Results 71 to 80 of about 11,515,911 (324)

Fast-growing intracellular Mycobacterium tuberculosis populations evade antibiotic treatment

Nature Communications
Slow growth rates are considered a hallmark of Mycobacterium tuberculosis (Mtb) and have been historically associated with persistence and subsequent drug tolerance.
Nathan J. Day, Baptiste Pradel, Chak Hon Luk, Pierre Santucci, Antony Fearns, Angela Rodgers, Beren Aylan, Laure Botella, Julien Vaubourgeix, Julio Ortiz Canseco, Natalia Athanasiadi, Maximiliano G. Gutierrez   +11 more
doaj   +1 more source

Artificial intelligence and neoantigens: paving the path for precision cancer immunotherapy

Frontiers in Immunology
Cancer immunotherapy has witnessed rapid advancement in recent years, with a particular focus on neoantigens as promising targets for personalized treatments.
Alla Bulashevska, Zsófia Nacsa, Franziska Lang, Markus Braun, Martin Machyna, Mustafa Diken, Liam Childs, Renate König   +7 more
doaj   +1 more source

Generation of three induced pluripotent cell lines (iPSCs) from an Aicardi–Goutières syndrome (AGS) patient harboring a deletion in the genomic locus of the sterile alpha motif and HD domain containing protein 1 (SAMHD1)

Stem Cell Research, 2020
Aicardi-Goutières syndrome (AGS) is a hereditary early onset encephalopathy. AGS patients display variable clinical manifestations including intracranial calcification, cerebral atrophy, white matter abnormalities and characteristic leukocytosis as well ...
Nina V. Fuchs, Maximilian Schieck, Michaela Neuenkirch, Christiane Tondera, Heike Schmitz, Lena Wendeburg, Doris Steinemann, Christiane Elpers, Frank Rutsch, Renate König   +9 more
doaj   +1 more source

Microbial source tracking of fecal contamination in Laguna Lake, Philippines using the library-dependent method, rep-PCR

Journal of Water and Health, 2021
Laguna Lake is an economically important resource in the Philippines, with reports of declining water quality due to fecal pollution. Currently, monitoring methods rely on counting fecal indicator bacteria, which does not supply information on potential ...
Laurice Beatrice Raphaelle O. dela Peña, Kevin L. Labrador, Mae Ashley G. Nacario, Nicole R. Bolo, Windell L. Rivera   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Host-Pathogen Interactions

, 2018
This detailed volume explores numerous multidisciplinary approaches employed to analyze the role of different molecules or strategies used by different guests to survive inside hosts.
López-Baena, Francisco Javier.editor.edthttp://id.loc.gov/vocabulary/relators/edt, Medina, Carlos.editor.edthttp://id.loc.gov/vocabulary/relators/edt, SpringerLink (Online service)   +2 more
core   +2 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Refining Host-Pathogen Interactions: Organ-on-Chip Side of the Coin

Pathogens, 2021
Bioinspired organ-level in vitro platforms that recapitulate human organ physiology and organ-specific responses have emerged as effective technologies for infectious disease research, drug discovery, and personalized medicine.
Buket Baddal, Pasquale Marrazzo
semanticscholar   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

The roles of GpsB and DivIVA in Staphylococcus aureus growth and division

Frontiers in Microbiology, 2023
The spheroid bacterium Staphylococcus aureus is often used as a model of morphogenesis due to its apparently simple cell cycle. S. aureus has many cell division proteins that are conserved across bacteria alluding to common functions.
Joshua A. F. Sutton, Joshua A. F. Sutton, Mark Cooke, Mariana Tinajero-Trejo, Mariana Tinajero-Trejo, Katarzyna Wacnik, Katarzyna Wacnik, Bartłomiej Salamaga, Bartłomiej Salamaga, Callum Portman-Ross, Callum Portman-Ross, Victoria A. Lund, Victoria A. Lund, Jamie K. Hobbs, Jamie K. Hobbs, Simon J. Foster, Simon J. Foster   +16 more
doaj   +1 more source