Results 251 to 260 of about 345,396 (332)

Homologous recombination and evolutionary arms race drive the adaptive evolution of African swine fever virus. [PDF]

Vet Res
Wang W, Liu Q, Zhao Q, Zhu Z, Wen W, Zhang Z, Li X.   +6 more
europepmc   +1 more source

Role of the Choline‐Binding Protein A in the Ability of Porcine Ligilactobacillus salivarius FFIG58 to Modulate TLR3‐Mediated Intestinal Antiviral Immunity

Food Frontiers, EarlyView.
The choline‐binding protein A (CbpA) was shown to mediate adhesion of probiotic Ligilactobacillus salivarius strains to human intestinal epithelial cells (IECs). A knockout mutant lacking the CbpA protein derived from the immunomodulatory porcine strain L. salivarius FFIG58 was obtained. The CbpA is a key surface protein of L.
Yoshiya Imamura, Hikari Yamamuro, Mariano Elean, Lorena Paola Arce, Ryutaro Funabashi, Fernanda Raya Tonetti, Kohtaro Fukuyama, Mikado Tomokiyo, Fu Namai, Sudeb Saha, Wakako Ikeda‐Ohtsubo, Keita Nishiyama, Julio Villena, Haruki Kitazawa   +13 more
wiley   +1 more source

Homologous recombination shapes the architecture and evolution of bacterial genomes. [PDF]

Nucleic Acids Res
Torrance EL, Diop A, Bobay LM.
europepmc   +1 more source

Protocol for Constructing a Gene Knockout in Pseudomonas Using pT18mobsacB

Food Safety and Health, EarlyView.
A streamlined protocol for scarless gene knockout in Pseudomonas using the tetracycline‐resistant suicide plasmid pT18mobsacB is presented. The method enables efficient two‐step allelic exchange and is broadly applicable to Gram‐negative bacteria. ABSTRACT Gene knockout via homologous recombination is a powerful approach for investigating gene function
Han Yang, Manxi Wu, Jinping Cao, Chongde Sun, Yue Wang   +4 more
wiley   +1 more source

Comprehensive RAD51C ovarian cancer variant analysis uncouples homologous recombination and replicative functions. [PDF]

Nat Commun
Rein HL, Rawal Y, Palovcak-Lightbourn AL, Ganesan GS, Parker PS, Russell R, Darrah KE, Afsar M, Sullivan MR, Hengel SR, Radke MR, Opresko PL, Yanowitz JL, Greene EC, Lee JM, Domchek SM, Swisher EM, Olsen SK, Sung P, Bernstein KA.   +19 more
europepmc   +1 more source

Curcumin Induces Homologous Recombination Deficiency by BRCA2 Degradation in Breast Cancer and Normal Cells. [PDF]

Cancers (Basel)
Komar ZM, Ladan MM, Verkaik NS, Dahmani A, Montaudon E, Marangoni E, Kanaar R, Nonnekens J, Houtsmuller AB, Jager A, Gent DCV.   +10 more
europepmc   +1 more source

[An homologous recombination strategy to directly clone mammalian telomeres]. Progress report

, 1994
Geoffrey M. Wahl
openalex   +2 more sources

Breast carcinomas associated with microglandular adenosis are linked to germline alterations in homologous recombination-deficiency genes. [PDF]

NPJ Breast Cancer
Schwartz CJ, Genco I, Repetto M, Muldoon D, Gazzo A, Terraf P, Grabenstetter A, Ross D, Zhang H, Mandelker D, Powell S, Weigelt B, Bandlamudi C, Brogi E, Pareja F, Wen HY.   +15 more
europepmc   +1 more source

Epigenomics‐guided precision oncology: Chromatin variants in prostate tumor evolution

International Journal of Cancer, EarlyView.
Abstract Prostate cancer is a common malignancy that in 5%–30% leads to treatment‐resistant and highly aggressive disease. Metastasis‐potential and treatment‐resistance is thought to rely on increased plasticity of the cancer cells—a mechanism whereby cancer cells alter their identity to adapt to changing environments or therapeutic pressures to create
Kira Furlano, Tina Keshavarzian, Nadine Biernath, Annika Fendler, Maria de Santis, Joachim Weischenfeldt, Mathieu Lupien   +6 more
wiley   +1 more source

Comprehensive assessment of homologous recombination deficiency via simultaneous methylation and mutation analysis in epithelial ovarian cancer: implications for PARP inhibitors efficacy. [PDF]

Biomark Res
Dong L, Wu H, Li N, Li W, Song Y, Xiong Y, Yin H, Fang H, Chen R, Yi X, Huang J, Ying J.   +11 more
europepmc   +1 more source