Results 211 to 220 of about 4,341,821 (307)

Vector competence across <i>Aedes aegypti</i> populations shaped by host-preference adaptation and host-pathogen interactions. [PDF]

J Virol
Castro-Rodríguez JA, Marín-Montesino JC, Mora-Herrera SI, Ruíz-Jiménez F, García-Knight MA.   +4 more
europepmc   +1 more source

LRG1 Drives Pathological Angiogenesis by Disrupting Neutrophil Mitochondrial Homeostasis in Bladder Cancer

Advanced Science, EarlyView.
In bladder cancer, LRG1 binds to ANXA2 to trigger mitochondrial ROS‐dependent NETosis. This pathogenic cascade actively uncouples endothelial‐mural cell interactions, driving profound vascular destabilization. Consequently, targeting the LRG1‐ANXA2 axis attenuates the neutrophil burden and induces structural vascular normalization, offering a powerful ...
Dongshan Chen, Cong Zhang, Song Xue, Yuan Zeng, Haochen Cui, Chenfei Wang, Jiayi Feng, Lei Yan, Yuanwei Zang   +8 more
wiley   +1 more source

Ranalexin-1G: A Promising Antimicrobial Peptide Targeting Virulence and Host-Pathogen Interactions in <i>Pseudomonas aeruginosa</i> In Vitro Models. [PDF]

Antibiotics (Basel)
Acunzo M, Zannella C, Giugliano R, Di Clemente L, Capasso C, Chianese A, Andriolo M, Donadio F, Esposito E, Monti A, Doti N, Fasciana TMA, Giammanco A, Galdiero M, Filippis A.   +14 more
europepmc   +1 more source

Subversion of Atypical Mucin Traps by a Spore‐Coat Effector Blocks Cellular Immunity in Drosophila

Advanced Science, EarlyView.
While the entomopathogenic fungus Metarhizium robertsii can evade insect humoral immunity, its subversion of cellular defenses is still elusive. We identify Eac1 as a spore‐coat protein essential for infecting drosophilids by targeting atypical mucins (Sgf1 and Sgf2), which can entrap spores in a gel matrix and thereby facilitate hemocyte encapsulation.
Shiqin Li, Haimin Chen, Gangqi Fang, Dongxiang Wei, Hongyun Wu, Chen Chen, Song Hong, Chengshu Wang   +7 more
wiley   +1 more source

Host-Pathogen Interactions in Cystic Fibrosis Lung Disease: Adaptation, Persistence, and Clinical Implications of <i>Pseudomonas aeruginosa</i>. [PDF]

Pathogens
Capraz Yavuz B.
europepmc   +1 more source

2,3,7,8-tetrachlorodibenzo-p-dioxin modifies the levels of p21 and TERT proteins during bovine Herpesvirus1 infection .

, 2010
DE MARTINO, LUISA, IOVANE, GIUSEPPE, GRANATO, GIOVANNA ELVIRA, FIORITO, FILOMENA, FLORIO, SALVATORE, Marfè G., CIARCIA, ROBERTO   +6 more
core  

QRICH1 Disrupts Endoplasmic Reticulum Homeostasis and Amplifies NF‐κB Signaling in Periodontal Ligament Stem Cells to Exacerbate Diabetic Periodontitis

Advanced Science, EarlyView.
QRICH1 has been established as a key factor contributing to impaired osteogenic potential and accelerated apoptosis of PDLSCs in diabetic periodontitis. QRICH1 not only significantly enhances UPR‐associated apoptotic signaling but also amplifies NF‐κB‐mediated inflammatory responses. Its inhibition restores osteogenic capacity and reduces alveolar bone
Han Li, Xiaoyu Yang, He Wang, Yunchun Kuang, Yiyao Hu, Houxuan Li, Shuhong Li, Deping Zeng, Jie Li, Jinlin Song   +9 more
wiley   +1 more source

Molecular investigation of tick-borne and zoonotic pathogen dissemination and host-pathogen interactions in canines. [PDF]

Sci Rep
Fatima A, Umer M, Rasool M, Yasmeen T, Muqaddas H, Nisa TU, Danish MF, Khalil MA, Alyami EM, Alghamdi OA, Elossaily GM, Tesemma M, Shahzadi W, Ullah S, Iqbal F.   +14 more
europepmc   +1 more source

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +1 more source

Profiling of human and microbial cell-free DNA reflects early host-pathogen interactions in sepsis. [PDF]

Front Immunol
Hoeter K, Neuberger EWI, Marriott L, De Falco A, Wiemann S, Schäfer MKE, Simon P, Kersaudy-Kerhoas M, Bodenstein M.   +8 more
europepmc   +1 more source