Results 1 to 10 of about 12,965 (145)

Homologous Recombination Assay

Bio-Protocol, 2013
Repair of double strand break by homologous recombination was examined using U2OS cells or RG37 cells harbouring specific substrate developed by Puget et al. (2005) and Dumay et al.
Yvan Canitrot, Didier Trouche
doaj   +3 more sources

Homologous Recombination in Procaryotes [PDF]

Microbiological Reviews, 1988
Gerald R. Smith
  +7 more sources

Multi-scale characterisation of homologous recombination deficiency in breast cancer

Genome Medicine, 2023
Background Homologous recombination is a robust, broadly error-free mechanism of double-strand break repair, and deficiencies lead to PARP inhibitor sensitivity.
Daniel H. Jacobson, Shi Pan, Jasmin Fisher, Maria Secrier   +3 more
doaj   +1 more source

The histone modification reader ZCWPW1 promotes double-strand break repair by regulating cross-talk of histone modifications and chromatin accessibility at meiotic hotspots

Genome Biology, 2022
Background The PRDM9-dependent histone methylation H3K4me3 and H3K36me3 function in assuring accurate homologous recombination at recombination hotspots in mammals.
Shenli Yuan, Tao Huang, Ziyou Bao, Shiyu Wang, Xinyue Wu, Jiang Liu, Hongbin Liu, Zi-Jiang Chen   +7 more
doaj   +1 more source

Core genes can have higher recombination rates than accessory genes within global microbial populations

eLife, 2022
Recombination is essential to microbial evolution, and is involved in the spread of antibiotic resistance, antigenic variation, and adaptation to the host niche.
Asher Preska Steinberg, Mingzhi Lin, Edo Kussell   +2 more
doaj   +1 more source

BRCA2 and homologous recombination [PDF]

Breast Cancer Research, 2001
Two recent papers provide new evidence relevant to the role of the breast cancer susceptibility gene BRCA2 in DNA repair. Moynahan et al provide genetic data indicating a requirement for BRCA2 in homology-dependent (recombinational) repair of DNA double-strand breaks.
Brian J. Orelli, Douglas K. Bishop
openaire   +3 more sources

The Regulation of Homologous Recombination by Helicases [PDF]

Genes, 2020
Homologous recombination is essential for DNA repair, replication and the exchange of genetic material between parental chromosomes during meiosis. The stages of recombination involve complex reorganization of DNA structures, and the successful completion of these steps is dependent on the activities of multiple helicase enzymes.
Eric Huselid, Samuel F. Bunting
openaire   +2 more sources

Slow Replication Fork Velocity of Homologous Recombination-Defective Cells Results from Endogenous Oxidative Stress. [PDF]

PLoS Genetics, 2016
Replications forks are routinely hindered by different endogenous stresses. Because homologous recombination plays a pivotal role in the reactivation of arrested replication forks, defects in homologous recombination reveal the initial endogenous stress ...
Therese Wilhelm, Sandrine Ragu, Indiana Magdalou, Christelle Machon, Elodie Dardillac, Hervé Técher, Jérôme Guitton, Michelle Debatisse, Bernard S Lopez   +8 more
doaj   +1 more source

Homologous Recombination: Down to the Wire [PDF]

Current Biology, 2004
Exchange of strands between homologous DNA molecules is catalyzed by evolutionarily conserved recombinases. These proteins can occur in different quaternary arrangements: rings or helical filaments. Recent results reveal that recombinase function follows from the filamentous form.
Roland Kanaar, Claire Wyman
openaire   +3 more sources

Homologous recombination proficiency in ovarian and breast cancer patients

BMC Cancer, 2021
Homologous recombination and DNA repair are important for genome maintenance. Genetic variations in essential homologous recombination genes, including BRCA1 and BRCA2 results in homologous recombination deficiency (HRD) and can be a target for ...
Justin Fortune Creeden, Nisha S. Nanavaty, Katelyn R. Einloth, Cassidy E. Gillman, Laura Stanbery, Danae M. Hamouda, Lance Dworkin, John Nemunaitis   +7 more
doaj   +1 more source