Results 1 to 10 of about 1,263,590 (216)

FIGNL1 Inhibits Non-homologous Chromosome Association and Crossover Formation [PDF]

Frontiers in Plant Science, 2022
Meiotic crossovers (COs) not only generate genetic diversity but also ensure the accuracy of homologous chromosome segregation. Here, we identified FIGNL1 as a new inhibitor for extra crossover formation in rice.
Shuying Yang, Shuying Yang, Shuying Yang, Chao Zhang, Yiwei Cao, Yiwei Cao, Guijie Du, Ding Tang, Yafei Li, Yi Shen, Hengxiu Yu, Zhukuan Cheng, Zhukuan Cheng, Zhukuan Cheng   +13 more
doaj   +3 more sources

CRISPR-induced double-strand breaks trigger recombination between homologous chromosome arms [PDF]

Life Science Alliance, 2019
CRISPR–Cas9 enables recombination between homologous chromosome arms at predefined sites and also underscores the need for caution when applying CRISPR technologies in translational medicine.
Erich Brunner, Ryohei Yagi, Marc Debrunner, Dezirae Beck-Schneider, Alexa Burger, Eliane Escher, Christian Mosimann, George Hausmann, Konrad Basler   +8 more
doaj   +3 more sources

Homologous chromosome pairing starts at the ends. [PDF]

Plant Physiol
De Jaeger-Braet J.
europepmc   +4 more sources

Cas9/Nickase-induced allelic conversion by homologous chromosome-templated repair in Drosophila somatic cells. [PDF]

Sci Adv, 2022
Repair of double-strand breaks (DSBs) in somatic cells is primarily accomplished by error-prone nonhomologous end joining and less frequently by precise homology-directed repair preferentially using the sister chromatid as a template.
Roy S, Juste SS, Sneider M, Auradkar A, Klanseck C, Li Z, Julio AHF, Lopez del Amo V, Bier E, Guichard A.   +9 more
europepmc   +2 more sources

The Essential Function of SETDB1 in Homologous Chromosome Pairing and Synapsis during Meiosis. [PDF]

Cell Rep, 2021
SETDB1 is a histone-lysine N-methyltransferase critical for germline development. However, its function in early meiotic prophase I remains unknown. Here, we report that Setdb1 null spermatocytes display aberrant centromere clustering during leptotene ...
Cheng EC, Hsieh CL, Liu N, Wang J, Zhong M, Chen T, Li E, Lin H.   +7 more
europepmc   +2 more sources

Characterization of Button Loci that Promote Homologous Chromosome Pairing and Cell-Type-Specific Interchromosomal Gene Regulation. [PDF]

Dev Cell, 2019
Homologous chromosomes colocalize to regulate gene expression in processes including genomic imprinting, X-inactivation, and transvection. In Drosophila, homologous chromosomes pair throughout development, promoting transvection.
Viets K, Sauria MEG, Chernoff C, Rodriguez Viales R, Echterling M, Anderson C, Tran S, Dove A, Goyal R, Voortman L, Gordus A, Furlong EEM, Taylor J, Johnston RJ.   +13 more
europepmc   +2 more sources

PAR-TERRA directs homologous sex chromosome pairing [PDF]

Nature Structural & Molecular Biology, 2017
In mammals, homologous chromosomes rarely pair outside meiosis. One exception is the X chromosome, which transiently pairs during X-chromosome inactivation (XCI). How two chromosomes find each other in 3D space is not known.
H. Chu, John E. Froberg, Barry A. Kesner, H. Oh, Fei Ji, R. Sadreyev, Stefan F. Pinter, Jeannie T. Lee   +7 more
semanticscholar   +4 more sources

Meiotic cohesin-based chromosome structure is essential for homologous chromosome pairing in Schizosaccharomyces pombe. [PDF]

Chromosoma, 2016
Chromosome structure is dramatically altered upon entering meiosis to establish chromosomal architectures necessary for the successful progression of meiosis-specific events. An early meiotic event involves the replacement of the non-SMC mitotic cohesins
Ding DQ, Matsuda A, Okamasa K, Nagahama Y, Haraguchi T, Hiraoka Y.   +5 more
europepmc   +2 more sources

Chromosome architecture and homologous recombination in meiosis

Frontiers in Cell and Developmental Biology, 2023
Meiocytes organize higher-order chromosome structures comprising arrays of chromatin loops organized at their bases by linear axes. As meiotic prophase progresses, the axes of homologous chromosomes align and synapse along their lengths to form ladder ...
Masaru Ito, Akira Shinohara
doaj   +3 more sources

Modeling homologous chromosome recognition via nonspecific interactions. [PDF]

Proc Natl Acad Sci U S A
In many organisms, most notably Drosophila , homologous chromosomes associate in somatic cells, a phenomenon known as somatic pairing, which takes place without double strand breaks or strand invasion, thus requiring some other mechanism for homologs to recognize each other.
Marshall WF, Fung JC.
europepmc   +5 more sources