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Immunogenicity of a Heterologous Prime-Boost COVID-19 Vaccination with mRNA and Inactivated Virus Vaccines Compared with Homologous Vaccination Strategy against SARS-CoV-2 Variants [PDF]
Vaccines, 2022 Honglin Chen +2 more
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Shared sugars – parasite glycan homology in HIV-1 vaccine design
Trends in Parasitology, 2022Immune tolerance to self-glycans is a host mechanism to avoid autoimmunity, which is exploited by HIV-1 coating its envelope glycoproteins with glycans to evade neutralising antibodies (nAbs). Huettner et al. describe cross-reactivity between Schistosoma mansoni glycans and HIV-1 envelope glycoprotein glycans, suggesting a strategy for induction of HIV-
Lachlan P. Deimel, Quentin J. Sattentau
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Immunotherapy of tumors with vaccines based on xenogeneic homologous molecules
Anti-Cancer Drugs, 2002This review summarizes and discusses a new vaccine strategy based on xenogeneic homologous molecules by the breaking of immune tolerance against the growth factors or their receptors associated with tumor growth in a cross-reaction between the xenogeneic homologs and self-molecules. The xenogeneic vaccine may circumvent the fact that few tumor-specific
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Vaccine, 2009
Rotavirus-like particles (VLPs) have shown promise as rotavirus vaccine candidates in mice, rabbits and pigs. In pigs, VLP vaccines reduced rotavirus shedding and disease but only when used in conjunction with live attenuated human rotavirus. Using a porcine rotavirus pig model, rotavirus antigen shedding was reduced by up to 40% after vaccination with
El-Attar, Laila +6 more
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Rotavirus-like particles (VLPs) have shown promise as rotavirus vaccine candidates in mice, rabbits and pigs. In pigs, VLP vaccines reduced rotavirus shedding and disease but only when used in conjunction with live attenuated human rotavirus. Using a porcine rotavirus pig model, rotavirus antigen shedding was reduced by up to 40% after vaccination with
El-Attar, Laila +6 more
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Anaplasma marginale inactivated vaccine: dose titration against a homologous challenge
Comparative Immunology, Microbiology and Infectious Diseases, 2000The present study was performed to dose-titrate an Anaplasma marginale experimental immunogen derived from partially purified initial bodies from three geographically different Mexican strains. Three five-bovine groups were inoculated twice on days zero and 21 with A.
S D, Rodríguez +5 more
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Assessing the Reactogenicity of Homologous and Heterologous COVID-19 Vaccine Schedules
2023Introduction: COVID-19 vaccines were considered as the most effective mode to prevent morbidity and mortality from COVID-19. However, similar to other vaccines, adverse events post-vaccination is expected. This reactogenicity to vaccines varies by type of vaccine and vaccine dose and has primarily been studied in clinical trials with homologous dosing ...
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Journal of Infectious Diseases, 1977
An effective influenza virus vaccine should be capable of inducing protection against both the homologous strain of virus and the heterologous strains representing antigenic drift. For evaluation of the protection provided by an attenuated influenza virus vaccine, volunteers were immunized intranasally with either placebo or influenza A/England/42/72 ...
J D, Lee +3 more
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An effective influenza virus vaccine should be capable of inducing protection against both the homologous strain of virus and the heterologous strains representing antigenic drift. For evaluation of the protection provided by an attenuated influenza virus vaccine, volunteers were immunized intranasally with either placebo or influenza A/England/42/72 ...
J D, Lee +3 more
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Mycobacterial and monkeypox homologous epitopes: Building blocks of a robust monkeypox vaccine
Journal of BiosciencesNumerous scientific studies have established that the BCG vaccination reduces susceptibility to bacterial and viral infections, particularly those causing respiratory tract ailments. This effect is partly attributed to the crossreactivity of BCG antigens, which reinforces immunity and presents an important avenue for therapeutic interventions against ...
Shivank, Prajapati +7 more
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Biochemical and Biophysical Research Communications, 2008
alpha-Fetoprotein (AFP) is a diagnostic marker for the presence of hepatocellular carcinoma, and a potential target for immunotherapy. Unfortunately, the immunity to AFP is presumably difficult to elicit because of immune tolerance acquired during the development of immune system.
Wei, Zhang +12 more
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alpha-Fetoprotein (AFP) is a diagnostic marker for the presence of hepatocellular carcinoma, and a potential target for immunotherapy. Unfortunately, the immunity to AFP is presumably difficult to elicit because of immune tolerance acquired during the development of immune system.
Wei, Zhang +12 more
openaire +2 more sources