Results 11 to 20 of about 137,677 (248)

Homologous recombination deficiency among patients with germline or somatic non-BRCA1/2 homologous recombination repair gene variations [PDF]

npj Precision Oncology
This study examined the relationship between homologous recombination deficiency (HRD) and variations in non-BRCA1/2 homologous recombination repair (HRR) genes.
Yue Li, Xinhua Yang, Haoyang Cai, Fang Wang   +3 more
doaj   +2 more sources

Breast carcinomas associated with microglandular adenosis are linked to germline alterations in homologous recombination-deficiency genes. [PDF]

NPJ Breast Cancer
Schwartz CJ, Genco I, Repetto M, Muldoon D, Gazzo A, Terraf P, Grabenstetter A, Ross D, Zhang H, Mandelker D, Powell S, Weigelt B, Bandlamudi C, Brogi E, Pareja F, Wen HY.   +15 more
europepmc   +3 more sources

Whole exome sequencing-based homologous recombination deficiency test for epithelial ovarian cancer [PDF]

Journal of Ovarian Research
Background The homologous recombination deficiency (HRD) test is an important tool for identifying patients with epithelial ovarian cancer (EOC) benefit from the treatment with poly(adenosine diphosphate-ribose) polymerase inhibitor (PARPi).
Ying-Cheng Chiang, Hsien-Neng Huang, Kuan-Ting Kuo, Wuh-Liang Hwu, Po-Han Lin   +4 more
doaj   +2 more sources

The progress and prospect of homologous recombination deficiency detection in clinical diagnosis and treatment of cancer [PDF]

Zhongguo aizheng zazhi, 2021
Homologous recombination (HR) is the main way to repair DNA double-stranded breaks, single-stranded DNA gaps and stagnation or folding replication forks, helping to maintain telomeres and ensure the correct segregation of chromosomes during meiosis ...
YU Li , SHEN Minna , JIANG Huiqin , WANG Beili , GUO Wei
doaj   +1 more source

Homologous recombination proficiency in ovarian and breast cancer patients

BMC Cancer, 2021
Homologous recombination and DNA repair are important for genome maintenance. Genetic variations in essential homologous recombination genes, including BRCA1 and BRCA2 results in homologous recombination deficiency (HRD) and can be a target for ...
Justin Fortune Creeden, Nisha S. Nanavaty, Katelyn R. Einloth, Cassidy E. Gillman, Laura Stanbery, Danae M. Hamouda, Lance Dworkin, John Nemunaitis   +7 more
doaj   +1 more source

Leveraging homologous recombination repair deficiency in sarcoma

EMBO Molecular Medicine, 2023
Personalised oncology is at the forefront of cancer research. The goal of personalised oncology is to selectively kill cancer cells while minimising side effects on normal tissue.
Dea Slade, Joanna I Loizou
doaj   +1 more source

Homologous Recombination Deficiency in Ovarian Cancer: from the Biological Rationale to Current Diagnostic Approaches

Journal of Personalized Medicine, 2023
The inability to efficiently repair DNA double-strand breaks using the homologous recombination repair pathway is defined as homologous recombination deficiency (HRD).
A. Mangogna, G. Munari, F. Pepe, Edoardo Maffii, P. Giampaolino, G. Ricci, M. Fassan, U. Malapelle, S. Biffi   +8 more
semanticscholar   +1 more source

Pms2 suppresses large expansions of the (GAA·TTC)n sequence in neuronal tissues [PDF]

, 2012
Copyright @ 2012 Bourn et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source ...
Chiranjeevi Sandi, David T. Kirkpatrick, Irene De Biase, Mark A. Pook, Rebecka L. Bourn, Ricardo Mouro Pinto, Sahar Al-Mahdawi, Sanjay I. Bidichandani   +7 more
core   +6 more sources

Homologous Recombination Deficiency in Ovarian, Breast, Colorectal, Pancreatic, Non-Small Cell Lung and Prostate Cancers, and the Mechanisms of Resistance to PARP Inhibitors

Frontiers in Oncology, 2022
Homologous recombination (HR) is a highly conserved DNA repair mechanism that protects cells from exogenous and endogenous DNA damage. Breast cancer 1 (BRCA1) and breast cancer 2 (BRCA2) play an important role in the HR repair pathway by interacting with
Negesse Mekonnen, Hobin Yang, Y. Shin
semanticscholar   +1 more source

Genomic and molecular landscape of homologous recombination deficiency across multiple cancer types

Scientific Reports, 2023
Homologous recombination deficiency (HRD) causes faulty double-strand break repair and is a prevalent cause of tumorigenesis. However, the incidence of HRD and its clinical significance in pan-cancer patients remain unknown.
Zhiwen Shi, Bolin Chen, Xiao Han, Weiyue Gu, Shuzhi Liang, Lin Wu   +5 more
semanticscholar   +1 more source