Results 31 to 40 of about 137,826 (378)

Homologous Recombination Deficiencies and Hereditary Tumors [PDF]

International Journal of Molecular Sciences, 2021
Homologous recombination (HR) is a vital process for repairing DNA double-strand breaks. Germline variants in the HR pathway, comprising at least 10 genes, such as BRCA1, BRCA2, ATM, BARD1, BRIP1, CHEK2, NBS1(NBN), PALB2, RAD51C, and RAD51D, lead to inherited susceptibility to specific types of cancers, including those of the breast, ovaries, prostate,
Hideki Yamamoto, Akira Hirasawa
openaire   +3 more sources

Biomarkers for Homologous Recombination Deficiency in Cancer [PDF]

Journal of Personalized Medicine, 2021
DNA double-strand breaks foster tumorigenesis and cell death. Two distinct mechanisms can be activated by the cell for DNA repair: the accurate mechanism of homologous recombination repair or the error-prone non-homologous end joining. Homologous Recombination Deficiency (HRD) is associated with sensitivity towards PARP inhibitors (PARPi) and its ...
Wagener-Ryczek, Svenja, Merkelbach-Bruse, Sabine, Siemanowski, Janna   +2 more
openaire   +2 more sources

Homologous recombination deficiency in breast cancer [PDF]

memo - Magazine of European Medical Oncology, 2020
SummaryBRCAmutation-related DNA repair deficiencies increase the individual sensitivity to DNA-targeting agents. Therefore, the patient’sBRCAmutational status is evaluated in clinical practice as a predictive marker in response to platinum salts and poly-ADP-ribose polymerase (PARP) inhibitors for breast cancer treatment.
Thomas Bartl, Alex Farr
openaire   +1 more source

Biomarkers for Homologous Recombination Deficiency in Cancer [PDF]

JNCI: Journal of the National Cancer Institute, 2018
Defective DNA repair is a common hallmark of cancer. Homologous recombination is a DNA repair pathway of clinical interest due to the sensitivity of homologous recombination-deficient cells to poly-ADP ribose polymerase (PARP) inhibitors. The measurement of homologous recombination deficiency (HRD) in cancer is therefore vital to the appropriate design
Michal M, Hoppe, Raghav, Sundar, David S P, Tan, Anand D, Jeyasekharan   +3 more
openaire   +2 more sources

Homologous Recombination Deficiency Scar: Mutations and Beyond—Implications for Precision Oncology [PDF]

Cancers, 2022
Homologous recombination deficiency (HRD) is a prevalent in approximately 17% of tumors and is associated with enhanced sensitivity to anticancer therapies inducing double-strand DNA breaks. Accurate detection of HRD would therefore allow improved patient selection and outcome of conventional and targeted anticancer therapies. However, current clinical
Alexander M. A. van der Wiel, Lesley Schuitmaker, Ying Cong, Jan Theys, Arne Van Hoeck, Conchita Vens, Philippe Lambin, Ala Yaromina, Ludwig J. Dubois   +8 more
openaire   +2 more sources

Distinct age-related effects of homologous recombination deficiency on genomic profiling and treatment efficacy in gastric cancer. [PDF]

J Gastroenterol
Maki Y, Kono Y, Ozato T, Yamamoto H, Hirasawa A, Ennishi D, Tomida S, Toyooka S, Hamada K, Iwamuro M, Kawano S, Otsuka M.   +11 more
europepmc   +3 more sources

Homologous recombination deficiency in ovarian cancer: a review of its epidemiology and management

Clinics, 2018
Ovarian cancer patients with homologous recombination deficiencies exhibit specific clinical behaviors, and improved responses to treatments, such as platinum-based chemotherapy and poly (ADP-ribose) polymerase (PARP) inhibitors, have been observed ...
Renata Rodrigues da Cunha Colombo Bonadio, Rodrigo Nogueira Fogace, Vanessa Costa Miranda, Maria del Pilar Estevez Diz   +3 more
doaj   +1 more source

DNAH2 facilitates the homologous recombination repair of Fanconi anemia pathway through modulating FANCD2 ubiquitination

Blood Science, 2021
. Fanconi anemia (FA), an X-linked genetic or autosomal recessive disease, exhibits complicated pathogenesis. Previously, we detected the mutated Dynein Axonemal Heavy Chain 2 (DNAH2) gene in 2 FA cases.
Lixian Chang, Xingjie Gao, Yuxia Wang, Chunmin Huang, Min Gao, Xiaomin Wang, Chao Liu, Wenqi Wu, Wenbin An, Yang Wan, Aoli Zhang, Yingchi Zhang, Weiping Yuan, Xiaofan Zhu   +13 more
doaj   +1 more source

Homologous recombination deficiency in pancreatic neuroendocrine tumors. [PDF]

Future Oncol
Aim: Pancreatic Neuroendocrine tumors (pNETs) are a heterogeneous group of neoplasms whose tumor biology is still little known. Thanks to next-generation sequencing, pathogenic mutations in base-excision-repair MUTYH gene and homologous recombination genes CHEK2 and BRCA2 seem to have a role in the development of pNETs.Research design & methods: We ...
Bardasi C, Tenedini E, Bonamici L, Benatti S, Bonetti LR, Luppi G, Cortesi L, Tagliafico E, Dominici M, Gelsomino F.   +9 more
europepmc   +4 more sources

Homologous recombination deficiency signatures in gastrointestinal and thoracic cancers correlate with platinum therapy duration

npj Precision Oncology, 2023
There is emerging evidence about the predictive role of homologous recombination deficiency (HRD), but this is less defined in gastrointestinal (GI) and thoracic malignancies. We reviewed whole genome (WGS) and transcriptomic (RNA-Seq) data from advanced
E. Tsang, V. Csizmok, L. Williamson, E. Pleasance, J. Topham, J. Karasinska, E. Titmuss, I. Schrader, S. Yip, B. Tessier-Cloutier, K. Mungall, T. Ng, Sophie Sun, H. Lim, J. Loree, J. Laskin, M. Marra, S. J. Jones, D. Schaeffer, D. Renouf   +19 more
semanticscholar   +1 more source