Results 111 to 120 of about 1,318,508 (390)

Structural basis of homologous recombination

Cellular and Molecular Life Sciences, 2019
Homologous recombination (HR) is a pathway to faithfully repair DNA double-strand breaks (DSBs). At the core of this pathway is a DNA recombinase, which, as a nucleoprotein filament on ssDNA, pairs with homologous DNA as a template to repair the damaged ...
Yueru Sun, T. McCorvie, L. Yates, Xiaodong Zhang   +3 more
semanticscholar   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Dynamic Changes of Active Components and Volatile Organic Compounds in Rosa roxburghii Fruit during the Process of Maturity

Foods
Rosa roxburghii (R. roxburghii), native to the southwest provinces of China, is a fruit crop of important economic value in Guizhou Province. However, the changes in fruit quality and flavor during R. roxburghii fruit ripening have remained unknown. Here,
Su Xu, Junyi Deng, Siyao Wu, Qiang Fei, Dong Lin, Haijiang Chen, Guangcan Tao, Lingshuai Meng, Yan Hu, Fengwei Ma   +9 more
doaj   +1 more source

A New Mouse Liver-specific Gene, Encoding a Protein Homologous to Human Antimicrobial Peptide Hepcidin, Is Overexpressed during Iron Overload*

Journal of Biological Chemistry, 2001
Considering that the development of hepatic lesions related to iron overload diseases might be a result of abnormally expressed hepatic genes, we searched for new genes up-regulated under the condition of iron excess.
C. Pigeon, G. Ilyin, Brice Courselaud, P. Leroyer, B. Turlin, P. Brissot, O. Loréal   +6 more
semanticscholar   +1 more source

Modular Homology Characters [PDF]

Proceedings of the National Academy of Sciences, 1932
This paper gives definitions and some simple properties of homology characters modulo any integer preceded by a discussion of matrices modulo any integer.
openaire   +3 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Astragalin Attenuates Dextran Sulfate Sodium (DSS)-Induced Acute Experimental Colitis by Alleviating Gut Microbiota Dysbiosis and Inhibiting NF-κB Activation in Mice

Frontiers in Immunology, 2020
With the ulcerative colitis (UC) incidence increasing worldwide, it is of great importance to prevent and treat UC. However, efficient treatment options for UC are relatively limited.
Lei Peng, Lei Peng, Lei Peng, Xiaoyu Gao, Xiaoyu Gao, Xiaoyu Gao, Long Nie, Jing Xie, Jing Xie, Jing Xie, Tianyi Dai, Tianyi Dai, Tianyi Dai, Chongying Shi, Liang Tao, Liang Tao, Liang Tao, Yan Wang, Yan Wang, Yang Tian, Yang Tian, Yang Tian, Jun Sheng, Jun Sheng   +23 more
doaj   +1 more source

Homologous Jet-Driven Coronal Mass Ejections From Solar Active Region 12192

, 2016
We report observations of homologous coronal jets and their coronal mass ejections (CMEs) observed by instruments onboard the Solar Dynamics Observatory (SDO) and Solar and Heliospheric Observatory (SOHO) spacecraft. The homologous jets originated from a
Moore, Ronald L., Panesar, Navdeep K., Sterling, Alphonse C.   +2 more
core   +1 more source

Targeted mutagenesis of the Sap47 gene of Drosophila: Flies lacking the synapse associated protein of 47 kDa are viable and fertile [PDF]

, 2004
BACKGROUND: Conserved proteins preferentially expressed in synaptic terminals of the nervous system are likely to play a significant role in brain function.
Becker, Sonja, Brunner, Marion, Buchner, Erich, Funk, Natalja, Huber, Saskia   +4 more
core   +3 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source