Results 251 to 260 of about 789,870 (314)

Comprehensive genomic profiling for homologous recombination deficiency guides PARP inhibitor therapy recommendations in ovarian cancer. [PDF]

Pathol Oncol Res
Inci A, Witzel I, Moch H, Rahmani-Khajouei S, Zoche M, Samartzis EP.   +5 more
europepmc   +1 more source

Functional validation of a white pupae minimal gene construct in Ceratitis capitata (Diptera: Tephritidae)

Insect Science, EarlyView.
An intronless version of the white pupae (wp) gene was engineered to restore the wild type brown puparium color in white pupae phenotype mutants of the Mediterranean fruit fly, Ceratitis capitata. Functionality of the minimal gene version (mini‐wp) was verified in vivo, as one copy of mini‐wp successfully restored the wild type phenotype in homozygous ...
Lucas Henrique Figueiredo Prates, Roswitha A. Aumann, Inga Sievers, Tanja Rehling, Marc F. Schetelig   +4 more
wiley   +1 more source

The distinct landscape of tumor immune microenvironment in homologous recombination deficient cancers. [PDF]

Biomark Res
Xu Q, Wen Y, Huang T, Li H, Liu X, Shi SN, Gong W, Mills GB, Ma D, Gao Q, Fang Y.   +10 more
europepmc   +1 more source

Molecular mechanisms of sex determination in Lepidoptera: current status and perspectives

Insect Science, EarlyView.
The genetic basis of sex determination in Lepidoptera was discovered in 2014 in the silkworm Bombyx mori. In this model species, the W chromosome‐derived small piRNA called Fem piRNA downregulates the expression of a Z‐linked gene, Masculinizer (Masc), which leads to the default female‐specific splicing of the doublesex gene (dsxF) and thus to female ...
František Marec, Atsuo Yoshido, Arjen E. van′t Hof   +2 more
wiley   +1 more source

Phosphorylation of RNF213 by ATM-mediated ubiquitination of RPA1 regulates homologous recombination repair and chemosensitivity. [PDF]

Cell Death Dis
Hu D, Wu W, Wu C, Li J, Ruan B, Cheng H, Jiang Y, Wang Y, Song Z.   +8 more
europepmc   +1 more source

Sequence and expression analysis of potential spermatogenesis‐specific gene cognates in the Caribbean fruit fly, Anastrepha suspensa

Insect Science, EarlyView.
Abstract The sterile insect technique (SIT) is a highly effective biologically‐based method for the suppression of many insect pest populations. SIT efficacy could be improved by methods of male sterilization that avoid the use of irradiation that can result in diminished fitness and mating competitiveness.
Alfred M. Handler, Richard B. Furlong, Chao Chen, Daniel A. Hahn   +3 more
wiley   +1 more source

Homologous Recombination Deficiency in Ovarian and Breast Cancers: Biomarkers, Diagnosis, and Treatment. [PDF]

Curr Issues Mol Biol
Shah B, Hussain M, Seth A.
europepmc   +1 more source

Development and evaluation of pupal color‐based genetic sexing strains in Anastrepha obliqua (Diptera: Tephritidae)

Insect Science, EarlyView.
Two spontaneous mutations in pupae of the West Indian fruit fly Anastrepha obliqua, named bp and sp, were isolated and studied. The bp mutation was selected, and using two types of Y‐autosoma l translocation inducers and an appropriate crossing scheme, two genetically sexed strains based on pupa l color were developed for the first time in this species,
Daisy P. Cárdenas‐Enríquez, Víctor García‐Martínez, Jorge Ibáñez‐Palacios, Brenda Torres‐Huerta, Maria F. Ruiz‐Pérez, José S. Meza   +5 more
wiley   +1 more source