Results 111 to 120 of about 803,197 (352)

Modeling Host-Pathogen Interactions in the Context of the Microenvironment: Three-Dimensional Cell Culture Comes of Age

Infection and Immunity, 2018
Tissues and organs provide the structural and biochemical landscapes upon which microbial pathogens and commensals function to regulate health and disease. While flat two-dimensional (2-D) monolayers composed of a single cell type have provided important
Jennifer Barrila, A. Crabbé, Jiseon Yang, Karla Franco, Seth D. Nydam, Rebecca J. Forsyth, Richard R. Davis, Sandhya Gangaraju, C. M. Ott, C. Coyne, M. Bissell, C. Nickerson   +11 more
semanticscholar   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

A brief overview of mathematical modeling of the within-host dynamics of Mycobacterium tuberculosis

Frontiers in Applied Mathematics and Statistics
Tuberculosis (TB), a disease caused by bacteria Mycobacterium tuberculosis (Mtb), remains one of the major infectious diseases of humans with 10 million TB cases and 1.5 million deaths due to TB worldwide yearly.
Dipanjan Chakraborty, Saikat Batabyal, Vitaly V. Ganusov, Vitaly V. Ganusov   +3 more
doaj   +1 more source

Resolving host–pathogen interactions by dual RNA-seq

PLoS Pathogens, 2017
The transcriptome is a powerful proxy for the physiological state of a cell, healthy or diseased. As a result, transcriptome analysis has become a key tool in understanding the molecular changes that accompany bacterial infections of eukaryotic cells ...
A. Westermann, Lars Barquist, J. Vogel
semanticscholar   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

A primary human macrophage-enteroid co-culture model to investigate mucosal gut physiology and host-pathogen interactions

Scientific Reports, 2017
Integration of the intestinal epithelium and the mucosal immune system is critical for gut homeostasis. The intestinal epithelium is a functional barrier that secludes luminal content, senses changes in the gut microenvironment, and releases immune ...
Gaelle Noel, N. Baetz, J. Staab, M. Donowitz, O. Kovbasnjuk, M. Pasetti, N. Zachos   +6 more
semanticscholar   +1 more source

Persistent Leukoencephalopathy Following H1N1 Infection Associated With a Novel MYRF Variant (p.Gly735Asp)

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Mutations in myelin regulatory factor (MYRF) are linked to demyelinating disorders. We report a 38‐year‐old male who developed acute symmetric leukoencephalopathy mimicking a stroke following an influenza A virus infection. While clinical symptoms markedly improved with corticosteroids, MRI revealed persistent white matter lesions, contrasting
Jinghan Hu, Leiyun Huang, Wan Zhu, Min Peng, Qiang Gong, Jing Qian   +5 more
wiley   +1 more source

Genetic and phenotypic insights in the adaptation of Magnaporthe oryzae to rice. [PDF]

, 2015
Magnaporthe oryzae is the fungal pathogen causing rice blast. Rice resistance is commonly used to control this widely distributed and damaging disease of a major food crop.
Tharreau, Didier
core  

AMPK in Pathogens [PDF]

, 2016
During host–pathogen interactions, a complex web of events is crucial for the outcome of infection. Pathogen recognition triggers powerful cellular signaling events that is translated into the induction and maintenance of innate and adaptive host ...
A Acosta-Serrano, A Barquilla, A Barquilla, A Bonen, A Crawford, A Schubert-Unkmeir, A Singhal, A Street, A Woods, A Woods, AC Ferretti, AJ Hoogendijk, AK Pandey, AS Marsin, B Hurtrel, B Kelly, B Levine, B Sampaio-Marques, B Xiao, BF Holmes, BM Mony, BM Mony, C Bermejo, C Hutterer, C Polge, CB Ramsook, CE Moseley, CM Hull, CS Clemmens, CS Yang, CW Ong, CY Park, D Bumann, D Ghosh, D Kumar, D Miranda-Saavedra, D Moreira, D Sag, D Yang, DA Escobar, DE Levin, DF Egan, DG Hardie, DG Hardie, DM Shin, DW Park, E Gjini, E Rey-Jurado, E Vassella, EB Gordon, EJ Munoz-Elias, EM Al-Olayan, F Estruch, F Nagajyothi, F Navarro-Garcia, F Rousset, G Hu, G Lv, G Zandbergen van, G Zhou, GP Meares, H Huang, H Zangger, H Zhao, HC Ng, HC Ng, HJ Flint, HS Kwon, HS Zhang, HS Zhang, I Rabhi, I Tattoli, J Blagih, J Blagih, J Brunton, J Daniel, J Daniel, J Estaquier, J Estaquier, J Estaquier, J Kim, J Kim, J Mankouri, J McArdle, J McArdle, J Rolf, J Yang, J Yang, JC Ameisen, JD Artz, JD Burke, JD McKinney, JI MacRae, JJ Kim, JL Celenza, JL Celenza, JL Celenza, JM Brenchley, JM Gancedo, JM Yuk, JR Forbes, JV Li, JW Yu, JY Seo, K Ashrafi, K Barnes, K Hedbacker, K Inoki, K Moreau, K Nakashima, K Tsoyi, K Vickerman, K Yang, KL Buchanan, KL Caradonna, KM Jeong, KY Kang, KY Rhee, L Campillo-Gimenez, L Chantranupong, L Francione, LC Pollitt, LG Tilney, LJ Terry, M Carlson, M Cemma, M Fulco, M Parsons, M Raffatellu, M Romero-Gomez, MA Horwitz, MC Cumont, MC Lorenz, MI Hood, MR Gonzalez, MT Sorbara, N Kloft, NJ MacIver, O Vincent, P Sanz, R Appelberg, R Mehla, R Petter, R Petter, R Plummer, R Santarelli, R Tewari, RD Adam, RJ Shaw, S Chakrabarti, S Hohmann, S Horman, S Kuchin, S Pagans, S Steele, SA Hawley, SA Hawley, SB Kudchodkar, SC Stein, SE Reece, SH Kumar, SM Landfear, SR Waterman, T Naderer, TG Mitchell, TS Moser, TS Moser, V Bracchi, V Cecchinato, V Deretic, V Monceaux, W Lee, WT Ji, WW Winder, Y Abu Kwaik, Y Guo, Y Tang, Y Wang, YW Kim, Z Yang, Z Zhang, Z Zhao   +181 more
core   +4 more sources

Host‐Directed Biomaterials for Combatting Bloodstream Infections: From Macrocyclic Peptides to Immune‐Activating Cell Backpacks

Advanced Functional Materials, EarlyView.
Bloodstream infections (BSI) are one of the leading causes of mortality and morbidity in both civilian and military populations. This paper summarizes recent progress in novel treatment strategies to manage BSI arising from both bacterial and fungal pathogens using molecules, particles, and materials to elicit host‐directed immunity.
Thomas Thomou, Jagadish Krishnappa, Justin B. Schaal, Prasad Tongaonkar, Dat Q. Tran, Wenchao Gu, Yung‐Fu Chang, Michael E. Selsted, Shaoyi Jiang, Samir Mitragotri, Michael Super, Christopher J. Bettinger   +11 more
wiley   +1 more source