Results 251 to 260 of about 4,341,821 (307)

Chimeric IL‐6/4R‐LL37 Engineered Macrophages Achieve Synchronized Inflammation Control and Antimicrobial Defence in Sepsis

Advanced Science, EarlyView.
Engineered macrophages programmed in situ by LNP‐delivered IL‐6/4 fusion and LL37 mRNAs simultaneously dampen cytokine storm, promote M2‐like repair, and enhance direct bacterial killing in sepsis. This combinatorial strategy restores T cell and macrophage function, lowers organ bacterial burden, and improves survival, highlighting a precision, host ...
Tianyang Jie, Zheyu Zhang, Hao Zhang, Linke Bian, Penglong Zheng, Sijia Zhou, Minqi Wang, Mingyu Qu, Yufei Wang, Xinhua Qu, Bing Yue   +10 more
wiley   +1 more source

Establishment of a TRV-VIGS system in Coix (<i>Coix lacryma-jobi</i> L.) for functional study of host-pathogen interactions. [PDF]

Front Plant Sci
Zhao X, Wang G, He F, Li XD, Zhou C, Liu Q, Tan L, Weng Q.   +7 more
europepmc   +1 more source

Senkyunolide I Inhibits mtDNA‐cGAS‐STING Signaling in Macrophages via Targeting VDAC1 Oligomerization to Attenuate Ulcerative Colitis

Advanced Science, EarlyView.
In macrophages, senkyunolide I (SEI) directly targets the K12 residue of VDAC1 to inhibit its stress‐induced oligomerization, a critical upstream event that effectively prevents mitochondrial DNA release and subsequent cGAS‐STING pathway activation.
Zhiming Ye, Yihang Huang, Bohao Han, Lei Zhang, Can Yu, Yang Yang, Bing Liu, Yongping Jian, Zhixiang Xu, Cheng Zeng   +9 more
wiley   +1 more source

Immune Response and Gut Microbiota Shift in the Red Palm Weevil (Rhynchophorus ferrugineus) Infected With Entomopathogenic Fungus, Beauveria bassiana, Reveal Host-Pathogen Interactions. [PDF]

Arch Insect Biochem Physiol
Yang TH, Chang FM, Chen PC, Pudasaini R, Lu HP, Nai YS.   +5 more
europepmc   +1 more source

Design and Application of Nanozymes: Current Trends and Cutting‐Edge Breakthroughs

Advanced Science, EarlyView.
Kelong Fan, Hui Wei, Xiyun Yan
wiley   +1 more source

Extracellular CIRP Dysregulates Microglial Efferocytosis in Acute Ischemic Stroke via the TLR4/miR‐155/MafB Axis

Advanced Science, EarlyView.
eCIRP released in the stroke brain binds to TLR4 expressed on microglia to induce miR‐155, which suppresses MafB, decreases MerTK and downstream signaling to impair efferocytosis of apoptotic neurons, worsening the acute stroke outcomes. Inhibition of eCIRP‐TLR4 interaction with small peptide C23 attenuates eCIRP‐induced microglial efferocytic ...
Dmitriy Lapin, Dilara Aylar, Archna Sharma, Ping Wang   +3 more
wiley   +1 more source

<i>Neospora caninum</i>: Recent Progress in Host-Pathogen Interactions, Molecular Insights, and Control Strategies. [PDF]

Microorganisms
Debache K, Hemphill A.
europepmc   +1 more source

F‐Type Pyocin Versus Phage λ Tail: Conserved Hub, Divergent Fibers

Advanced Science, EarlyView.
Near‐atomic cryo‐EM structures of a Gram‐negative F‐type pyocin reveal a conserved tail tip architecture shared with bacteriophage λ together with a previously unrecognized side‐fiber attachment mode. These findings provide new insight into tailocin assembly and host recognition and establish a structural framework for engineering precision ...
Zhiwei Gu, Yufan Xie, Lanxin Wang, Luyan Ma, Xiaofei Ge, Jiawei Wang   +5 more
wiley   +1 more source

High-throughput bioprinted 3D cultures for probing host-pathogen interactions in bioinspired microenvironments.

RSC Appl Polym
Graf J, Moore D, Grimes CL, Fromen CA, Kloxin AM.   +4 more
europepmc   +1 more source

Dissecting placental host-pathogen interactions: Rift Valley fever virus infection in early human trophoblast stem cells. [PDF]

iScience
Gwon YD, Haider S, Knöfler M, Bradley M, Henriksson J, Evander M.   +5 more
europepmc   +1 more source