Which one is the real matchmaker for the pair?
Asian Journal of Andrology, 2014 A fundamental question for meiosis is how homologous chromosomes (homologs) find each other and pair together to ensure homologous recombination and segregation.
Chunsheng Han
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Theory of phase segregation in DNA assemblies containing two different base pair sequence types [PDF]
, 2016 Spontaneous pairing of homologous DNA sequences – a challenging subject in molecular biophysics, often referred to as ‘homology recognition’ – ha s been observed in vitro for several DNA system s a . One of th e se experiments involved liquid crystalline
Kornyshev, AA, Lee, DJ, Wynveen, A
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Promotion of RAD51-mediated homologous DNA pairing by BRCA1-BARD1
Nature, 2017 The tumour suppressor complex BRCA1–BARD1 functions in the repair of DNA double-stranded breaks by homologous recombination. During this process, BRCA1–BARD1 facilitates the nucleolytic resection of DNA ends to generate a single-stranded template for the
Weixing Zhao +19 more
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A Role for RNA Synthesis in Homologous Pairing Events [PDF]
Molecular and Cellular Biology, 1994 The relationship between RNA synthesis and homologous pairing in vitro, catalyzed by RecA protein, was examined by using an established strand transfer assay system. When a short DNA duplex is mixed with single-stranded circles, RecA protein promotes the transfer of the minus strand of the duplex onto the complementary region of the plus-strand circle,
H, Kotani, E B, Kmiec
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Chromosome painting reveals asynaptic full alignment of homologs and HIM-8-dependent remodeling of X chromosome territories during Caenorhabditis elegans meiosis. [PDF]
PLoS Genetics, 2011 During early meiotic prophase, a nucleus-wide reorganization leads to sorting of chromosomes into homologous pairs and to establishing associations between homologous chromosomes along their entire lengths.
Kentaro Nabeshima +2 more
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PAR-TERRA directs homologous sex chromosome pairing
Nature Structural &Molecular Biology, 2017 In mammals, homologous chromosomes rarely pair outside meiosis. One exception is the X chromosome, which transiently pairs during X-chromosome inactivation (XCI). How two chromosomes find each other in 3D space is not known.
H. Chu +7 more
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Developing single-molecule TPM experiments for direct observation of successful RecA-mediated strand exchange reaction. [PDF]
PLoS ONE, 2011 RecA recombinases play a central role in homologous recombination. Once assembled on single-stranded (ss) DNA, RecA nucleoprotein filaments mediate the pairing of homologous DNA sequences and strand exchange processes.
Hsiu-Fang Fan +2 more
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Cytomolecular identification of individual wheat-wheat chromosome arm associations in wheat-rye hybrids [PDF]
, 2013 Chromosome pairing in the meiotic metaphase I of wheatrye hybrids has been characterized by sequential genomic and fluorescent in situ hybridization allowing not only the discrimination of wheat and rye chromosomes, but also the identification of the
Badaeva ED +56 more
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Optimizing the design of oligonucleotides for homology directed gene targeting. [PDF]
PLoS ONE, 2011 BACKGROUND: Gene targeting depends on the ability of cells to use homologous recombination to integrate exogenous DNA into their own genome. A robust mechanistic model of homologous recombination is necessary to fully exploit gene targeting for ...
Judith Miné-Hattab +4 more
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Somatic Pairing in Drosophila virilis Mitosis [PDF]
, 1975 In neuroblast cells homologous chromosomes tend to pair during prophase of mitosis. Heterochromatic elements of homologous chromosomes are widely separated in very early prophase, at which time the euchromatin is poorly stained.
Guest, William C.
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