FIGNL1 Inhibits Non-homologous Chromosome Association and Crossover Formation [PDF]
Frontiers in Plant Science, 2022 Meiotic crossovers (COs) not only generate genetic diversity but also ensure the accuracy of homologous chromosome segregation. Here, we identified FIGNL1 as a new inhibitor for extra crossover formation in rice.
Shuying Yang +13 more
doaj +3 more sources
Cas9/Nickase-induced allelic conversion by homologous chromosome-templated repair in Drosophila somatic cells. [PDF]
Sci Adv, 2022 Repair of double-strand breaks (DSBs) in somatic cells is primarily accomplished by error-prone nonhomologous end joining and less frequently by precise homology-directed repair preferentially using the sister chromatid as a template.
Roy S +9 more
europepmc +2 more sources
CRISPR-induced double-strand breaks trigger recombination between homologous chromosome arms. [PDF]
Life Sci Alliance, 2019 CRISPR–Cas9 enables recombination between homologous chromosome arms at predefined sites and also underscores the need for caution when applying CRISPR technologies in translational medicine.
Brunner E +8 more
europepmc +2 more sources
Chromosome architecture and homologous recombination in meiosis
Frontiers in Cell and Developmental Biology, 2023 Meiocytes organize higher-order chromosome structures comprising arrays of chromatin loops organized at their bases by linear axes. As meiotic prophase progresses, the axes of homologous chromosomes align and synapse along their lengths to form ladder ...
Masaru Ito, Akira Shinohara
doaj +3 more sources
Meiotic cohesin-based chromosome structure is essential for homologous chromosome pairing in Schizosaccharomyces pombe. [PDF]
Chromosoma, 2016 Chromosome structure is dramatically altered upon entering meiosis to establish chromosomal architectures necessary for the successful progression of meiosis-specific events. An early meiotic event involves the replacement of the non-SMC mitotic cohesins
Ding DQ +5 more
europepmc +2 more sources
Meiotic telomeres: a matchmaker for homologous chromosomes [PDF]
Genes to Cells, 1998 Telomeres, with their special structures and special schemes of synthesis, are essential for protecting the ends of eukaryotic linear chromosomes during cell proliferation. In addition to this basic function, the meiosis‐specific functions of telomeres have long been inferred from the cytological observations of characteristic chromosome configurations
Yasushi Hiraoka
openalex +4 more sources
Control of homologous chromosome division in the mammalian oocyte. [PDF]
Molecular Human Reproduction, 2009 Homologous chromosomes are segregated during the first meiotic division (meiosis I). Unfortunately, human oocytes are particularly susceptible to mis-segregation errors, so generating aneuploid, often non-viable, embryos.
J. Holt, K. Jones
semanticscholar +4 more sources
Recruitment and rejoining of remote double-strand DNA breaks for enhanced and precise chromosome editing [PDF]
Genome BiologyChromosomal rearrangements, such as translocations, deletions, and inversions, underlie numerous genetic diseases and cancers, yet precise engineering of these rearrangements remains challenging.
Mingyao Wang +6 more
doaj +2 more sources
Zoo-FISH in the European mole (Talpa europaea) detects all ancestral Boreo-Eutherian human homologous chromosome associations [PDF]
Cytogenetic and Genome Research, 2006 Zoo-FISH with human whole-chromosome paint probes delineated syntenic association of human homologous chromosome segments 3-21, 14-15, 16-19, 4-8, 7-16 and 12-22 (twice) in the European mole (Talpa europaea, Talpidae, Eulipotyphla, Mammalia).
Jimenez R +5 more
core +2 more sources
The onset of homologous chromosome pairing during Drosophila melanogaster embryogenesis. [PDF]
Journal of Cell Biology, 1993 We have determined the position within the nucleus of homologous sites of the histone gene cluster in Drosophila melanogaster using in situ hybridization and high-resolution, three-dimensional wide field fluorescence microscopy.
Agard, DA +5 more
core +2 more sources