Results 21 to 30 of about 143,735 (277)

Elevated plasma homocysteine upon ischemic stroke is associated with increased long-term mortality in women. [PDF]

PLoS ONE, 2017
Ischemic stroke is a leading cause of death worldwide, despite preventive and therapeutic advances during the last twenty years. Blood-borne biomarkers have been studied in association to short- and long-term outcome, in order to investigate possible ...
Ioanna Markaki, Stefanos Klironomos, Konstantinos Kostulas, Christina Sjostrand   +3 more
doaj   +1 more source

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source

Role of homocysteine in the development and progression of Parkinson’s disease

Annals of Clinical and Translational Neurology, 2020
Homocysteine is an essential intermediate product of biochemical reactions that is present in various tissues of the human body. Homocysteine may be associated with the development and progression of Parkinson’s disease.
Xiaoyan Fan, Lixia Zhang, Haijun Li, Guang Chen, Gangqiao Qi, Xueqiang Ma, Yuelei Jin   +6 more
doaj   +1 more source

Homocysteine in cerebrovascular disease: An independent risk factor for subcortical vascular encephalopathy [PDF]

, 2001
Hyperhomocysteinemia is a risk factor for obstructive large-vessel disease. Here, we studied plasma concentrations of homocysteine and vitamins in patients suffering from subcortical vascular encephalopathy (SVE), a cerebral small-vessel disease leading ...
Aufenanger, Johannes, Bertsch, Thomas, Casarin, Wendy, Fassbender, Klaus, Höly, Sabine, Kuehl, Sandra, Mielke, Orell, Muehlhauser, Frank, Ragoschke, Andreas, Walter, Silke, Zimmer, Wilma   +10 more
core   +1 more source

Proteogenomic characterization of cholangiocarcinoma

Hepatology, EarlyView., 2022
Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng, Peng Ran, Lingli Chen, Yunzhi Wang, Zixiang Yu, Ke Cai, Jinwen Feng, Zhaoyu Qin, Yanan Yin, Subei Tan, Yang Liu, Chen Xu, Guoming Shi, Yuan Ji, Jian‐Yuan Zhao, Jian Zhou, Jia Fan, Yingyong Hou, Chen Ding   +18 more
wiley   +1 more source

Plasma homocysteine levels in patients with liver cirrhosis [PDF]

Vojnosanitetski Pregled, 2013
Background/Aim. Homocysteine (2-amino-4-mercaptobutyric acid) is an amino acid that may be found in small quantities in all cells, and is quantitatively the major methionine metabolite. The most prevalent form is protein-bound homocysteine (about 80%),
Ćulafić Đorđe M., Marković Miroslav Lj., Obrenović Radmila Ž., Mijač Dragana D.   +3 more
doaj   +1 more source

Digenic Functional B12 and Folate Defect Mimicking Myelodysplasia. [PDF]

Clin Case Rep
Proposed mechanistic model of mutation‐related outcomes. ABSTRACT A digenic defect involving CUBN and MTHFR produced functional B12/folate deficiency in a patient with pancytopenia and neurological signs, mimicking myelodysplasia. Genetic and metabolic screening revealed elevated methylmalonic acid/homocysteine, with rapid remission post‐parenteral B12.
Cluzeau T, Oussalah A, Silva Rodriguez M, Naïmi M.   +3 more
europepmc   +2 more sources

Mining literature for a comprehensive pathway analysis: A case study for retrieval of homocysteine related genes for genetic and epigenetic studies

Lipids in Health and Disease, 2006
Homocysteine is an independent risk factor for cardiovascular diseases. It is also known to be associated with a variety of complex disorders. While there are a large number of independent studies implicating homocysteine in isolated pathways, the ...
Mahajan Anubha, Sundaramoorthy Elayanambi, Brahmachari Vani, Senthilkumar RD, Sharma Priyanka, Sharma Amitabh, Sengupta Shantanu   +6 more
doaj   +1 more source

Homocysteine

Comprehensive Therapy, 2002
Homocystemia is a pathological condition that represents a significant role in cardiovascular morbidity and mortality. The epidemiology, pathophysiology, and clinical diagnostics and treatment aspects are described and discussed.
Robert, Hasty, Edward N, Smolar
openaire   +4 more sources

Evidence Favoring a Positive Feedback Loop for Physiologic Auto Upregulation of hnRNP-E1 during Prolonged Folate Deficiency in Human Placental Cells [PDF]

, 2017
Background: Previously, we determined that heterogeneous nuclear ribonucleoprotein E1 (hnRNP-E1) functions as an intracellular physiologic sensor of folate deficiency.
Antony, Aśok C., Hansen, Deborah K., Jayaram, Hiremagalur N., Khan, Rehana A., Kusumanchi, Praveen, Stabler, Sally P., Tang, Ying-Sheng, Xiao, Suhong   +7 more
core   +1 more source