Results 81 to 90 of about 2,294,281 (319)
The TERB1 MYB domain suppresses telomere erosion in meiotic prophase I
Cell Reports, 2022 Summary: The meiosis-specific telomere-binding protein TERB1 anchors telomeres to the nuclear envelope and drives chromosome movements for the pairing of homologous chromosomes.
Kexin Zhang +6 more
doaj +1 more source
Mitotic antipairing of homologous and sex chromosomes via spatial restriction of two haploid sets. [PDF]
, 2018 Pairing homologous chromosomes is required for recombination. However, in nonmeiotic stages it can lead to detrimental consequences, such as allelic misregulation and genome instability, and is rare in human somatic cells.
Hua, Lisa L, Mikawa, Takashi
core +1 more source
PLoS Genetics, 2012 During meiosis, chromosomes align with their homologous pairing partners and stabilize this alignment through assembly of the synaptonemal complex (SC). Since the SC assembles cooperatively yet is indifferent to homology, pairing and SC assembly must be ...
Weibin Zhang +9 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
PLoS Genetics, 2021 Reduction of genome ploidy from diploid to haploid necessitates stable pairing of homologous chromosomes into bivalents before the start of the first meiotic division.
Luisa Vernizzi, Christian F Lehner
doaj +1 more source
Dynein-dependent processive chromosome motions promote homologous pairing in C. elegans meiosis
Journal of Cell Biology, 2012 High-resolution time-lapse imaging of meiosis in C. elegans reveals stage-specific, dynein-driven chromosome motion that accelerates homologue pairing and triggers synapsis.
David J Wynne +3 more
semanticscholar +1 more source
On the relative homology of q-Runge pairs
Arkiv för Matematik, 2000 Using \(q\)-convex functions of \textit{A. Andreotti} and \textit{H. Grauert} [Bull. Soc. Math. Fr. 90, 193--259 (1962; Zbl 0106.05501)] we say that a pair \((X,Y)\), where \(X\) is a complex space and \(Y\) an open subset of \(X\), is \(q\)-Runge if for every compact set \(K\subset Y\) there exists a \(q\)-convex function \(\phi : X\to \mathbb R ...
openaire +3 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Quantitative dynamics of telomere bouquet formation.
PLoS Computational Biology, 2012 The mechanism by which homologous chromosomes pair during meiosis, as a prelude to recombination, has long been mysterious. At meiosis, the telomeres in many organisms attach to the nuclear envelope and move together to form the telomere bouquet, perhaps
David M Richards +5 more
doaj +1 more source
Germline progenitors escape the widespread phenomenon of homolog pairing during Drosophila development. [PDF]
PLoS Genetics, 2013 Homolog pairing, which plays a critical role in meiosis, poses a potential risk if it occurs in inappropriate tissues or between nonallelic sites, as it can lead to changes in gene expression, chromosome entanglements, and loss-of-heterozygosity due to ...
Eric F Joyce +3 more
doaj +1 more source