Results 61 to 70 of about 6,623 (164)

ANGPTL3 Inhibition with Evinacumab Results in Faster Clearance of IDL and LDL apoB in Patients with Homozygous Familial Hypercholesterolemia - Brief Report

, 2021
Objective: The mechanism by which evinacumab, a fully human monoclonal antibody directed against ANGPTL3 (angiopoietin-like 3 protein) lowers plasma LDL (low-density lipoprotein) cholesterol levels in patients with homozygous familial ...
van Harskamp, Dewi, Reeskamp, Laurens F., Gipe, Daniel A., Hovingh, G. Kees, Schierbeek, Henk, Dallinga-Thie, Geesje M., Millar, John S., Jansen, Hans, Wu, Liya, Rader, Daniel J., Cuchel, Marina   +10 more
core   +1 more source

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, Volume 183, Issue 9, Page 1779-1813, May 2026.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

Early‐onset familial hypercholesterolemia: A case of extensive xanthomas and premature coronary artery disease

Clinical Case Reports
Key Clinical Message Early recognition and management of familial hypercholesterolemia (FH) are crucial, especially in patients with extensive xanthomas and premature coronary artery disease.
Harsimran Kalsi, Ankur Singla, Sukhjot Kaur, Amogh Verma, Nathnael Abera Woldehana, Sarvesh Rustagi, Mahendra Pratap Singh   +6 more
doaj   +1 more source

Pregnancy in a Woman with Homozygous Familial Hypercholesterolemia Not on Low-Density Lipoprotein Apheresis

American Journal of Perinatology Reports, 2012
Pregnancy in women with homozygous familial hypercholesterolemia (FH) has been rarely reported and might pose risks on the mother and her fetus. Although most reported cases remained on low-density lipoprotein (LDL) apheresis, there are no clear ...
Akl C. Fahed, Anwar H. Nassar
doaj   +1 more source

Homozygous Familial Hypercholesterolemia: Anesthetic Challenges and Review of Literature

, 2017
Homozygous familial hypercholesterolemia (HoFH; Fredrickson IIa) is a rare autosomal dominant hereditary disease associated with increased low-density lipoprotein cholesterol.
Sudheer K Aarav, Neeti Makhija, Suruchi Ladha, Usha Kiran   +3 more
core   +1 more source

Brain Atrophy Associated With Risk Variant rs10191329 Extends Beyond Multiple Sclerosis

Annals of Neurology, Volume 99, Issue 4, Page 1083-1089, April 2026.
The risk allele rs10191329*A is associated with disease severity and brain atrophy in people with multiple sclerosis (MS). We investigated the association of rs10191329 with age‐related brain atrophy in a population‐based cohort using 10,308 magnetic resonance imaging (MRI) scans of 4,815 participants aged ≥ 45 years without MS in cross‐sectional and ...
Cato E. A. Corsten, Ana M. Marques, Elisabeth J. Vinke, C. Louk de Mol, Rinze F. Neuteboom, M. Kamran Ikram, Mohsen Ghanbari, Frank J. Wolters, Beatrijs Wokke, Meike W. Vernooij, Joost Smolders   +10 more
wiley   +1 more source

Xanthomas Regression in an 8-Year-Old Boy Treated With Lomitapide

JACC: Case Reports, 2019
This case reports on an 8-year-old boy with homozygous familial hypercholesterolemia with large tuberous xanthomas over his hands, elbows, buttocks, knees, and feet.
Genovefa Kolovou, MD, PhD, Aleksandros Tsoutsinos, MD, Irene Mastorakou, MD, MSc, PhD, Sophie Mavrogeni, MD, PhD, George Hatzigeorgiou, MD   +4 more
doaj   +1 more source

Phenotypical, Clinical, and Molecular Aspects of Adults and Children With Homozygous Familial Hypercholesterolemia in Iberoamerica [PDF]

, 2020
Objective: Characterize homozygous familial hypercholesterolemia (HoFH) individuals from Iberoamerica. Approach and Results: In a cross-sectional retrospective evaluation 134 individuals with a HoFH phenotype, 71 adults (age 39.3±15.8 years, 38.0% males),
Ceballos-Macias, José J, Mata, Pedro, Alonso, Rodrigo, Krieger, Jose E., Asenjo, Sylvia, Krieger, Jose E, Alves, Ana Catarina, Medeiros, Ana Margarida, Chacra, Ana Paula, Magaña-Torres, Maria T, Vasques-Cardenas, Norma A, Santos, Raul D, Bustos, Paula, Cuevas, Ada, Dell'Oca, Nicolás, Arrieta, Francisco, Bañares, Virginia G., Campo, Rafael, Morales, Álvaro J Ruiz, Corral, Pablo, Stoll, Mario, Bourbon, Mafalda, Jannes, Cinthia E., Metha, Roopa, Bañares, Virginia, Ressia, Andrés, Diaz-Diaz, José Luís, Araujo, Maria B., Arroyo, Raquel, Schreier, Laura, Ruiz Morales, Álvaro J, Reyes, Maria, Araujo, Maria B, Aguilar-Salinas, Carlos A, Merchan, Alonso, Jannes, Cinthia E, Vasques-Cardenas, Norma A.   +36 more
core   +1 more source

Engineering Lipid Nanoparticles for Precision RNA Delivery: Design Principles, Targeting Strategies, and Clinical Prospects

Cancer Nexus, Volume 2, Issue 2, April 2026.
ABSTRACT Lipid nanoparticles (LNPs) represent the most clinically advanced platform for RNA delivery and have enabled major breakthroughs in vaccines and gene therapies. However, their broader application is still limited by inefficient extrahepatic delivery, immunogenicity, and insufficient control over tissue‐ and cell‐specific targeting. This review
Yu Han, Ying Wang, Xintao Gao, Yan Lei, Yantao Li, Zhiyong Tang   +5 more
wiley   +1 more source

Utilidad de la ecografía de alta resolución en la valoración de la aterosclerosis preclínica, riesgo cardiovascular y diagnóstico de la hipercolesterolemia familiar [PDF]

, 2006
[spa] La presente tesis valora la utilidad de la ecografía carotídea de alta resolución, como técnica diagnóstica incruenta, útil, validada, reproducible y de bajo coste que nos permite:1.
Junyent Priu, Mireia
core