Bacterial microevolution and the Pangenome [PDF]
, 2020 The comparison of multiple genome sequences sampled from a bacterial population reveals considerable diversity in both the core and the accessory parts of the pangenome.
A Bankevich +68 more
core +1 more source
Mutational Effects of Mobile Introns on the Mitochondrial Genomes of Metschnikowia Yeasts
Frontiers in Genetics, 2021 It has been argued that DNA repair by homologous recombination in the context of endonuclease-mediated cleavage can cause mutations. To better understand this phenomenon, we examined homologous recombination following endonuclease cleavage in a native ...
Scout R. L. Thompson +3 more
doaj +1 more source
Reconstitution of recombination-associated DNA synthesis with human proteins. [PDF]
, 2013 The repair of DNA breaks by homologous recombination is a high-fidelity process, necessary for the maintenance of genome integrity. Thus, DNA synthesis associated with recombinational repair must be largely error-free.
Grossi, Sara M +4 more
core +1 more source
UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors [PDF]
, 2020 Genomic instability can be a hallmark of both human genetic disease and cancer. We identify a deleterious UBQLN4 mutation in families with an autosomal recessive syndrome reminiscent of genome instability disorders.
Beleggia, Filippo +7 more
core +1 more source
Competition between replicative and translesion polymerases during homologous recombination repair in Drosophila. [PDF]
PLoS Genetics, 2012 In metazoans, the mechanism by which DNA is synthesized during homologous recombination repair of double-strand breaks is poorly understood. Specifically, the identities of the polymerase(s) that carry out repair synthesis and how they are recruited to ...
Daniel P Kane +3 more
doaj +1 more source
Nature Communications, 2017 The choice between homologous recombination and non-homologous end-joining is largely influenced by cell cycle. Here the authors show that APCCdh1 promotes homologous recombination by removing USP1, allowing polyubiquitinated histones to recruit BRCA1.
Kyungsoo Ha +15 more
doaj +1 more source
Measuring Homologous Recombination Rates between Chromosomal Locations in Salmonella
Bio-Protocol, 2019 Homologous recombination between two similar DNA molecules, plays an important role in the repair of double-stranded DNA breaks. Recombination can occur between two sister chromosomes, or between two locations of similar sequence identity within the same
Gerrit Brandis +2 more
doaj +1 more source
Role of the Schizosaccharomyces pombe F-box DNA helicase in processing recombination intermediates. [PDF]
, 2005 In an effort to identify novel genes involved in recombination repair, we isolated fission yeast Schizosaccharomyces pombe mutants sensitive to methyl methanesulfonate (MMS) and a synthetic lethal with rad2.
Carr, Antony M +6 more
core +2 more sources
Plant DNA Recombinases: A Long Way to Go
Journal of Nucleic Acids, 2010 DNA homologous recombination is fundamental process by which two homologous DNA molecules exchange the genetic information for the generation of genetic diversity and maintain the genomic integrity.
Rajani Kant Chittela +1 more
doaj +1 more source
Homologous recombination is unlikely to play a major role in influenza B virus evolution
Virology Journal, 2008 Influenza B viruses cause a significant amount of morbidity and mortality. The occurrence of homologous recombination in influenza viruses is controversial.
Liu Xi-Ping, Han Guan-Zhu, Li Si-Shen
doaj +1 more source