Results 41 to 50 of about 348,739 (321)

The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites

Nature Communications, 2017
The choice between homologous recombination and non-homologous end-joining is largely influenced by cell cycle. Here the authors show that APCCdh1 promotes homologous recombination by removing USP1, allowing polyubiquitinated histones to recruit BRCA1.
Kyungsoo Ha, Chengxian Ma, Han Lin, Lichun Tang, Zhusheng Lian, Fang Zhao, Ju-Mei Li, Bei Zhen, Huadong Pei, Suxia Han, Marcos Malumbres, Jianping Jin, Huan Chen, Yongxiang Zhao, Qing Zhu, Pumin Zhang   +15 more
doaj   +1 more source

Measuring Homologous Recombination Rates between Chromosomal Locations in Salmonella

Bio-Protocol, 2019
Homologous recombination between two similar DNA molecules, plays an important role in the repair of double-stranded DNA breaks. Recombination can occur between two sister chromosomes, or between two locations of similar sequence identity within the same
Gerrit Brandis, Sha Cao, Diarmaid Hughes   +2 more
doaj   +1 more source

V_H replacement in rearranged immunoglobulin genes [PDF]

, 2005
Examples suggesting that all or part of the V_H segment of a rearranged V_HDJ_H may be replaced by all or part of another V_H have been appearing since the 1980s ...
Brokaw JL, Cascalho M, Choi Y, Chukwuocha RU, Covey LR, Cuomo CA, Deane M, Golub R, Han JO, Hesse JE, Kleinfield RW, Kobrin CB, Lewis SM, Ramsden DA, Rosenquist R, Shiokawa S, Sims GP, Steenbergen EJ, Steenbergen EJ, Taki S, Wasserman R, Wasserman R   +21 more
core   +2 more sources

Plant DNA Recombinases: A Long Way to Go

Journal of Nucleic Acids, 2010
DNA homologous recombination is fundamental process by which two homologous DNA molecules exchange the genetic information for the generation of genetic diversity and maintain the genomic integrity.
Rajani Kant Chittela, Jayashree K. Sainis   +1 more
doaj   +1 more source

Homologous recombination is unlikely to play a major role in influenza B virus evolution

Virology Journal, 2008
Influenza B viruses cause a significant amount of morbidity and mortality. The occurrence of homologous recombination in influenza viruses is controversial.
Liu Xi-Ping, Han Guan-Zhu, Li Si-Shen
doaj   +1 more source

Replication dynamics of recombination-dependent replication forks

Nature Communications, 2021
Replication forks that are stalled at obstacles on the DNA template can be restarted by homologous recombination. Here, the authors show replication dynamics during homologous recombination-dependent replication fork restart by combining polymerase usage
Karel Naiman, Eduard Campillo-Funollet, Adam T. Watson, Alice Budden, Izumi Miyabe, Antony M. Carr   +5 more
doaj   +1 more source

Arabidopsis RecQl4A suppresses homologous recombination and modulates DNA damage responses [PDF]

, 2005
The DNA damage response and DNA recombination are two interrelated mechanisms involved in maintaining the integrity of the genome, but in plants they are poorly understood.
Bachrati, Bagherieh-Najjar, Bai, Blackburn, Bundock, Cohen, Courcelle, Cromie, De Silva, Dellaporta, Ellis, Fitzgerald, Frei, Gallego, Gallego, Gallego, Gherbi, Gray, Hanada, Hanin, Harrigan, Hartung, Henson, Imamura, Jackson, Jacques Hille, Johnson, Kitao, Krysan, Li, Lovett, Lowndes, McGlynn, McHugh, Mengiste, Michel, Mohammad B. Bagherieh-Najjar, Nakayama, Nakayama, Nugent, Onno M.H. Vries, Osborn, Pastink, Paul P. Dijkwel, Pierce, Puchta, Reiss, Riha, Riha, Rothstein, Sambrook, Seigneur, Sengupta, Sessions, Simon, Sinclair, Sladek, Sundaresan, Swoboda, Tercero, Ui, Valvekens, Watt, Wu, Yamagata   +64 more
core   +3 more sources

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source

Competition between replicative and translesion polymerases during homologous recombination repair in Drosophila. [PDF]

PLoS Genetics, 2012
In metazoans, the mechanism by which DNA is synthesized during homologous recombination repair of double-strand breaks is poorly understood. Specifically, the identities of the polymerase(s) that carry out repair synthesis and how they are recruited to ...
Daniel P Kane, Michael Shusterman, Yikang Rong, Mitch McVey   +3 more
doaj   +1 more source

High-resolution mapping of heteroduplex DNA formed during UV-induced and spontaneous mitotic recombination events in yeast. [PDF]

, 2017
In yeast, DNA breaks are usually repaired by homologous recombination (HR). An early step for HR pathways is formation of a heteroduplex, in which a single-strand from the broken DNA molecule pairs with a strand derived from an intact DNA molecule.
Dominska, Margaret, Petes, Thomas D, Yim, Eunice, Yin, Yi   +3 more
core   +3 more sources