Results 101 to 110 of about 1,288,242 (386)
A Hierarchical Approach to Protein Molecular Evolution [PDF]
, 1999 Biological diversity has evolved despite the essentially infinite complexity of protein sequence space. We present a hierarchical approach to the efficient searching of this space and quantify the evolutionary potential of our approach with Monte Carlo ...
Crameri +30 more
core +2 more sources
Genes & Development, 2017 Yazinski et al. show that the functions of BRCA1 in homologous recombination and replication fork protection are sequentially bypassed during the acquisition of PARP inhibitor (PARPi) resistance.
Stephanie A. Yazinski +15 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli +10 more
wiley +1 more source
Kirby calculus for null-homologous framed links in 3-manifolds [PDF]
, 2017 A theorem of Kirby gives a necessary and sufficient condition for two framed links in S^3 to yield orientation-preserving diffeomorphic results of surgery. Kirby's theorem is an important method for constructing invariants of 3-manifolds.
Habiro, Kazuo, Widmer, Tamara
core +1 more source
LOOP HOMOLOGY AS FIBREWISE HOMOLOGY [PDF]
Proceedings of the Edinburgh Mathematical Society, 2008 AbstractThe loop homology ring of an oriented closed manifold, defined by Chas and Sullivan, is interpreted as a fibrewise homology Pontrjagin ring. The basic structure, particularly the commutativity of the loop multiplication and the homotopy invariance, is explained from the viewpoint of the fibrewise theory, and the definition is extended to ...
openaire +2 more sources
Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer
Molecular Oncology, EarlyView.mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia +17 more
wiley +1 more source
Cross Immunity of a Sonicated Trivalent Avian Colibacillosis Vaccine to Pathogenic Escherichia coli O26 and O78 Strains in Broiler Chickens [PDF]
The Iranian Journal of Veterinary Science and TechnologyColibacillosis outbreaks are a global issue affecting the poultry industry. There is no cross-immunity among the strains of APEC. If a vaccine induces cross-immunity, it will play a key role in preventing colibacillosis.
Sima Alempour Rajabi, Zolfaghar Rajabi
doaj +1 more source
Homologous Pairing between Long DNA Double Helices
, 2016 Molecular recognition between two double stranded (ds) DNA with homologous sequences may not seem compatible with the B-DNA structure because the sequence information is hidden when it is used for joining the two strands.
Mazur, Alexey K.
core +1 more source
An Evolutionary Interpretation of Teleostean Forebrain Anatomy [PDF]
, 2009 During the past few years, our investigations of the forebrain in the zebrafish (a teleost fish) have shown that its molecular anatomy and expression patterns of genes involved in the regulation of neuronal transmitter phenotypes, such as gamma ...
Mueller, Thomas, Wullimann, Mario F.
core +1 more source
Molecular Oncology, EarlyView.MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin +14 more
wiley +1 more source