Results 111 to 120 of about 78,496,881 (308)
University Hospitals General Staff Meeting, April 30, 1931
, 1931 University of Minnesota. University of Minnesota Hospitals. (1931). University Hospitals General Staff Meeting, April 30, 1931.
University of Minnesota. University of Minnesota Hospitals
core
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
University Hospitals Staff Meeting Bulletin, October 5, 1933
, 1933 University of Minnesota. University of Minnesota Hospitals. (1933). University Hospitals Staff Meeting Bulletin, October 5, 1933.
University of Minnesota. University of Minnesota Hospitals
core
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
University Hospitals General Staff Meeting, April 7, 1932
, 1932 University of Minnesota. University of Minnesota Hospitals. (1932). University Hospitals General Staff Meeting, April 7, 1932.
University of Minnesota. University of Minnesota Hospitals
core
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
University Hospitals Staff Meeting Bulletin, April 12, 1934
, 1934 University of Minnesota. University of Minnesota Hospitals. (1934). University Hospitals Staff Meeting Bulletin, April 12, 1934.
University of Minnesota. University of Minnesota Hospitals
core
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
University Hospitals General Staff Meeting, December 3, 1931
, 1931 University of Minnesota. University of Minnesota Hospitals. (1931). University Hospitals General Staff Meeting, December 3, 1931.
University of Minnesota. University of Minnesota Hospitals
core
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source