Results 111 to 120 of about 1,084,291 (336)
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Following multi-dimensional Type Ia supernova explosion models to homologous expansion
, 2004 The last years have witnessed a rapid development of three-dimensional models of Type Ia supernova explosions. Consequently, the next step is to evaluate these models under variation of the initial parameters and to compare them with observations.
Buchler +32 more
core +2 more sources
Discrete Mathematics, 1971 AbstractWith each bounded lattice L is associated a simplicial complex KL. If X is a cross-cut of L, then a simplicial complex KX is defined. It is shown that the geometric realizations of KX and KL are homotopy equivalent.
openaire +3 more sources
Molecular Oncology, EarlyView.Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh +5 more
wiley +1 more source
One parameter Viscosity-Temperature Correlation for Homologous n-Alkanes Series from CH4 to C20H42
Journal of Engineering and Sustainable Development, 2012 The main aim of this paper is to establish a correlation for prediction the dynamic viscosity of homologous n-alkanes from CH4 to C20H42 at isobaric condition within a given temperature range.
Harith Hasoon Jasim
doaj
Cross Immunity of a Sonicated Trivalent Avian Colibacillosis Vaccine to Pathogenic Escherichia coli O26 and O78 Strains in Broiler Chickens [PDF]
The Iranian Journal of Veterinary Science and TechnologyColibacillosis outbreaks are a global issue affecting the poultry industry. There is no cross-immunity among the strains of APEC. If a vaccine induces cross-immunity, it will play a key role in preventing colibacillosis.
Sima Alempour Rajabi, Zolfaghar Rajabi
doaj +1 more source
Molecular Oncology, EarlyView.RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha +10 more
wiley +1 more source
The Challenge of Defining Laterality in Horses: Is It Laterality or Just Asymmetry?
AnimalsThe defining characteristic of laterality is the dominance of one side of the brain controlling specific functions of paired organs or on one side of the body.
Kevin K. Haussler +4 more
doaj +1 more source
A Homologous Series of Cobalt, Rhodium, and Iridium Metalloradicals [PDF]
, 2012 We herein present a series of d7 trimethylphosphine complexes of group 9 metals that are chelated by the tripodal tetradentate tris(phosphino)silyl ligand [SiP^(iPr)_3]H ([SiP^(iPr)_3] = (2_(-i)Pr_2PC_6H_4)_3Si^–).
Peters, Jonas C., Takaoka, Ayumi
core +1 more source
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source