Results 101 to 110 of about 90,248 (215)

Article Commentary: Retinal Ganglion Cell Loss in Diabetes Associated with Elevated Homocysteine

Ophthalmology and Eye Diseases, 2009
A number of studies have suggested that homocysteine may be a contributing factor to development of retinopathy in diabetic patients based on observed correlations between elevated homocysteine levels and the presence of retinopathy.
Kenneth S. Shindler
doaj   +1 more source

Emerging insights into amino acid metabolism in the heart: implications for cardiovascular diseases and therapeutic targeting

British Journal of Pharmacology, EarlyView.
As a metabolically versatile organ, the heart is capable of generating energy from a wide range of substrates. Although fatty acid and glucose metabolism in the heart have been extensively studied, the contribution of amino acid metabolism to cardiac physiology and disease is gaining increasing attention.
Tayyiba Azam, Hongyuan Zhang, Min Zi, Chen Chen, Junfang Wu, Andreas Papapetropoulos, Xin Wang   +6 more
wiley   +1 more source

Is There Any Difference in the Plasma Homocysteine Levels of Diabetes Mellitus Type Ii Patients, Impaired Glucose Tolerance Subjects and Normal People?

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2005
Introduction: Hyperhomocysteinemia is associated with an increased risk of cardiovascular disease in diabetic patients. The aim of this study was to determine plasma homocysteine levels in diabetics and compare with control persons and also evaluation of
M Amini, A Kachoie, H Rezvanian, A Amin-Alroaaya, M Mohammadi   +4 more
doaj  

Mechanism of action and impact of thiol homeostasis on efficacy of an enzyme replacement therapy for classical homocystinuria

Redox Biology
Homocystinuria (HCU) due to cystathionine beta-synthase (CBS) deficiency is characterized by elevated plasma and tissue homocysteine levels. There is no cure, but HCU is typically managed by methionine/protein restriction and vitamin B6 supplementation ...
Thilo Magnus Philipp, Teodoro Bottiglieri, Wilmelenne Clapper, Kai Liu, Steve Rodems, Csaba Szabo, Tomas Majtan   +6 more
doaj   +1 more source

Homocysteine and methionine metabolism in renal failure

, 2005
Renal insufficiency is invariably accompanied by elevated plasma concentrations of the sulfur-containing and potentially vasculotoxic amino acid homocysteine.
Stehouwer, C.D.; id_orcid, van Guldener, C.   +1 more
core   +1 more source

S‐Adenosylmethionine (SAM) hydrolases counter increased SAM epimerisation in thermophilic archaea

The FEBS Journal, EarlyView.
S‐Adenosyl‐l‐methionine (SAM) is a vital enzyme cofactor. Epimerisation at the sulfonium centre of biologically active (SS,SCα)‐SAM is driven by heat, yielding biologically inactive (RS,SCα)‐SAM. Here, two novel archaeal SAM hydrolases from the thermophilic Sulfolobus acidocaldarius and the halophilic Haloferax volcanii are shown to cleave (RS,SCα)‐SAM.
Agnes Bartels, Michael K. F. Mohr, Phillip Nußbaum, Marie Joest, Bianca Wassmer, Laurent Rasquin, Sonja‐Verena Albers, Jennifer N. Andexer   +7 more
wiley   +1 more source

A Rabbit Model of Hyperhomocysteinemia:The Effect of Homocysteine on Blood Clot Structure and Stability

, 2004
Hyperhomocysteinemia(Hhcys) is a condition that several epidemiological studies have shown to be associated with atherosclerosis and thrombosis, due to an elevation of plasma homocysteine levels.
Sauls, Derrick Lamonte
core  

Superoxide-dependent cerebrovascular effects of homocysteine

, 1998
Recent evidence indicates that elevated plasma levels of homocysteine are a risk factor for ischemic cerebrovascular diseases. However, little is known about cerebrovascular effects of homocysteine.
Gregory M. Vercellotti, Costantino Iadecola, Arne Slungaard, Fangyi Zhang   +3 more
core   +1 more source

Biocatalytic synthesis of S‐adenosyl‐l‐methionine analogues for allosteric activation of cystathionine‐β‐synthase

The FEBS Journal, EarlyView.
Cystathionine‐β‐synthase (CBS) helps remove harmful homocysteine and supports the production of protective sulfur‐containing molecules. Using its natural activator, S‐adenosyl‐l‐methionine, as a template, we designed and tested 15 analogues. Three activated and stabilized the enzyme, including the newly identified S‐2‐amino‐adenosyl‐l‐methionine. These
Dalibor Nakládal, Žaneta Zajacová, Rick Oerlemans, Jana Havlikova, Gabriel Zorkócy, Lukáš Kerti, Katarína Sujová, Adrian Lengyel, Zoë van der Gun, Christina Yoseif, Adrianus Cornelis van der Graaf, Guido Krenning, Ján Kyselovič, Vladimír Frecer, Matthew R. Groves, Zdenko Levarski, André Heeres, Rob H. Henning, Leo E. Deelman   +18 more
wiley   +1 more source

Homocysteine metabolism.

, 2013
Homocysteine is metabolized to methionine by remethylation and cystathionine by transsulfuration. Coenzymes are shown in gray. BHMT, betaine-homocysteine S-methyltransferase; DMG, dimethylglycine; MAT, methionine adenosyltransferase; SAM, S ...
Lina Wang (44695), Yi-Hsuan Pan (404765), Yijian Zhang (404766), Tengteng Zhu (501315), Shuyi Zhang (34553)   +4 more
core   +1 more source