Results 241 to 250 of about 473,693 (291)

Musashi‐1 Drives Radioresistance and Stemness in Head and Neck Squamous Cell Carcinoma via a Radioresistant FaDu Model

Cancer Science, EarlyView.
Fractionated irradiation generated radioresistant F‐IRR cells with enhanced CSC properties despite slower proliferation. MSI1 was strongly upregulated and functionally promoted stemness, tumorigenicity, and radiation resistance. JNK signaling acted upstream of MSI1, while JNK inhibition suppressed these malignant traits, identifying the JNK–MSI1 axis ...
Na‐Eun Kang, Chan‐Woong Jung, Yun‐Ju Kim, Sung‐Gil Chi, Jeong‐Yub Kim, Myung‐Jin Park   +5 more
wiley   +1 more source

SLAMF6 Enhances the Efficacy of Anti‐PD‐L1 Immunotherapy in CRC Through the STAT1/CXCL10 Signaling Axis

Cancer Science, EarlyView.
SLAMF6 recruits SHP‐2 to activate STAT1, upregulates CXCL10 and PD‐L1, promotes CD8+T cell infiltration, and enhances the efficacy of anti‐PD‐L1 therapy. ABSTRACT As a T‐cell receptor co‐stimulatory protein, signaling lymphocyte activation molecule family 6 (SLAMF6) is a member of the immune cell activating receptor family and is expressed on T cells ...
Yu Wu, Xinhui Lv, Shunhao Zhang, Yafang Chen, Sicong Liu, Feiyang Song, Chunmei Zhao, Guihua Wang, Xudong Wang   +8 more
wiley   +1 more source

S‐Adenosylmethionine (SAM) hydrolases counter increased SAM epimerisation in thermophilic archaea

The FEBS Journal, EarlyView.
S‐Adenosyl‐l‐methionine (SAM) is a vital enzyme cofactor. Epimerisation at the sulfonium centre of biologically active (SS,SCα)‐SAM is driven by heat, yielding biologically inactive (RS,SCα)‐SAM. Here, two novel archaeal SAM hydrolases from the thermophilic Sulfolobus acidocaldarius and the halophilic Haloferax volcanii are shown to cleave (RS,SCα)‐SAM.
Agnes Bartels, Michael K. F. Mohr, Phillip Nußbaum, Marie Joest, Bianca Wassmer, Laurent Rasquin, Sonja‐Verena Albers, Jennifer N. Andexer   +7 more
wiley   +1 more source

Systemic immune profiling of heterologous versus homologous boosting of COVID-19 vaccination. [PDF]

J Transl Med
Han X, Jiang H, Zheng H, Jin P, Xu L, Wang F, Li S, Shao C, Jia S, Feng J, Xu M, Li J.   +11 more
europepmc   +1 more source

Transgenic selection and underlying mechanisms in apicomplexan parasites

The FEBS Journal, EarlyView.
Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju, Rakhee Lohia, Nishith Gupta   +2 more
wiley   +1 more source

Optimizing an avian influenza vaccine using a novel Bacterial Enzymatic Combinatorial Chemistry (BECC) TLR4 adjuvant. [PDF]

mSphere
Riley DV, Baracco L, Das S, Tenaglia BM, Speed S, Dillen C, Hayes J, Del Veliz S, Nijhuis H, Le Sage V, Despres HW, Coughlan L, Sun W, Frieman MB, Ernst RK.   +14 more
europepmc   +1 more source

Development and preliminary evaluation of a ΔtssB-EP as a live attenuated vaccine against Edwardsiella piscicida. [PDF]

Front Immunol
Das R, Xu C, Ghosh K, Barzkar N, Mukhopadhyay A, Evensen Ø.   +5 more
europepmc   +1 more source

Evaluation of Safety, Immunogenicity and Efficacy of an Inactivated Bovine Viral Diarrhea Virus (BVDV-1) Vaccine Candidate in Cattle. [PDF]

Viruses
Kalaiyarasu S, Mishra N, Sudhakar SB, Singh VP, Sanyal A.   +4 more
europepmc   +1 more source

Antibodies Cross-Reactive with Bundibugyo Virus in Ferrets Vaccinated with Ebola Virus Vaccine. [PDF]

Emerg Infect Dis
Wight J, Schulz H, Banadyga L.
europepmc   +1 more source

Genotype II Live-Attenuated ASFV Vaccine Bearing 24 Genes Deletion in 3 Independent Regions Is Able to Provide Complete Protection Against Homologous Lethal Challenge. [PDF]

FASEB J
Xu F, Dang W, Du Y, Li T, Liu H, Shi Z, Tian H, He J, Zheng H.   +8 more
europepmc   +1 more source