Results 11 to 20 of about 35,612 (163)

DJ-1 interacts with and regulates paraoxonase-2, an enzyme critical for neuronal survival in response to oxidative stress. [PDF]

, 2014
Loss-of-function mutations in DJ-1 (PARK7) gene account for about 1% of all familial Parkinson's disease (PD). While its physiological function(s) are not completely clear, DJ-1 protects neurons against oxidative stress in both in vitro and in vivo ...
Aleyasin, Hossein, Bourquard, Noam, Callaghan, Steve, Figeys, Daniel, Huang, En, Irrcher, Isabella, Kim, Raymond H, Mak, Tak W, Park, David S, Parsanejad, Mohammad, Qu, Dianbo, Reddy, Srinivasa T, Rousseaux, Maxime WC, Slack, Ruth S, Vaillant, Dominique C, Zhang, Yi   +15 more
core   +6 more sources

Synthesis and analysis of stable isotope-labelled N-acyl homoserine lactones [PDF]

, 2016
Aliphatic aldehydes were deuterated at the alpha-position via a base-catalyzed exchange reaction with D2O. These deuterated building blocks were used for the synthesis of labelled analogues of quorum sensing signal molecules belonging to the three major ...
De Kimpe, Norbert, Mangelinckx, Sven, Ruysbergh, Ewout, Stevens, Christian   +3 more
core   +2 more sources

Gac two-component system in Pseudomonas syringae pv. tabaci is required for virulence but not for hypersensitive reaction [PDF]

, 2008
Pseudomonas syringae pv. tabaci 6605 causes wildfire disease on host tobacco plants. To investigate the regulatory mechanism of the expression of virulence, Gac two-Component system-defective mutants, Delta gacA and Delta gacS, and a double mutant, Delta
A Bultreys, A Chatterjee, A Schaefer, A Stintzi, B Quinones, B Quinones, C Fuqua, DK Willis, EO King, F Taguchi, F Taguchi, Fumiko Taguchi, J Yu, JW Costerton, Kazuhiro Toyoda, KH McClean, LM Keith, M Castaneda, M Elasri, M Marutani, MD Parkins, Md. Mijan Hossain, MF Alexeyev, Mizuri Marutani, NT Keen, PD Shaw, S Heeb, SL Lopez-Garcia, SM Kirov, ST Chancey, T Kitten, TG Kinscherf, TM Barta, Tomonori Shiraishi, WF Fett, Y Ishiga, Yoshishige Inagaki, Yujiro Ogawa, Yuki Ichinose   +38 more
core   +1 more source

Quorum-quenching activity of the AHL-lactonase from Bacillus licheniformis DAHB1 inhibits vibrio biofilm formation in vitro and reduces shrimp intestinal colonisation and mortality [PDF]

, 2014
Vibrio parahaemolyticus is a significant cause of gastroenteritis resulting from the consumption of undercooked sea foods and often cause significant infections in shrimp aquaculture. Vibrio virulence is associated with biofilm formation and is regulated
Shanthi, S., Spiers, A. J., Thomas, S., Vaseeharan, B., Vinoj, G.   +4 more
core   +3 more sources

Social interactions in the Burkholderia cepacia complex : biofilms and quorum sensing [PDF]

, 2010
Burkholderia cepacia complex bacteria are opportunistic pathogens that cause respiratory tract infections in susceptible patients, mainly people with cystic fibrosis. There is convincing evidence that B.
Coenye, Tom
core   +2 more sources

Synthesis and biological evaluation of novel N-α-haloacylated homoserine lactones as quorum sensing modulators [PDF]

, 2014
Novel N-α-haloacylated homoserine lactones, in which a halogen atom was introduced at the α-position of the carbonyl function of the N-acyl chain, have been studied as quorum sensing (QS) modulators and compared with a library of natural N-acylated ...
De Kimpe, Norbert, Mangelinckx, Sven, Ruysbergh, Ewout, Stevens, Christian, Syrpas, Michail   +4 more
core   +2 more sources

Priming winter wheat seeds with the bacterial quorum sensing signal N-hexanoyl-L-homoserine lactone (C6-HSL) shows potential to improve plant growth and seed yield [PDF]

, 2019
Several model plants are known to respond to bacterial quorum sensing molecules with altered root growth and gene expression patterns and induced resistance to plant pathogens.
Babenko, Lidia M., Foster, Jessica, Iungin, Olga S., Kosakivska, Iryna V., Moshynets, Olena V., Potters, Geert, Rogalsky, Sergiy P., Spiers, Andrew J.   +7 more
core   +2 more sources

Identification of QuiP, the Product of Gene PA1032, as the Second Acyl-Homoserine Lactone Acylase of Pseudomonas aeruginosa PAO1 [PDF]

, 2006
The relevance of the acyl homoserine lactone (acyl-HSL) quorum signals N-3-oxododecanoyl-homoserine lactone (3OC12HSL) and N-butanoyl-homoserine lactone to the biology and virulence of Pseudomonas aeruginosa is well investigated.
Huang, Jean J., Leadbetter, Jared R., Petersen, Ashley, Whiteley, Marvin   +3 more
core   +1 more source

Functional genomics with a comprehensive library of transposon mutants for the sulfate-reducing bacterium Desulfovibrio alaskensis G20. [PDF]

, 2014
UnlabelledThe genomes of sulfate-reducing bacteria remain poorly characterized, largely due to a paucity of experimental data and genetic tools. To meet this challenge, we generated an archived library of 15,477 mapped transposon insertion mutants in the
Arkin, Adam P, Davis, Ronald W, Deutschbauer, Adam, Esquivel, Zuelma, Hazen, Terry C, Kazakov, Alexey E, Kuehl, Jennifer V, Kuehn, Raquel, Nguyen, Michelle, Price, Morgan N, Ray, Jayashree, Wetmore, Kelly M   +11 more
core   +2 more sources

Effect of efflux pump inhibition on Pseudomonas aeruginosa transcriptome and virulence [PDF]

, 2017
Efflux pumps of the resistance-nodulation-cell-division (RND) family increase antibiotic resistance in many bacterial pathogens, representing candidate targets for the development of antibiotic adjuvants.
Baldelli, Valerio, Bondã¬, Roslen, Imperi, Francesco, Leoni, Livia, Longo, Francesca, Messina, Marco, Pillai, Cejoice Ramachandran, Rampioni, Giordano, Visca, Paolo   +8 more
core   +2 more sources