Results 41 to 50 of about 1,025,592 (331)

Chromosomally-retained RNA mediates homologous pairing [PDF]

Nucleus, 2012
Pairing and recombination of homologous chromosomes are essential for ensuring correct segregation of chromosomes in meiosis. In S. pombe, chromosomes are first bundled at the telomeres (forming a telomere bouquet) and then aligned by oscillatory movement of the elongated "horsetail" nucleus.
Da-Qiao Ding, Tokuko Haraguchi, Yasushi Hiraoka   +2 more
openaire   +3 more sources

The courtship choreography of homologous chromosomes: timing and mechanisms of DSB-independent pairing

Frontiers in Cell and Developmental Biology, 2023
Meiosis involves deep changes in the spatial organisation and interactions of chromosomes enabling the two primary functions of this process: increasing genetic diversity and reducing ploidy level.
Mireia Solé, Álvaro Pascual, Ester Anton, Joan Blanco, Zaida Sarrate   +4 more
doaj   +1 more source

Mouse HFM1/Mer3 is required for crossover formation and complete synapsis of homologous chromosomes during meiosis. [PDF]

PLoS Genetics, 2013
Faithful chromosome segregation during meiosis requires that homologous chromosomes associate and recombine. Chiasmata, the cytological manifestation of recombination, provide the physical link that holds the homologs together as a pair, facilitating ...
Michel F Guiraldelli, Craig Eyster, Joseph L Wilkerson, Michael E Dresser, Roberto J Pezza   +4 more
doaj   +1 more source

PAR-TERRA directs homologous sex chromosome pairing

Nature Structural &Molecular Biology, 2017
In mammals, homologous chromosomes rarely pair outside meiosis. One exception is the X chromosome, which transiently pairs during X-chromosome inactivation (XCI). How two chromosomes find each other in 3D space is not known.
H. Chu, John E. Froberg, Barry A. Kesner, H. Oh, Fei Ji, R. Sadreyev, Stefan F. Pinter, Jeannie T. Lee   +7 more
semanticscholar   +1 more source

Specific deletion of Cdc42 does not affect meiotic spindle organization/migration and homologous chromosome segregation but disrupts polarity establishment and cytokinesis in mouse oocytes

Molecular Biology of the Cell, 2013
Oocyte-specific deletion of Cdc42 has little effect on meiotic spindle organization and migration to the cortex but inhibits polar body emission, although homologous chromosome segregation occurs.
Zhenbo Wang, Zong-Zhe Jiang, Qing-Hua Zhang, Meng-Wen Hu, Lin Huang, Xiang‐Hong Ou, Lei Guo, Yingchun Ouyang, Yi Hou, C. Brakebusch, H. Schatten, Qing-Yuan Sun   +11 more
semanticscholar   +1 more source

Homologous chromosome pairing in Schizosaccharomyces pombe

Yeast, 2006
AbstractHomologous chromosome pairing is a central feature of meiosis I, contributing to the correct segregation of chromosomes during meiosis. The fission yeast, Schizosaccharomyces pombe, has been widely used to study meiotic chromosome dynamics, partly because studies in this yeast are simplified due to the lack of post‐pairing synaptic structures ...
J. Wells, D. Pryce, R. J. McFarlane
semanticscholar   +4 more sources

Distance between homologous chromosomes results from chromosome positioning constraints [PDF]

Journal of Cell Science, 2010
The organization of chromosomes is important for various biological processes and is involved in the formation of rearrangements often observed in cancer. In mammals, chromosomes are organized in territories that are radially positioned in the nucleus. However, it remains unclear whether chromosomes are organized relative to each other.
Heride, Claire, Ricoul, Michelle, Kiêu, Kiên, von Hase, Johann, Guillemot, Vincent, Cremer, Christoph, Dubrana, Karine, Sabatier, Laure   +7 more
openaire   +5 more sources

Agent-based modeling of nuclear chromosome ensembles identifies determinants of homolog pairing during meiosis.

PLoS Computational Biology
During meiosis, pairing of homologous chromosomes (homologs) ensures the formation of haploid gametes from diploid precursor cells, a prerequisite for sexual reproduction.
Ariana Chriss, G Valentin Börner, Shawn D Ryan   +2 more
doaj   +1 more source

Extensive DNA end processing by exo1 and sgs1 inhibits break-induced replication.

PLoS Genetics, 2010
Homology-dependent repair of DNA double-strand breaks (DSBs) by gene conversion involves short tracts of DNA synthesis and limited loss of heterozygosity (LOH).
Vanessa A Marrero, Lorraine S Symington
doaj   +1 more source

The Attraction between Homologous Chromosomes [PDF]

Nature, 1925
IT has been shown that the chromosomes of Datura (American Naturalist, vol. 56, pp. 339–346, 1922), Hyacinthus (Genetics, vol. 10, pp. 59–71, 1925) and Uvularia (Journal of Genetics, in press), for example, are combined side by side, and end to end, at the reduction division.
openaire   +2 more sources