Results 1 to 10 of about 773,827 (377)

Homologous Recombination: To Fork and Beyond [PDF]

Genes, 2018
Accurate completion of genome duplication is threatened by multiple factors that hamper the advance and stability of the replication forks. Cells need to tolerate many of these blocking lesions to timely complete DNA replication, postponing their repair ...
Prado Velasco, José Félix
core   +7 more sources

Homologous recombination proficiency in ovarian and breast cancer patients

BMC Cancer, 2021
Homologous recombination and DNA repair are important for genome maintenance. Genetic variations in essential homologous recombination genes, including BRCA1 and BRCA2 results in homologous recombination deficiency (HRD) and can be a target for ...
Justin Fortune Creeden, Nisha S. Nanavaty, Katelyn R. Einloth, Cassidy E. Gillman, Laura Stanbery, Danae M. Hamouda, Lance Dworkin, John Nemunaitis   +7 more
doaj   +2 more sources

Structural basis of homologous recombination [PDF]

Cellular and Molecular Life Sciences, 2019
Homologous recombination (HR) is a pathway to faithfully repair DNA double-strand breaks (DSBs). At the core of this pathway is a DNA recombinase, which, as a nucleoprotein filament on ssDNA, pairs with homologous DNA as a template to repair the damaged ...
Yueru Sun, T. J. McCorvie, L. Yates, Xiaodong Zhang   +3 more
semanticscholar   +4 more sources

Homologous Recombination Assay

Bio-Protocol, 2013
Repair of double strand break by homologous recombination was examined using U2OS cells or RG37 cells harbouring specific substrate developed by Puget et al. (2005) and Dumay et al.
Yvan Canitrot, Didier Trouche
doaj   +3 more sources

Homologous recombination deficiency in ovarian cancer: a review of its epidemiology and management

Clinics, 2018
Ovarian cancer patients with homologous recombination deficiencies exhibit specific clinical behaviors, and improved responses to treatments, such as platinum-based chemotherapy and poly (ADP-ribose) polymerase (PARP) inhibitors, have been observed ...
Renata Rodrigues da Cunha Colombo Bonadio, Rodrigo Nogueira Fogace, Vanessa Costa Miranda, Maria del Pilar Estevez Diz   +3 more
doaj   +2 more sources

Pan-cancer landscape of homologous recombination deficiency

Nature Communications, 2020
Cancers deficient in homologous recombination can benefit from treatment with poly ADP-ribose polymerase (PARP) inhibitors. Here, the authors generated a classifier that can predict homologous recombination deficiency from genomic data and suggest ...
Luan Nguyen, John W. M. Martens, Arne Van Hoeck, Edwin Cuppen   +3 more
doaj   +2 more sources

Homologous recombination deficiency among patients with germline or somatic non-BRCA1/2 homologous recombination repair gene variations [PDF]

npj Precision Oncology
This study examined the relationship between homologous recombination deficiency (HRD) and variations in non-BRCA1/2 homologous recombination repair (HRR) genes.
Yue Li, Xinhua Yang, Haoyang Cai, Fang Wang   +3 more
doaj   +2 more sources

UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors [PDF]

Cell, 2020
Genomic instability can be a hallmark of both human genetic disease and cancer. We identify a deleterious UBQLN4 mutation in families with an autosomal recessive syndrome reminiscent of genome instability disorders.
Beleggia, Filippo, Bustos, Matias A., Checa Rodríguez, Cintia, Goergens, Jonas, Huertas Sánchez, Pablo, Isensee, Jörg, Jachimowicz, Ron D., Velpula, Bhagya Bhavana   +7 more
core   +2 more sources

Homologous recombination in procaryotes. [PDF]

Microbiological Reviews, 1988
Gerald R. Smith
  +7 more sources

Homologous recombination risk in baculovirus expression vector system

Virus Research, 2022
The baculovirus expression vector system (BEVS) is widely used for producing recombinant proteins. To achieve high expression level of recombinant proteins, baculoviral elements, such as enhancers, promoters, signal peptide coding sequences and 3′-UTR ...
Jianan Huang, Huanlei Liu, Xiaodong Xu
doaj   +1 more source