerative disease morbidity. In mammals, B vitamin supplementation can reduce homocysteine levels.
Yijian Zhang +4 more
doaj +1 more source
Angewandte Chemie, EarlyView.State‐of‐the‐art synthesis of radiolabelled oligonucleotides involves multi‐step synthesis with high costs, extended timelines and significant radioactive waste generation. Herein, a dual‐methyltransferase platform enables late‐stage, site‐specific labelling, overcoming these limitations through reduced costs, faster turnaround and minimal radioactive ...
Christopher R. B. Swanson +3 more
wiley +2 more sources
Angewandte Chemie, EarlyView.Re‐envisioning the Ligandable Proteome: Reactive Metallo‐Scaffolds (r‐mS) combine non‐covalent protein engagement by a metallo‐scaffold with covalent cysteine capture through a tethered chloroacetamide warhead. Chemoproteomic profiling reveals unique enzyme engagement including ligases, kinases and methyltransferases, highlighting opportunities for ...
Jessica E. Waters +15 more
wiley +2 more sources
Artery Research, 2020 Age-related decreases in executive function and an increase in arterial stiffness and plasma homocysteine levels are related to the risk of dementia. However, the association between executive function, arterial stiffness, and homocysteine levels remains
Ai Shindo-Hamasaki +3 more
doaj +1 more source