FIGNL1 Inhibits Non-homologous Chromosome Association and Crossover Formation [PDF]
Frontiers in Plant Science, 2022 Meiotic crossovers (COs) not only generate genetic diversity but also ensure the accuracy of homologous chromosome segregation. Here, we identified FIGNL1 as a new inhibitor for extra crossover formation in rice.
Shuying Yang +13 more
doaj +3 more sources
Cas9/Nickase-induced allelic conversion by homologous chromosome-templated repair in Drosophila somatic cells. [PDF]
Sci Adv, 2022 Repair of double-strand breaks (DSBs) in somatic cells is primarily accomplished by error-prone nonhomologous end joining and less frequently by precise homology-directed repair preferentially using the sister chromatid as a template.
Roy S +9 more
europepmc +2 more sources
CRISPR-induced double-strand breaks trigger recombination between homologous chromosome arms. [PDF]
Life Sci Alliance, 2019 CRISPR–Cas9 enables recombination between homologous chromosome arms at predefined sites and also underscores the need for caution when applying CRISPR technologies in translational medicine.
Brunner E +8 more
europepmc +2 more sources
Chromosome architecture and homologous recombination in meiosis
Frontiers in Cell and Developmental Biology, 2023 Meiocytes organize higher-order chromosome structures comprising arrays of chromatin loops organized at their bases by linear axes. As meiotic prophase progresses, the axes of homologous chromosomes align and synapse along their lengths to form ladder ...
Masaru Ito, Akira Shinohara
doaj +3 more sources
Meiotic cohesin-based chromosome structure is essential for homologous chromosome pairing in Schizosaccharomyces pombe. [PDF]
Chromosoma, 2016 Chromosome structure is dramatically altered upon entering meiosis to establish chromosomal architectures necessary for the successful progression of meiosis-specific events. An early meiotic event involves the replacement of the non-SMC mitotic cohesins
Ding DQ +5 more
europepmc +2 more sources
Control of homologous chromosome division in the mammalian oocyte. [PDF]
Molecular Human Reproduction, 2009 Homologous chromosomes are segregated during the first meiotic division (meiosis I). Unfortunately, human oocytes are particularly susceptible to mis-segregation errors, so generating aneuploid, often non-viable, embryos. Here we review the cell biology of meiosis I and how homolog disjunction is regulated for mammalian oocytes.
J. Holt, K. Jones
semanticscholar +4 more sources
BMC Plant Biology, 2019 Background Clubroot, caused by Plasmodiophora brassicae Woronin, is a very important disease of Brassica species. Management of clubroot relies heavily on genetic resistance.
Adrian Chang +7 more
doaj +2 more sources
Recruitment and rejoining of remote double-strand DNA breaks for enhanced and precise chromosome editing [PDF]
Genome BiologyChromosomal rearrangements, such as translocations, deletions, and inversions, underlie numerous genetic diseases and cancers, yet precise engineering of these rearrangements remains challenging.
Mingyao Wang +6 more
doaj +2 more sources
Homologous chromosome pairing in Schizosaccharomyces pombe
Yeast, 2006 AbstractHomologous chromosome pairing is a central feature of meiosis I, contributing to the correct segregation of chromosomes during meiosis. The fission yeast, Schizosaccharomyces pombe, has been widely used to study meiotic chromosome dynamics, partly because studies in this yeast are simplified due to the lack of post‐pairing synaptic structures ...
J. Wells, D. Pryce, R. J. McFarlane
semanticscholar +4 more sources
Homologous chromosome pairing starts at the ends. [PDF]
Plant PhysiolDe Jaeger-Braet J.
europepmc +3 more sources