Results 81 to 90 of about 78,496,881 (308)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Comparison of Physical Space of Pediatric Wards in Isfahan Hospitals with Standards

مدیریت اطلاعات سلامت, 2008
Introduction: Pediatric wards are places for care of children with physical and psychological problems. These places should be designed to reduce anxiety and Cather for children’s emotional and physical needs.
Mahmood Keyvanara, Leila Roholamin
doaj  

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Identification of learning needs of patients hospitalized at a University Hospital

Pakistan Journal of Medical Sciences, 2014
Objectives: This study was designed as a descriptive trial aimed at identifying learning needs of patients hospitalized at a university hospital and understanding whether these learning needs vary depending on certain patient characteristics.Methods: The study sample consisted of 1190 patients/caregivers hospitalized at all departments except for the ...
KAŞALİ, Kamber, ERKAN, H A, ÇELİK, S, POLAT, selda   +3 more
openaire   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Teaching evidence-based medicine in medical education: data on barriers and requirements in non-university and university hospitals

BMC Medical Education
Background Evidence-based medicine (EBM) is an essential component of medical practice, combining the best available scientific evidence with clinical expertise to support high-quality patient care.
Larissa Luchsinger, Anne Berthold, Monika Brodmann Maeder, Harald Mayer, Christoph Steinacker, Daniel von Langen, Michael Siegrist   +6 more
doaj   +1 more source

Characteristics of University Hospitals Implementing the Postgraduate Clinical Training “Tasukigake Method” and Their Correlation with Program Popularity: A Cross-Sectional Study

Advances in Medical Education and Practice, 2023
Sadatoshi Watanabe,1 Koshi Kataoka,2 Miwa Sekine,2 David Aune,2 Kiyoshi Shikino,3 Yuji Nishizaki1,2 1Clinical Translational Science, Juntendo University Graduate School of Medicine, Tokyo, Japan; 2Division of Medical Education, Juntendo University ...
Watanabe S, Kataoka K, Sekine M, Aune D, Shikino K, Nishizaki Y   +5 more
doaj  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Perfil clínico-epidemiológico de pacientes com doença de Chagas no Hospital Universitário de Maringá, Paraná, Brasil

Cadernos de Saúde Pública
Este trabalho descreveu o perfil clínico-epidemiológico de pacientes com doença de Chagas atendidos no ambulatório e na internação do Hospital Universitário de Maringá (HUM), Paraná, Brasil, entre maio de 1998 a maio de 2003.
Carlos Eduardo Bozelli, Silvana Marques de Araújo, Ana Lúcia Falavigna Guilherme, Mônica Lúcia Gomes   +3 more
doaj