Results 111 to 120 of about 4,341,821 (307)

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

Type 1 interferons promote Staphylococcus aureus nasal colonization by inducing phagocyte apoptosis

Cell Death Discovery
Staphylococcus aureus is an important human commensal which persistently colonizes up to 30% of the human population, predominantly within the nasal cavity. The commensal lifestyle of S. aureus is complex, and the mechanisms underpinning colonization are
Emilio G. Vozza, Alanna M. Kelly, Clíodhna M. Daly, Sinead A. O’Rourke, Simon R. Carlile, Brenda Morris, Aisling Dunne, Rachel M. McLoughlin   +7 more
doaj   +1 more source

White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique
Amanda G. Sandoval Karamian, Tianjia Zhu, Hao Huang, Shavonne L. Massey, Mark P. Fitzgerald, Darshana Parikh, Arastoo Vossough, Ingo Helbig, Nicholas S. Abend   +8 more
wiley   +1 more source

Host-multi pathogen-warfare: Pathogen interactions in co-infected plants

, 2017
Studies of plant–pathogen interactions have historically focused on simple models of infection involving single host-single disease systems. However, plant infections often involve multiple species and/or genotypes and exhibit complexities not captured ...
Caroline Moffat (23311042), A. Abdullah (23424025), J. Hamblin (23460697), Mark Gibberd (23288299), Ayalsew Zerihun (23288296), Fran Lopez-Ruiz (23302018)   +5 more
core  

The Trw Type IV Secretion System of Bartonella Mediates Host-Specific Adhesion to Erythrocytes [PDF]

, 2010
Bacterial pathogens typically infect only a limited range of hosts; however, the genetic mechanisms governing host-specificity are poorly understood.
Danchin, Antoine, Philipp Engel, Dehio, Christoph, Quebatte, Maxime, Le Rhun, Danielle, Vayssier-Taussat Muriel, Maxime Quebatte, Saenz, Henri, Lionel Arnaud, Mavris, Arnaud Lionel, Lenaour Evelyne, Yang, Huanming, Sandra Cescau, Wang Jing, Mavris, Maria, Lenaour, Evelyne, Boulouis, Henri Jean, Taussat, Muriel, Antoine Danchin, Vayssier-Taussat, Muriel, Deng Hong Kuan, Jing Wang, Huanming Yang, Boulouis Henri Jean, Arnaud, Lionel, Quebatte Maxime, Engel, Philipp, Le Naour, Evelyne, Muriel Vayssier-Taussat, Henri Saenz, Maria Mavris, Dehio Christoph, Biville Francis, Danielle Le Rhun, Le Rhun Danielle, Danchin Antoine, Francis Biville, Christoph Dehio, Biville, Francis, Geneviève Marignac, Yang Huanming, Engel Philipp, Hong Kuan Deng, Cescau Sandra, Evelyne Lenaour, Mavris Maria, Deng, H.K., Deng, Hong Kuan, Wang, Jing, Marignac Geneviève, Cescau, Sandra, Marignac, Geneviève, Boulouis, Henri-Jean, Henri Jean Boulouis, Arnaud Lionel, Saenz Henri   +55 more
core   +1 more source

Dynamically Actuated Reconfigurable Topographical Surface Enables Active Control of Implant‐Associated Infections

Advanced Functional Materials, EarlyView.
A dynamically actuated reconfigurable topographical surface (DARTS) integrates contact‐mediated bactericidal nanotopography with programmable mechanical actuation to actively disrupt bacterial biofilms. Dynamic surface reconfiguration enhances bacterial killing and suppresses implant‐associated infections in vivo, providing a new strategy for active ...
Mohammad Asadi Tokmedash, Jihun Lee, J. Scott VanEpps, Sungmin Nam, Jouha Min   +4 more
wiley   +1 more source

An internal thioester in a pathogen surface protein mediates covalent host binding [PDF]

, 2015
This work was supported by the MRC, UK grant MR/K001485 for MW, JME, MR, MJB, USL; the BBSRC, UK grant BB/J00453 and the John Innes Foundation for MJB; the Wellcome Trust Institutional Strategic Support Fund 097831/Z/11/B for AMD; Wellcome Trust/JIF ...
Kan, Su-Yin, Dziewulska, Aleksandra Malgorzata, Rohde, Manfred, Schwarz-Linek, Ulrich, Miriam Weckener, Shirran, Sally Lorna, Bergmann, Rene, Jackson, Rosemary J, Su-Yin Kan, Edwards, John Michael, Miller, Ona K, Banfield, Mark J, Aleksandra M Dziewulska, Schwarz-Linek, Uli, Florence, Gordon John, Saalbach, Gerhard, Rosemary J Jackson, Ulrich Schwarz-Linek, Catherine H Botting, Gerhard Saalbach, Dziewulska, Aleksandra M, Walden, Miriam, Jackson, Rosemary J., Mark J Banfield, Gordon J Florence, John M Edwards, Botting, Catherine H, Manfred Rohde, Banfield, Mark J., Sally L Shirran, Florence, Gordon J, Rene Bergmann, Weckener, Miriam, Miller, Ona Kealoha, Ona K Miller, Shirran, Sally L, Botting, Catherine Helen, Edwards, John M, Miriam Walden   +38 more
core   +1 more source

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

Advanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou, Qiang Qin, Xiqin Li, Hanyu Ding, Chun Xu, Yan He, Qingsong Ye   +6 more
wiley   +1 more source

Drug resistant Mycobacterium tuberculosis strains have altered cell envelope hydrophobicity that influences infection outcomes in human macrophages

Scientific Reports
In recent decades, drug resistant (DR) strains of Mycobacterium tuberculosis (M.tb), the cause of tuberculosis (TB), have emerged that threaten public health.
Alyssa Schami, M. Nurul Islam, Matthew Wall, Amberlee Hicks, Reagan Meredith, Barry Kreiswirth, Barun Mathema, John T. Belisle, Jordi B. Torrelles   +8 more
doaj   +1 more source

Parallel Exploitation of Diverse Host Nutrients Enhances Salmonella Virulence [PDF]

, 2013
Pathogen access to host nutrients in infected tissues is fundamental for pathogen growth and virulence, disease progression, and infection control. However, our understanding of this crucial process is still rather limited because of experimental and ...
Burton, Neil A, Mazé, Alain, Beatrice Claudi (126116), Dirk Bumann (126124), Dirk Bumann, Schmidt Alexander, Burton Neil A., Farhan Hesso, Steeb Benjamin, Claudi Beatrice, Bumann Dirk, Alexander Schmidt, Hesso Farhan, Mazé Alain, Benjamin Steeb (148560), Tienz Petra, Neil A. Burton (407008), Beatrice Claudi, Alexander Schmidt (68515), Petra Tienz, Alain Mazé, Hesso Farhan (407009), Alain Mazé (126117), Neil A Burton, Claudi, Beatrice, Petra Tienz (291552), Tienz, Petra, Farhan, Hesso, Burton, Neil A., Bumann, Dirk, Benjamin Steeb, Steeb, Benjamin, Schmidt, Alexander   +32 more
core   +2 more sources