Results 61 to 70 of about 4,250,793 (306)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Journal of Quantitative Description: Digital MediaUtilizing an original data set of public Telegram channels affiliated with a right-wing extremist group, the Proud Boys, we conduct an exploratory analysis of the structure and nature of the group’s presence on the platform. Our study considers the group’
Wei Zhong +3 more
doaj +1 more source
Should \u3ci\u3eLucas v. South Carolina Coastal Council\u3c/i\u3e Protect Where the Wild Things Are? Of Beavers, Bob-o-Links, and Other Things that Go Bump in the Night [PDF]
, 2000 Lucas v. South Carolina Coastal Council is one of several recent Supreme Court decisions in which the Court used the Just Compensation Clause as a weapon of reaction to strike down an offending land use restriction.
Babcock, Hope M.
core +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Fundamental Hope and Practical Identity [PDF]
, 2017 This article considers the question ‘What makes hope rational?’ We take Adrienne Martin’s recent incorporation analysis of hope as representative of a tradition that views the rationality of hope as a matter of instrumental reasons.
Blöser, Claudia, Stahl, Titus
core +4 more sources
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Digital Inequality and Access by Low-Income Individuals to Public Benefits
Journal of Quantitative Description: Digital MediaThis study presents novel data on digital inequality to describe differences in individuals’ online interactions with public and private sector services.
Jihye Lee +4 more
doaj +1 more source
, 2009 This paper considers the Christian teacher’s “place” in today’s increasingly diverse public school classrooms. Specifically, the paper explores the complexities of working as a Christian within educational systems which promote tolerance of all cultures ...
Davids, Angie +4 more
core +1 more source
Fluconazole Monotherapy Is a Suboptimal Option for Initial Treatment of Cryptococcal Meningitis Because of Emergence of Resistance. [PDF]
, 2019 Cryptococcal meningitis is a lethal disease with few therapeutic options. Induction therapy with fluconazole has been consistently demonstrated to be associated with suboptimal microbiological and clinical outcomes. Exposure to fluconazole causes dynamic
Aller +31 more
core +1 more source