Results 201 to 210 of about 247,353 (310)

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source

Revealing Surface And Intracellular Membrane Morphologies of Host Pathogen Interactions Combining Chromatic Aberration Corrected SEM And STEM Imaging [PDF]

, 2010
Jens Greiser, Ingo Gestmann, Ma�rcia Attias, TC Paredes-Santos   +3 more
openalex   +1 more source

An integrative ultrastructural and transcriptomic analysis of host-pathogen interactions with human brain microvascular endothelial cells during cryptococcal infection: a preliminary study. [PDF]

Front Cell Infect Microbiol
Krishnan P, Udupi GA, Santhoshkumar R, M V M, H B VK, Netravathi, S N.   +6 more
europepmc   +1 more source

A Metal‐Free Carbon Monoxide Prodrug Suppresses Metastasis of Pancreatic and Breast Cancer

Advanced Science, EarlyView.
A metal‐free carbon monoxide (CO) prodrug, CO‐116, delivers controlled systemic CO without inhalation. CO suppresses the HRG1–heme axis, reducing intracellular heme availability. Attenuation of this pathway inhibits metastatic progression in pancreatic and triple‐negative breast cancer models.
Tiantian Zhang, Xiang Chen, Xiaoxiao Yang, Muskan Gori, Rohit Kumar Varshnaya, Dongning Liu, Cheryl Zhang, Michelle Yi Qin Chen, Zhengming Chen, George Zhang, Erika Patel, Qiyue Mao, Tan A. Ince, Chalet Tan, Binghe Wang, Yi‐Chieh Nancy Du   +15 more
wiley   +1 more source

A simple <i>ex vivo</i> bladder infection model permits study of host-pathogen interactions in urinary tract infection. [PDF]

FEMS Microbes
Köhn RM, Ramirez Finn L, Durand M, Costas A, Söderström B, Lacerda Mariano L, Ingersoll MA.   +6 more
europepmc   +1 more source

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source

Publisher Correction: Drug resistant Mycobacterium tuberculosis strains have altered cell envelope hydrophobicity that influences infection outcomes in human macrophages

Scientific Reports
Alyssa Schami, M. Nurul Islam, Matthew Wall, Amberlee Hicks, Reagan Meredith, Barry Kreiswirth, Barun Mathema, John T. Belisle, Jordi B. Torrelles   +8 more
doaj   +1 more source

High-throughput bioprinted 3D cultures for probing host-pathogen interactions in bioinspired microenvironments.

RSC Appl Polym
Graf J, Moore D, Grimes CL, Fromen CA, Kloxin AM.   +4 more
europepmc   +1 more source

Host-pathogen interactions involved in erythrocyte invasion by <i>Francisella tularensis</i>. [PDF]

Front Cell Infect Microbiol
Schreiber RM, D'Cunha L, Hall M, DeBastiani A, Schmitt DM, Cantlay S, Horzempa J.   +6 more
europepmc   +1 more source

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

Advanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang   +16 more
wiley   +1 more source