Results 111 to 120 of about 1,047,361 (285)

One parameter Viscosity-Temperature Correlation for Homologous n-Alkanes Series from CH4 to C20H42

Journal of Engineering and Sustainable Development, 2012
The main aim of this paper is to establish a correlation for prediction the dynamic viscosity of homologous n-alkanes from CH4 to C20H42 at isobaric condition within a given temperature range.
Harith Hasoon Jasim
doaj  

Homologous non-isotopic symplectic tori in a K3-surface

, 2003
For each member of an infinite family of homology classes in the K3-surface E(2), we construct infinitely many non-isotopic symplectic tori representing this homology class. This family has an infinite subset of primitive classes.
B. DOUG PARK, Fintushel R., Thurston W. P., TOLGA ETGÜ   +3 more
core   +3 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

The Challenge of Defining Laterality in Horses: Is It Laterality or Just Asymmetry?

Animals
The defining characteristic of laterality is the dominance of one side of the brain controlling specific functions of paired organs or on one side of the body.
Kevin K. Haussler, Sarah S. le Jeune, Russell MacKechnie-Guire, Selma N. Latif, Hilary M. Clayton   +4 more
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Drug resistance and molecular typing characteristics of Klebsiella pneumoniae in meat food and diarrhea samples in a local area

Shanghai yufang yixue
ObjectiveTo determine the drug sensitivity and molecular typing characteristics of Klebsiella pneumoniae isolated from meat and diarrhea samples in a local area.MethodsSeventy-one strains of K.pneumoniae were isolated from 118 meat food （chicken and pork）
QUE Fengxia, YUAN Jiachun, HAN Dongfang, LIU Chunfu, SONG Canlei, YE Yulong   +5 more
doaj   +1 more source

LOOP HOMOLOGY AS FIBREWISE HOMOLOGY [PDF]

Proceedings of the Edinburgh Mathematical Society, 2008
AbstractThe loop homology ring of an oriented closed manifold, defined by Chas and Sullivan, is interpreted as a fibrewise homology Pontrjagin ring. The basic structure, particularly the commutativity of the loop multiplication and the homotopy invariance, is explained from the viewpoint of the fibrewise theory, and the definition is extended to ...
openaire   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source