Results 11 to 20 of about 76,480 (215)

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source

Homocysteine and familial longevity: the Leiden Longevity Study.

PLoS ONE, 2011
Homocysteine concentrations are a read-out of methionine metabolism and have been related to changes in lifespan in animal models. In humans, high homocysteine concentrations are an important predictor of age related disease.
Carolien A Wijsman, Diana van Heemst, Maarten P Rozing, P Eline Slagboom, Marian Beekman, Anton J M de Craen, Andrea B Maier, Rudi G J Westendorp, Henk J Blom, Simon P Mooijaart   +9 more
doaj   +1 more source

Proteogenomic characterization of cholangiocarcinoma

Hepatology, EarlyView., 2022
Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng, Peng Ran, Lingli Chen, Yunzhi Wang, Zixiang Yu, Ke Cai, Jinwen Feng, Zhaoyu Qin, Yanan Yin, Subei Tan, Yang Liu, Chen Xu, Guoming Shi, Yuan Ji, Jian‐Yuan Zhao, Jian Zhou, Jia Fan, Yingyong Hou, Chen Ding   +18 more
wiley   +1 more source

NF-kappaB activation is associated with homocysteine-induced injury in Neuro2a cells

BMC Neuroscience, 2008
Background Perinatal exposure to hyperhomocysteinemia might disturb neurogenesis during brain development and growth. Also, high levels of homocysteine trigger neurodegeneration in several experimental models.
Ientile Riccardo, Parisi Giulia, Currò Monica, Condello Salvatore, Ferlazzo Nadia, Caccamo Daniela   +5 more
doaj   +1 more source

Endoplasmic reticulum stress mediates homocysteine-induced hypertrophy of cardiac cells through activation of cyclic nucleotide phosphodiesterase 1C

Acta Biochimica et Biophysica Sinica, 2022
Although the association of elevated homocysteine level with cardiac hypertrophy has been reported, the molecular mechanisms by which homocysteine induces cardiac hypertrophy remain inadequately understood.
Sun Wentao, Zhou Yang, Xue Hongmei, Hou Haitao, He Guowei, Yang Qin   +5 more
doaj   +1 more source

Importance of Raised Serum Homocysteine Levels in Ischemic Stroke Patients [PDF]

Liaquat National Journal of Primary Care
Background: Around 5.5 million people die from stroke each year, making it the second leading cause of mortality worldwide. Increased homocysteine levels lead to early neurological deteriorations in ischemic stroke and may have an association with other
Rida Batool, Syeda Nosheen Zehra
doaj   +1 more source

Association Between Homocysteine and Vascular Calcification Incidence, Prevalence, and Progression in the MESA Cohort

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background While elevated homocysteine has been associated with calcification in several studies, its importance as a cardiovascular risk factor remains unclear.
Amy B. Karger, Brian T. Steffen, Sarah O. Nomura, Weihua Guan, Parveen K. Garg, Moyses Szklo, Matthew J. Budoff, Michael Y. Tsai   +7 more
doaj   +1 more source

Increased Plasma Homocysteine Levels Are Associated with Left Ventricular Hypertrophy in Hypertensive Patients with Normal Renal Function

Kidney & Blood Pressure Research, 2023
Introduction: Renal function has an important bearing on plasma homocysteine levels. Plasma homocysteine is related to left ventricular hypertrophy (LVH).
Lingyu Zhang, Tingjun Wang, Yihua Shen, Li Luo, Guoyan Xu, Liangdi Xie   +5 more
doaj   +1 more source

Homocysteine causes neuronal leptin resistance and endoplasmic reticulum stress

PLoS ONE, 2022
Abnormally high serum homocysteine levels have been associated with several disorders, including obesity, cardiovascular diseases or neurological diseases.
Arini Isnani Preninka, Karen Kuriya, Kyosuke Yazawa, Michiko Yoshii, Yuhki Yanase, Ralf Jockers, Julie Dam, Toru Hosoi, Koichiro Ozawa   +8 more
doaj  

Homocysteine: A Potential Common Route for Cardiovascular Risk and DNA Methylation in Psoriasis

Chinese Medical Journal, 2017
Objective: Homocysteine is a sulfur-containing amino acid with potential clinical significance. Abnormal homocysteine levels have been found in patients with psoriasis.
Wen-Ming Wang, Hong-Zhong Jin
doaj   +1 more source