Results 41 to 50 of about 773,827 (377)

Homolog pairing during meiosis : dyneins on the move [PDF]

, 2010
Meiosis is a specialized form of cell division that generates haploid gametes from diploid cells. This is achieved by having 1 round of DNA replication followed by 2 rounds of nuclear division.
Arumugam, Prakash
core   +1 more source

Homologous Recombination Deficiency

Definitions, 2020
A DNA repair abnormality caused by mutations in one or more genes that are involved in homologous recombination repair. Deficient homologous recombination is associated with numerous neoplastic diseases and developmental disorders related to chromosomal ...

semanticscholar   +1 more source

Mutations in pathways depending on BRCA1 and BRCA2 may increase cancer risks from an environmental carcinogen [PDF]

, 2011
Recently, the President’s Cancer Panel [2008-2009] protested that preventive action is not taken when uncertainty exists about potential harm from a chemical, because the US regulatory approach demands that a hazard be incontrovertibly ...
Bernard Friedenson
core   +2 more sources

Improved Gene Targeting through Cell Cycle Synchronization. [PDF]

PLoS ONE, 2015
Gene targeting is a challenge in organisms where non-homologous end-joining is the predominant form of recombination. We show that cell division cycle synchronization can be applied to significantly increase the rate of homologous recombination during ...
Vasiliki Tsakraklides, Elena Brevnova, Gregory Stephanopoulos, A Joe Shaw   +3 more
doaj   +1 more source

The Landscape of Realized Homologous Recombination in Pathogenic Bacteria [PDF]

, 2015
Recombination enhances the adaptive potential of organisms by allowing genetic variants to be tested on multiple genomic backgrounds. Its distribution in the genome can provide insight into the evolutionary forces that underlie traits, such as the ...
Didelot, X, Falush, D, Jolley, KA, Kobayashi, I, Maiden, MCJ, Sheppard, SK, Yahara, K   +6 more
core   +2 more sources

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination in sister chromatids

Nature Cell Biology, 2019
Genotoxic DNA double-strand breaks (DSBs) can be repaired by error-free homologous recombination (HR) or mutagenic non-homologous end-joining1. HR supresses tumorigenesis1, but is restricted to the S and G2 phases of the cell cycle when a sister ...
Kyosuke Nakamura, Giulia Saredi, Giulia Saredi, Jordan R. Becker, B. Foster, Nhuong V. Nguyen, Nhuong V. Nguyen, Tracey E. Beyer, Laura C Cesa, P. Faull, Saulius Lukauskas, T. Frimurer, J. R. Chapman, Till Bartke, Anja Groth   +14 more
semanticscholar   +1 more source

Arabidopsis RecQl4A suppresses homologous recombination and modulates DNA damage responses [PDF]

, 2005
The DNA damage response and DNA recombination are two interrelated mechanisms involved in maintaining the integrity of the genome, but in plants they are poorly understood.
Bachrati, Bagherieh-Najjar, Bai, Blackburn, Bundock, Cohen, Courcelle, Cromie, De Silva, Dellaporta, Ellis, Fitzgerald, Frei, Gallego, Gallego, Gallego, Gherbi, Gray, Hanada, Hanin, Harrigan, Hartung, Henson, Imamura, Jackson, Jacques Hille, Johnson, Kitao, Krysan, Li, Lovett, Lowndes, McGlynn, McHugh, Mengiste, Michel, Mohammad B. Bagherieh-Najjar, Nakayama, Nakayama, Nugent, Onno M.H. Vries, Osborn, Pastink, Paul P. Dijkwel, Pierce, Puchta, Reiss, Riha, Riha, Rothstein, Sambrook, Seigneur, Sengupta, Sessions, Simon, Sinclair, Sladek, Sundaresan, Swoboda, Tercero, Ui, Valvekens, Watt, Wu, Yamagata   +64 more
core   +7 more sources

Mouse WRN Helicase Domain Is Not Required for Spontaneous Homologous Recombination-Mediated DNA Deletion

Journal of Nucleic Acids, 2010
Werner syndrome is a rare disorder that manifests as premature aging and age-related diseases. WRN is the gene mutated in WS, and is one of five human RecQ helicase family members.
Adam D. Brown, Alison B. Claybon, Alexander J. R. Bishop   +2 more
doaj   +1 more source

Prevalence of Homologous Recombination-Related Gene Mutations Across Multiple Cancer Types.

JCO Precision Oncology, 2018
Purpose The prevalence of homologous recombination DNA damage repair (HR-DDR) deficiencies among all tumor lineages is not well characterized. Therapy directed toward homologous recombination DDR deficiency (HRD) is now approved in ovarian and breast ...
Arielle L. Heeke, M. Pishvaian, F. Lynce, J. Xiu, J. Brody, Wang Chen, T. Baker, J. Marshall, C. Isaacs   +8 more
semanticscholar   +1 more source

Using single loxP sites to enhance homologous recombination: ts mutants in Sec1 of Dictyostelium discoideum.

PLoS ONE, 2007
BackgroundDictyostelium discoideum amoebae are haploid and, as they share many features with animal cells, should be an ideal creature for studying basic processes such as cell locomotion.
Mark S Bretscher, Margaret Clotworthy
doaj   +1 more source