Results 101 to 110 of about 1,318,508 (390)
Nature Biotechnology, 2015 Methods to introduce targeted double-strand breaks (DSBs) into DNA enable precise genome editing by increasing the rate at which externally supplied DNA fragments are incorporated into the genome through homologous recombination.
T. Maruyama +5 more
semanticscholar +1 more source
Dissipationless Collapse of Spherical Protogalaxies and the Fundamental Plane [PDF]
, 2001 Following on from the numerical work of Capelato, de Carvalho & Carlberg (1995, 1997), where dissipationless merger simulations were shown to reproduce the "Fundamental Plane" (FP) of elliptical galaxies, we investigate whether the end products of pure ...
A. L. B. Ribeiro +32 more
core +4 more sources
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Shanghai yufang yixueObjectiveTo determine the drug sensitivity and molecular typing characteristics of Klebsiella pneumoniae isolated from meat and diarrhea samples in a local area.MethodsSeventy-one strains of K.pneumoniae were isolated from 118 meat food （chicken and pork）
QUE Fengxia +5 more
doaj +1 more source
Veterinární Medicína, 2016 The effect of adding high or low protein content homologous seminal plasma to boar spermatozoa on the progressive motility of the spermatozoa after storage for three days, and at a 1 : 4 dilution ratio was investigated. A total of 32 ejaculates collected
J. Apic +6 more
doaj +1 more source
Mediterranean Fin Whales (Balaenoptera physalus) Threatened by Dolphin MorbilliVirus [PDF]
, 2015 During 2011-2013, dolphin morbillivirus was molecularly identified in 4 stranded fin whales from the Mediterranean Sea. Nucleoprotein, phosphoprotein, and hemagglutinin gene sequences of the identified strain were highly homologous with those of a ...
BEFFAGNA, GIORGIA +11 more
core +3 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Exploiting Homology Information in Nontemplate Based Prediction of Protein Structures [PDF]
, 2015 In this paper we describe a novel strategy for exploring the conformational space of proteins and show that this leads to better models for proteins the structure of which is not amenable to template based methods. Our strategy is based on the assumption
Alfredo Iacoangeli +3 more
core +2 more sources
Homological descent for motivic homology theories [PDF]
Homology, Homotopy and Applications, 2014 We show that motivic homology, motivic Borel-Moore homology and higher Chow groups satisfy homological descent for hyperenvelopes, and l-hyperenvelopes after inverting l.
openaire +3 more sources
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source