Results 101 to 110 of about 2,294,281 (319)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Modeling meiotic chromosomes indicates a size dependent contribution of telomere clustering and chromosome rigidity to homologue juxtaposition.

PLoS Computational Biology, 2012
Meiosis is the cell division that halves the genetic component of diploid cells to form gametes or spores. To achieve this, meiotic cells undergo a radical spatial reorganisation of chromosomes.
Christopher A Penfold, Paul E Brown, Neil D Lawrence, Alastair S H Goldman   +3 more
doaj   +1 more source

A separation-of-function ZIP4 wheat mutant allows crossover between related chromosomes and is meiotically stable

Scientific Reports, 2021
Many species, including most flowering plants, are polyploid, possessing multiple genomes. During polyploidisation, fertility is preserved via the evolution of mechanisms to control the behaviour of these multiple genomes during meiosis.
Azahara C. Martín, Abdul Kader Alabdullah, Graham Moore   +2 more
doaj   +1 more source

RNA secondary structure prediction from multi-aligned sequences [PDF]

, 2013
It has been well accepted that the RNA secondary structures of most functional non-coding RNAs (ncRNAs) are closely related to their functions and are conserved during evolution.
A Balik, A Pauli, A Wilm, A Wilm, AC Penn, AR Gruber, AS Richter, B Knudsen, B Knudsen, C Witwer, CB Do, D Jager, D Sankoff, D Wei, DH Mathews, DH Mathews, E Bindewald, E Freyhult, E Rivas, EJ Meer, H Kiryu, H Yonemoto, IA Qureshi, IL Hofacker, IL Hofacker, IV Novikova, J Ruan, J Spirollari, JG Underwood, JM Watts, JR Proctor, JS McCaskill, JT Low, K Katoh, K Sato, K Sato, K Sato, KM Wong, LE Carvalho, M Andronescu, M Andronescu, M Esteller, M Hamada, M Hamada, M Hamada, M Hamada, M Hamada, M Hamada, M Hamada, M Hamada, M Kertesz, ME Nebel, MS Andronescu, P Ge, PP Gardner, PS Pang, R Luck, RD Dowell, RJ Klein, S Washietl, S Washietl, S Washietl, S Washietl, SE Seemann, SE Seemann, SH Bernhart, SM Sahraeian, SW Burge, T Puton, T Xia, Y Kato, Z Sukosd   +71 more
core   +1 more source

Human PSF concentrates DNA and stimulates duplex capture in DMC1-mediated homologous pairing

Nucleic Acids Research, 2011
PSF is considered to have multiple functions in RNA processing, transcription and DNA repair by mitotic recombination. In the present study, we found that PSF is produced in spermatogonia, spermatocytes and spermatids, suggesting that PSF may also ...
Yuichi Morozumi, Ryohei Ino, Motoki Takaku, Mihoko Hosokawa, Shinichiro Chuma, H. Kurumizaka   +5 more
semanticscholar   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Probing Rad51-DNA interactions by changing DNA twist [PDF]

, 2017
In eukaryotes, Rad51 protein is responsible for the recombinational repair of double-strand DNA breaks. Rad51 monomers cooperatively assemble on exonuclease-processed broken ends forming helical nucleo-protein filaments that can pair with homologous ...
Atwell, Scott, Cappello, Giovanni, Disseau, Ludovic, Renodon-Cornière, Axelle, Stasiak, Alicja Z., Stasiak, Andrzej, Takahashi, Masayuki, Viovy, Jean-Louis   +7 more
core  

Homologous Pairing Promoted by Ustilago RecI Protein

Cold Spring Harbor Symposia on Quantitative Biology, 1984
Progress in understanding the basis of recombination has lagged behind the related and overlapping areas of replication and repair for a number of reasons. For instance, the most favorable organisms for genetic analysis of recombination have not coincided with those most suitable for molecular studies. E.
E, Kmiec, P, Kroeger, R, Holliday, W, Holloman   +3 more
openaire   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

A new meiosis-specific cohesin complex implicated in the cohesin code for homologous pairing

EMBO Reports, 2011
We identify a new mammalian cohesin subunit, RAD21‐like protein (RAD21L), with sequence similarity to RAD21 and REC8. RAD21L localizes along axial elements in early meiotic prophase, in a manner that is spatiotemporally different to either REC8 or RAD21.
K. Ishiguro, Jihye Kim, Sally Fujiyama-Nakamura, S. Kato, Yoshinori Watanabe   +4 more
semanticscholar   +1 more source