Homologous Recombination: To Fork and Beyond [PDF]
Genes, 2018 Accurate completion of genome duplication is threatened by multiple factors that hamper the advance and stability of the replication forks. Cells need to tolerate many of these blocking lesions to timely complete DNA replication, postponing their repair ...
Prado Velasco, José Félix
core +7 more sources
Multi-scale characterisation of homologous recombination deficiency in breast cancer [PDF]
Genome Medicine, 2023 Background Homologous recombination is a robust, broadly error-free mechanism of double-strand break repair, and deficiencies lead to PARP inhibitor sensitivity.
Daniel H. Jacobson +3 more
doaj +2 more sources
Homologous recombination proficiency in ovarian and breast cancer patients
BMC Cancer, 2021 Homologous recombination and DNA repair are important for genome maintenance. Genetic variations in essential homologous recombination genes, including BRCA1 and BRCA2 results in homologous recombination deficiency (HRD) and can be a target for ...
Justin Fortune Creeden +7 more
doaj +2 more sources
Homologous Recombination in Negative Sense RNA Viruses [PDF]
Viruses, 2011 Recombination is an important process that influences biological evolution at many different levels. More and more homologous recombination events have been reported among negative sense RNA viruses recently.
Michael Worobey, Guan-Zhu Han
doaj +4 more sources
High fidelity of RecA-catalyzed recombination: a watchdog of genetic diversity [PDF]
Nucleic Acids Research, 2006, Vol. 34, No. 18 5021-5031, 2010 Homologous recombination plays a key role in generating genetic diversity, while maintaining protein functionality. The mechanisms by which RecA enables a single-stranded segment of DNA to recognize a homologous tract within a whole genome are poorly understood.
Sagi, Dror, Stavans, Joel, Tlusty, Tsvi
arxiv +9 more sources
No observed effect of homologous recombination on influenza C virus evolution [PDF]
Virology Journal, 2010 The occurrence of homologous recombination in influenza viruses has been under some debate recently. To determine the extent of homologous recombination in influenza C virus, recombination analyses of all available gene sequences of influenza C virus ...
Boni Maciej F, Han Guan-Zhu, Li Si-Shen
doaj +5 more sources
Mouse WRN Helicase Domain Is Not Required for Spontaneous Homologous Recombination-Mediated DNA Deletion [PDF]
Journal of Nucleic Acids, 2010 Werner syndrome is a rare disorder that manifests as premature aging and age-related diseases. WRN is the gene mutated in WS, and is one of five human RecQ helicase family members.
Adam D. Brown +2 more
doaj +4 more sources
Homologous recombination deficiency in ovarian cancer: a review of its epidemiology and management
Clinics, 2018 Ovarian cancer patients with homologous recombination deficiencies exhibit specific clinical behaviors, and improved responses to treatments, such as platinum-based chemotherapy and poly (ADP-ribose) polymerase (PARP) inhibitors, have been observed ...
Renata Rodrigues da Cunha Colombo Bonadio +3 more
doaj +2 more sources
Pan-cancer landscape of homologous recombination deficiency
Nature Communications, 2020 Cancers deficient in homologous recombination can benefit from treatment with poly ADP-ribose polymerase (PARP) inhibitors. Here, the authors generated a classifier that can predict homologous recombination deficiency from genomic data and suggest ...
Luan Nguyen +3 more
doaj +2 more sources
Using single loxP sites to enhance homologous recombination: ts mutants in Sec1 of Dictyostelium discoideum. [PDF]
PLoS ONE, 2007 Dictyostelium discoideum amoebae are haploid and, as they share many features with animal cells, should be an ideal creature for studying basic processes such as cell locomotion.
Mark S Bretscher, Margaret Clotworthy
doaj +11 more sources