Results 1 to 10 of about 17,772 (214)

Cofactor engineering for improved production of 2,4-dihydroxybutyric acid via the synthetic homoserine pathway [PDF]

Frontiers in Bioengineering and Biotechnology
(L)-2,4-dihydroxybutyrate (DHB) is a versatile compound that can serve as a precursor for the synthesis of the methionine analog 2-hydroxy-4-(methylthio)butyrate and new advanced polymers.
Nadine Ihle, Laura Grüßner, Ceren Alkim, T. A. Stefanie Nguyen, Thomas Walther, Cláudio J. R. Frazão   +5 more
doaj   +2 more sources

Metabolic engineering strategies for L-Homoserine production in Escherichia coli [PDF]

Microbial Cell Factories
L-Homoserine, serves as a non-essential precursor for the essential amino acids derived from L-aspartate in both animals and humans. It finds widespread applications across the food, cosmetics, pharmaceutical, and animal feed industries.
Xin Jin, Sumeng Wang, Yanbing Wang, Qingsheng Qi, Quanfeng Liang   +4 more
doaj   +2 more sources

METABOLIC PATHWAYS OF HOMOSERINE IN THE MAMMAL [PDF]

Journal of Biological Chemistry, 1956
Y. Matsuo, Morton Rothstein, David M. Greenberg   +2 more
openalex   +3 more sources

Synthesis of N-Trityl-L-homoserine [PDF]

Chemischer Informationsdienst, 1982
AbstractDie Titelverbindung (II) kann auf 2 Wegen synthetisiert werden [(I)‐(II) (analoge Darstellung von N‐Trityl‐D,L‐homoserin) bzw. (III)‐(IV)‐(II)].
Kleomenis Barlos, Dimitrios Theodoropoulos   +1 more
openalex   +4 more sources

A pH-dependent direct sulfhydrylation pathway is required for the pathogenesis of Mycobacterium tuberculosis [PDF]

Communications Biology
Methionine is essential for the growth and survival of Mycobacterium tuberculosis (M. tuberculosis), however, the canonical transsulfuration pathway involved in the biosynthesis of methionine is dispensable, suggesting redundancy. This study explores the
Vaibhav Kumar Nain, Vishawjeet Barik, Manitosh Pandey, Mohit Pareek, Taruna Sharma, Rahul Pal, Shaifali Tyagi, Manish Bajpai, Prabhanjan Dwivedi, Bhishma Narayan Panda, Yashwant Kumar, Shailendra Asthana, Amit Kumar Pandey   +12 more
doaj   +2 more sources

Homoserine dehydrogenase of Serratia marcescens [PDF]

Biochemical Journal, 1972
M.S. Shailaja, M. R. Raghavendra Rao
openalex   +4 more sources

Toxic effect and inability of L-homoserine to be a nitrogen source for growth of Escherichia coli resolved by a combination of in vivo evolution engineering and omics analyses

Frontiers in Microbiology, 2022
L-homoserine is a pivotal intermediate in the carbon and nitrogen metabolism of E. coli. However, this non-canonical amino acid cannot be used as a nitrogen source for growth.
Ceren Alkim, Ceren Alkim, Daniele Farias, Julie Fredonnet, Helene Serrano-Bataille, Pauline Herviou, Marc Picot, Nawel Slama, Sebastien Dejean, Nicolas Morin, Brice Enjalbert, Jean M. François, Jean M. François   +12 more
doaj   +1 more source

Metabolic Transformation and Fermentation Condition of L-homoserine Synthesis by Corynebacterium glutamicum

Shipin gongye ke-ji, 2023
Objective: In this study, Corynebacterium glutamicum ATCC 13032 was used as the chassis cell for synthesizing L-homoserine and analyzing the effect of dissolved oxygen on product synthesis. Methods: First, the product tolerance of C.
Qiushuang GUO, Qianqian BAO, Yinbiao XU, Shuai CAI, Yang SUN, Hua LI, Yupeng LIU   +6 more
doaj   +1 more source

Effect of Homoserine on Growth of Mycobacterium smegmatis: Inhibition of Glutamate Transport by Homoserine [PDF]

Microbiology, 1987
Homoserine strongly inhibited growth of Mycobacterium smegmatis in medium containing glutamate as the sole source of nitrogen but was without effect when asparagine, alanine or glutamine was the sole nitrogen source. It was readily taken up by glutamate-grown cells, reaching an intracellular concentration of over 20 mM after 4 h incubation. The primary
Colin Ratledge, Venkataraman Sritharan, Paul R. Wheeler   +2 more
openaire   +3 more sources

Homoserine Esterification in Green Plants [PDF]

Plant Physiology, 1974
EXTRACTS OF PHYLOGENETICALLY DIVERSE PLANS WERE SURVEYED FOR THEIR ABILITY TO SYNTHESIZE THE FOLLOWING HOMOSERINE ESTERS WHICH ARE POTENTIAL PRECURSORS FOR METHIONINE AND THREONINE SYNTHESIS IN GREEN PLANTS: O-acetyl-, O-oxalyl-, O-succinyl-, O-malonyl-, and O-phosphohomoserine. Synthesis of O-acylhomoserine esters was detected only in Pisum sativum L.
Anne H. Datko, S. Harvey Mudd, John Giovanelli   +2 more
openaire   +3 more sources