Results 31 to 40 of about 348,739 (321)

Mutations in pathways depending on BRCA1 and BRCA2 may increase cancer risks from an environmental carcinogen [PDF]

, 2011
Recently, the President’s Cancer Panel [2008-2009] protested that preventive action is not taken when uncertainty exists about potential harm from a chemical, because the US regulatory approach demands that a hazard be incontrovertibly ...
Bernard Friedenson
core   +2 more sources

Smc5/6 maintains stalled replication forks in a recombination-competent conformation [PDF]

, 2009
The Smc5/6 structural maintenance of chromosomes complex is required for efficient homologous recombination (HR). Defects in Smc5/6 result in chromosome missegregation and fragmentation.
Ampatzidou, Eleni, Irmisch, Anja, Mizuno, Ken'ichi, Murray, Johanne M, O'Connell, Matthew J   +4 more
core   +2 more sources

Mouse WRN Helicase Domain Is Not Required for Spontaneous Homologous Recombination-Mediated DNA Deletion

Journal of Nucleic Acids, 2010
Werner syndrome is a rare disorder that manifests as premature aging and age-related diseases. WRN is the gene mutated in WS, and is one of five human RecQ helicase family members.
Adam D. Brown, Alison B. Claybon, Alexander J. R. Bishop   +2 more
doaj   +1 more source

Improved Gene Targeting through Cell Cycle Synchronization. [PDF]

PLoS ONE, 2015
Gene targeting is a challenge in organisms where non-homologous end-joining is the predominant form of recombination. We show that cell division cycle synchronization can be applied to significantly increase the rate of homologous recombination during ...
Vasiliki Tsakraklides, Elena Brevnova, Gregory Stephanopoulos, A Joe Shaw   +3 more
doaj   +1 more source

The Landscape of Realized Homologous Recombination in Pathogenic Bacteria [PDF]

, 2015
Recombination enhances the adaptive potential of organisms by allowing genetic variants to be tested on multiple genomic backgrounds. Its distribution in the genome can provide insight into the evolutionary forces that underlie traits, such as the ...
Didelot, X, Falush, D, Jolley, KA, Kobayashi, I, Maiden, MCJ, Sheppard, SK, Yahara, K   +6 more
core   +2 more sources

Bacterial microevolution and the Pangenome [PDF]

, 2020
The comparison of multiple genome sequences sampled from a bacterial population reveals considerable diversity in both the core and the accessory parts of the pangenome.
A Bankevich, AE Darling, AE Darling, AJ Page, AO Kislyuk, B Charlesworth, C Buckee, C Collins, C Wiuf, CM Thomas, CS Pepperell, DJ Wilson, DR Zerbino, E Jacox, F Lassalle, GE Sims, GJ Szollosi, GJ Szollosi, GJ Szollosi, H Ochman, IJ Wilson, J Hedge, J Lawrence, JB Joy, JFC Kingman, KAA Jolley, KE Dingle, KT Konstantinidis, L Li, L Petersen, M Csurös, M Nordborg, M Pagel, M Steinegger, M Touchon, M Vos, M Vos, M Vos, MJ Ward, MTG Holden, NA Rosenberg, NJ Croucher, P Donnelly, PAP Moran, R Griffiths, RC Griffiths, RG Everitt, RK Aziz, S Castillo-Ramírez, S Kurtz, S Wright, SF Altschul, SK Sheppard, SK Sheppard, SS Abby, SV Angiuoli, T Ohta, T Seemann, TG Vaughan, WP Maddison, X Didelot, X Didelot, X Didelot, X Didelot, X Didelot, X Didelot, X Didelot, Z Yang, Z Zhou   +68 more
core   +1 more source

Using single loxP sites to enhance homologous recombination: ts mutants in Sec1 of Dictyostelium discoideum.

PLoS ONE, 2007
BackgroundDictyostelium discoideum amoebae are haploid and, as they share many features with animal cells, should be an ideal creature for studying basic processes such as cell locomotion.
Mark S Bretscher, Margaret Clotworthy
doaj   +1 more source

Reconstitution of recombination-associated DNA synthesis with human proteins. [PDF]

, 2013
The repair of DNA breaks by homologous recombination is a high-fidelity process, necessary for the maintenance of genome integrity. Thus, DNA synthesis associated with recombinational repair must be largely error-free.
Grossi, Sara M, Heyer, Wolf-Dietrich, Hurwitz, Jerard, Sneeden, Jessica L, Tappin, Inger   +4 more
core   +1 more source

Mutational Effects of Mobile Introns on the Mitochondrial Genomes of Metschnikowia Yeasts

Frontiers in Genetics, 2021
It has been argued that DNA repair by homologous recombination in the context of endonuclease-mediated cleavage can cause mutations. To better understand this phenomenon, we examined homologous recombination following endonuclease cleavage in a native ...
Scout R. L. Thompson, Dong Kyung Lee, Marc-André Lachance, David Roy Smith   +3 more
doaj   +1 more source

Homologous Recombination: Down to the Wire [PDF]

Current Biology, 2004
Exchange of strands between homologous DNA molecules is catalyzed by evolutionarily conserved recombinases. These proteins can occur in different quaternary arrangements: rings or helical filaments. Recent results reveal that recombinase function follows from the filamentous form.
Wyman, C.L., Kanaar, Roland
openaire   +2 more sources