Results 41 to 50 of about 789,870 (314)

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination in sister chromatids

Nature Cell Biology, 2019
Genotoxic DNA double-strand breaks (DSBs) can be repaired by error-free homologous recombination (HR) or mutagenic non-homologous end-joining1. HR supresses tumorigenesis1, but is restricted to the S and G2 phases of the cell cycle when a sister ...
Kyosuke Nakamura, Giulia Saredi, Giulia Saredi, Jordan R. Becker, B. Foster, Nhuong V. Nguyen, Nhuong V. Nguyen, Tracey E. Beyer, Laura C Cesa, P. Faull, Saulius Lukauskas, T. Frimurer, J. R. Chapman, Till Bartke, Anja Groth   +14 more
semanticscholar   +1 more source

Mouse WRN Helicase Domain Is Not Required for Spontaneous Homologous Recombination-Mediated DNA Deletion

Journal of Nucleic Acids, 2010
Werner syndrome is a rare disorder that manifests as premature aging and age-related diseases. WRN is the gene mutated in WS, and is one of five human RecQ helicase family members.
Adam D. Brown, Alison B. Claybon, Alexander J. R. Bishop   +2 more
doaj   +1 more source

SUMOylation of Rad52-Rad59 synergistically change the outcome of mitotic recombination [PDF]

, 2016
Homologous recombination (HR) is essential for maintenance of genome stability through double-strand break (DSB) repair, but at the same time HR can lead to loss of heterozygosity and uncontrolled recombination can be genotoxic.
Lisby, Michael, Silva, Sonia
core   +1 more source

Bacterial microevolution and the Pangenome [PDF]

, 2020
The comparison of multiple genome sequences sampled from a bacterial population reveals considerable diversity in both the core and the accessory parts of the pangenome.
A Bankevich, AE Darling, AE Darling, AJ Page, AO Kislyuk, B Charlesworth, C Buckee, C Collins, C Wiuf, CM Thomas, CS Pepperell, DJ Wilson, DR Zerbino, E Jacox, F Lassalle, GE Sims, GJ Szollosi, GJ Szollosi, GJ Szollosi, H Ochman, IJ Wilson, J Hedge, J Lawrence, JB Joy, JFC Kingman, KAA Jolley, KE Dingle, KT Konstantinidis, L Li, L Petersen, M Csurös, M Nordborg, M Pagel, M Steinegger, M Touchon, M Vos, M Vos, M Vos, MJ Ward, MTG Holden, NA Rosenberg, NJ Croucher, P Donnelly, PAP Moran, R Griffiths, RC Griffiths, RG Everitt, RK Aziz, S Castillo-Ramírez, S Kurtz, S Wright, SF Altschul, SK Sheppard, SK Sheppard, SS Abby, SV Angiuoli, T Ohta, T Seemann, TG Vaughan, WP Maddison, X Didelot, X Didelot, X Didelot, X Didelot, X Didelot, X Didelot, X Didelot, Z Yang, Z Zhou   +68 more
core   +1 more source

Reconstitution of recombination-associated DNA synthesis with human proteins. [PDF]

, 2013
The repair of DNA breaks by homologous recombination is a high-fidelity process, necessary for the maintenance of genome integrity. Thus, DNA synthesis associated with recombinational repair must be largely error-free.
Grossi, Sara M, Heyer, Wolf-Dietrich, Hurwitz, Jerard, Sneeden, Jessica L, Tappin, Inger   +4 more
core   +1 more source

PARP Inhibitors as a Therapeutic Agent for Homologous Recombination Deficiency in Breast Cancers

Journal of Clinical Medicine, 2019
Poly (ADP-ribose) polymerases (PARPs) play an important role in various cellular processes, such as replication, recombination, chromatin remodeling, and DNA repair.
M. Y. Keung, Yanyuan Wu, J. Vadgama
semanticscholar   +1 more source

Improved Gene Targeting through Cell Cycle Synchronization. [PDF]

PLoS ONE, 2015
Gene targeting is a challenge in organisms where non-homologous end-joining is the predominant form of recombination. We show that cell division cycle synchronization can be applied to significantly increase the rate of homologous recombination during ...
Vasiliki Tsakraklides, Elena Brevnova, Gregory Stephanopoulos, A Joe Shaw   +3 more
doaj   +1 more source

The BRCA Tumor Suppressor Network in Chromosome Damage Repair by Homologous Recombination.

Annual Review of Biochemistry, 2019
Mutations in the BRCA1 and BRCA2 genes predispose afflicted individuals to breast, ovarian, and other cancers. The BRCA-encoded products form complexes with other tumor suppressor proteins and with the recombinase enzyme RAD51 to mediate chromosome ...
Weixing Zhao, C. Wiese, Youngho Kwon, R. Hromas, P. Sung   +4 more
semanticscholar   +1 more source

Using single loxP sites to enhance homologous recombination: ts mutants in Sec1 of Dictyostelium discoideum.

PLoS ONE, 2007
BackgroundDictyostelium discoideum amoebae are haploid and, as they share many features with animal cells, should be an ideal creature for studying basic processes such as cell locomotion.
Mark S Bretscher, Margaret Clotworthy
doaj   +1 more source

BRCA2 and homologous recombination [PDF]

Breast Cancer Research, 2001
Two recent papers provide new evidence relevant to the role of the breast cancer susceptibility gene BRCA2 in DNA repair. Moynahan et al provide genetic data indicating a requirement for BRCA2 in homology-dependent (recombinational) repair of DNA double-strand breaks.
B J, Orelli, D K, Bishop
openaire   +2 more sources