Results 51 to 60 of about 773,827 (377)

Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells

Nature Cell Biology, 2018
BRCA1 deficiencies cause breast, ovarian, prostate and other cancers, and render tumours hypersensitive to poly(ADP-ribose) polymerase (PARP) inhibitors.
Harveer Dev, T. Chiang, C. Lescale, Inge de Krijger, Alistair G Martin, Domenic Pilger, J. Coates, Matylda Sczaniecka-Clift, Wenming Wei, Matthias Ostermaier, Mareike Herzog, Jonathan Lam, A. Shea, Mukerrem Demir, Qian Wu, Fengtang Yang, B. Fu, Z. Lai, G. Balmus, R. Belotserkovskaya, V. Serra, M. O’Connor, A. Bruna, Petra Beli, L. Pellegrini, C. Caldas, L. Deriano, J. Jacobs, Y. Galanty, S. Jackson   +29 more
semanticscholar   +1 more source

Reconstitution of recombination-associated DNA synthesis with human proteins. [PDF]

, 2013
The repair of DNA breaks by homologous recombination is a high-fidelity process, necessary for the maintenance of genome integrity. Thus, DNA synthesis associated with recombinational repair must be largely error-free.
Grossi, Sara M, Heyer, Wolf-Dietrich, Hurwitz, Jerard, Sneeden, Jessica L, Tappin, Inger   +4 more
core   +1 more source

Competition between replicative and translesion polymerases during homologous recombination repair in Drosophila. [PDF]

PLoS Genetics, 2012
In metazoans, the mechanism by which DNA is synthesized during homologous recombination repair of double-strand breaks is poorly understood. Specifically, the identities of the polymerase(s) that carry out repair synthesis and how they are recruited to ...
Daniel P Kane, Michael Shusterman, Yikang Rong, Mitch McVey   +3 more
doaj   +1 more source

Mutational Effects of Mobile Introns on the Mitochondrial Genomes of Metschnikowia Yeasts

Frontiers in Genetics, 2021
It has been argued that DNA repair by homologous recombination in the context of endonuclease-mediated cleavage can cause mutations. To better understand this phenomenon, we examined homologous recombination following endonuclease cleavage in a native ...
Scout R. L. Thompson, Dong Kyung Lee, Marc-André Lachance, David Roy Smith   +3 more
doaj   +1 more source

V_H replacement in rearranged immunoglobulin genes [PDF]

, 2005
Examples suggesting that all or part of the V_H segment of a rearranged V_HDJ_H may be replaced by all or part of another V_H have been appearing since the 1980s ...
Brokaw JL, Cascalho M, Choi Y, Chukwuocha RU, Covey LR, Cuomo CA, Deane M, Golub R, Han JO, Hesse JE, Kleinfield RW, Kobrin CB, Lewis SM, Ramsden DA, Rosenquist R, Shiokawa S, Sims GP, Steenbergen EJ, Steenbergen EJ, Taki S, Wasserman R, Wasserman R   +21 more
core   +2 more sources

The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites

Nature Communications, 2017
The choice between homologous recombination and non-homologous end-joining is largely influenced by cell cycle. Here the authors show that APCCdh1 promotes homologous recombination by removing USP1, allowing polyubiquitinated histones to recruit BRCA1.
Kyungsoo Ha, Chengxian Ma, Han Lin, Lichun Tang, Zhusheng Lian, Fang Zhao, Ju-Mei Li, Bei Zhen, Huadong Pei, Suxia Han, Marcos Malumbres, Jianping Jin, Huan Chen, Yongxiang Zhao, Qing Zhu, Pumin Zhang   +15 more
doaj   +1 more source

Measuring Homologous Recombination Rates between Chromosomal Locations in Salmonella

Bio-Protocol, 2019
Homologous recombination between two similar DNA molecules, plays an important role in the repair of double-stranded DNA breaks. Recombination can occur between two sister chromosomes, or between two locations of similar sequence identity within the same
Gerrit Brandis, Sha Cao, Diarmaid Hughes   +2 more
doaj   +1 more source

Smc5/6 maintains stalled replication forks in a recombination-competent conformation [PDF]

, 2009
The Smc5/6 structural maintenance of chromosomes complex is required for efficient homologous recombination (HR). Defects in Smc5/6 result in chromosome missegregation and fragmentation.
Ampatzidou, Eleni, Irmisch, Anja, Mizuno, Ken'ichi, Murray, Johanne M, O'Connell, Matthew J   +4 more
core   +2 more sources

PARP Inhibitors as a Therapeutic Agent for Homologous Recombination Deficiency in Breast Cancers

Journal of Clinical Medicine, 2019
Poly (ADP-ribose) polymerases (PARPs) play an important role in various cellular processes, such as replication, recombination, chromatin remodeling, and DNA repair.
M. Y. Keung, Yanyuan Wu, J. Vadgama
semanticscholar   +1 more source

Plant DNA Recombinases: A Long Way to Go

Journal of Nucleic Acids, 2010
DNA homologous recombination is fundamental process by which two homologous DNA molecules exchange the genetic information for the generation of genetic diversity and maintain the genomic integrity.
Rajani Kant Chittela, Jayashree K. Sainis   +1 more
doaj   +1 more source