Results 61 to 70 of about 46,167 (302)

Identification of QuiP, the Product of Gene PA1032, as the Second Acyl-Homoserine Lactone Acylase of Pseudomonas aeruginosa PAO1 [PDF]

, 2006
The relevance of the acyl homoserine lactone (acyl-HSL) quorum signals N-3-oxododecanoyl-homoserine lactone (3OC12HSL) and N-butanoyl-homoserine lactone to the biology and virulence of Pseudomonas aeruginosa is well investigated.
Huang, Jean J., Leadbetter, Jared R., Petersen, Ashley, Whiteley, Marvin   +3 more
core   +1 more source

Structural determinants driving homoserine lactone ligand selection in the Pseudomonas aeruginosa LasR quorum-sensing receptor

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Pseudomonas aeruginosa uses quorum-sensing–mediated communication to coordinate group behaviors, including biofilm formation and virulence. Quorum sensing relies on extracellular signal molecules called autoinducers. In P.
Amelia R. McCready, J. Paczkowski, B. Henke, B. Bassler   +3 more
semanticscholar   +1 more source

Higher‐Level Structural Classification of Pseudomonas Cyclic Lipopeptides through Their Bioactive Conformation

Advanced Science, EarlyView.
Solution structures of a series of cyclic lipodepsipeptides from Pseudomonas reveal that these specialized metabolites adopt left‐handed alpha helical conformations of only two types, being either ‘stapled’ or ‘catch‐pole’ helix. The particular modular distribution of the biosynthetic gene clusters is found to determine the extent of their conserved ...
Benjámin Kovács, Durga Prasad, Vic De Roo, Matthias Vanheede, Penthip Muangkaew, Annemieke Madder, Monica Höfte, René De Mot, Niels Geudens, José C. Martins   +9 more
wiley   +1 more source

Quorum Sensing Activity of Enterobacter asburiae Isolated from Lettuce Leaves

Sensors, 2013
Bacterial communication or quorum sensing (QS) is achieved via sensing of QS signaling molecules consisting of oligopeptides in Gram-positive bacteria and N-acyl homoserine lactones (AHL) in most Gram-negative bacteria.
Kok-Gan Chan, Jian Woon Chen, Wai-Fong Yin, Yin Yin Lau, Joanita Sulaiman   +4 more
doaj   +1 more source

N-Acyl homoserine lactone analog modulators of the Pseudomonas aeruginosa RhlI quorum sensing signal synthase.

ACS Chemical Biology, 2019
Virulence in the Gram-negative pathogen Pseudomonas aeruginosa relies in part on the efficient functioning of two LuxI/R dependent quorum sensing (QS) cascades, namely the LasI/R and RhlI/R systems that generate and respond to N-(3-oxo)-dodecanoyl-L ...
Daniel Shin, Christoph Gorgulla, M. Boursier, Neilson R. Rexrode, E. Brown, H. Arthanari, H. Blackwell, R. Nagarajan   +7 more
semanticscholar   +1 more source

Mechanisms of Mitochondrial Toxicity and Cytotoxicity Caused by Pseudomonas aeruginosa Pyocyanin in Human Nasal Epithelial Cells

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Pseudomonas aeruginosa is an opportunistic pathogen in cystic fibrosis‐related chronic rhinosinusitis (CF‐CRS) that produces phenazine metabolites pyocyanin and 1‐hydroxyphenazine (1‐HP), which may have detrimental effects on mitochondria, reactive oxygen species (ROS), Ca2+ signaling, and apoptosis.
Joel C. Thompson, April Park, Yobouet Ines Kouakou, Zoey A. Miller, Nabil F. Darwich, Nithin D. Adappa, James N. Palmer, Ryan M. Carey, Robert J. Lee   +8 more
wiley   +1 more source

Tandem Mass Spectrometry Detection of Quorum Sensing Activity in Multidrug Resistant Clinical Isolate Acinetobacter baumannii

The Scientific World Journal, 2014
Many Proteobacteria communicate via production followed by response of quorum sensing molecules, namely, N-acyl homoserine lactones (AHLs). These molecules consist of a lactone moiety with N-acyl side chain with various chain lengths and degrees of ...
Kok-Gan Chan, Huey Jia Cheng, Jian Woon Chen, Wai-Fong Yin, Yun Fong Ngeow   +4 more
doaj   +1 more source

Joining the bacterial conversation: increasing the cultivation efficiency of soil bacteria with acyl-homoserine lactones and cAMP

Microbiology Spectrum, 2023
Bacteria need to be isolated in pure culture to gain access to the wide array of interesting functions they conceal. This is challenging because they do not live in isolation but instead in communities where they actively communicate and interact with ...
Marco A. Lopez Marin, Michal Strejcek, Ondrej Uhlik   +2 more
doaj   +1 more source

The dual transcriptional regulator CysR in Corynebacterium glutamicum ATCC 13032 controls a subset of genes of the McbR regulon in response to the availability of sulphide acceptor molecules [PDF]

, 2008
Background: Regulation of sulphur metabolism in Corynebacterium glutamicum ATCC 13032 has been studied intensively in the last few years, due to its industrial as well as scientific importance.
Albersmeier, Andreas, Kalinowski, Jörn, Koch, Daniel J., Milse, Johanna, Pühler, Alfred, Rückert, Christian   +5 more
core   +3 more sources

Chemical Methods for Peptide and Protein Backbone Cleavage

ChemistryEurope, EarlyView.
Protein cleavage plays essential roles in biology and is powerful for protein manipulation and functionalization as well as in recombinant expression and purification. Here, the historical background and most recent examples of chemical methods for protein and peptide backbone cleavage are discussed (part of the figure was generated in BioRender).
Miguel Angel Alena‐Rodriguez, Christian A. Olsen   +1 more
wiley   +1 more source