Results 251 to 260 of about 558,869 (280)

Improving host-directed therapy for tuberculous meningitis by linking clinical and multi-omics data

Tuberculosis, 2021
There is a clear need to improve host-directed therapy for tuberculous meningitis (TBM), the most severe and deadly manifestation of tuberculosis. Corticosteroids represent the only host-directed therapy of proven benefit in TBM, yet their effect is ...
Reinout Van Crevel, Julian Avila-Pacheco, Nguyen T T Thuong   +2 more
exaly   +2 more sources

Advancing host-directed therapy for tuberculosis

Nature Reviews Immunology, 2015
Improved treatments are needed for nearly all forms of Mycobacterium tuberculosis infection. Adjunctive host-directed therapies have the potential to shorten tuberculosis treatment duration, prevent resistance and reduce lung injury by promoting autophagy, antimicrobial peptide production and other macrophage effector mechanisms, as well as by ...
R. Wallis, R. Hafner
semanticscholar   +3 more sources

Host-directed Therapy: A New Arsenal to Come

Combinatorial Chemistry & High Throughput Screening, 2021
The emergence of drug-resistant strains among the variety of pathogens worsens the situation in today’s scenario. In such a situation, a very heavy demand for developing the new antibiotics has arisen, but unfortunately, very limited success has been achieved in this arena till now.
Mradul Mohan, Debapriya Bhattacharya
openaire   +2 more sources

Host-directed therapies for bacterial and viral infections [PDF]

Nature Reviews Drug Discovery, 2017
Despite the recent increase in the development of antivirals and antibiotics, antimicrobial resistance and the lack of broad-spectrum virus-targeting drugs are still important issues and additional alternative approaches to treat infectious diseases are urgently needed. Host-directed therapy (HDT) is an emerging approach in the field of anti-infectives.
Stefan H E Kaufmann, Anca Dorhoi, Richard S Hotchkiss   +2 more
exaly   +4 more sources

Host-directed drug therapy for tuberculosis

Nature Chemical Biology, 2015
Chemical compounds designed to enhance understanding of host-pathogen interaction together with next-generation 'smart drugs' will rationally drive the discovery of promising new host-directed targets against pathogens including Mycobacterium tuberculosis, the causative agent of tuberculosis.
Reto, Guler, Frank, Brombacher
openaire   +2 more sources

Host-Directed Therapies for Parasitic Diseases

Future Medicinal Chemistry, 2019
Parasitic infections are responsible for significant morbidity and mortality throughout the world. Management strategies rely primarily on antiparasitic drugs that have side effects and risk of drug resistance. Therefore, novel strategies are needed for treatment of parasitic infections.
Bhawana, Singh, Sanjay, Varikuti, Gregory, Halsey, Greta, Volpedo, Omar M, Hamza, Abhay R, Satoskar   +5 more
openaire   +2 more sources

Host-Directed Therapy with Inhalable Lovastatin Microspheres for Matrix Metalloproteinase Inhibition in Tuberculosis.

ACS Applied Bio Materials
Tuberculosis (TB) triggers a robust immune response, which leads to significant destruction of the lung tissue at the site of infection, aiding in the transmission of Mycobacterium tuberculosis (Mtb) to the hosts.
Agrim Jhilta, Krishna Jadhav, Rahul Sharma, Raghuraj Singh, Swarnima Negi, Neelesh Sharma, A. K. Singh, R. Verma   +7 more
semanticscholar   +1 more source

Bone morphogenetic protein 9 is a candidate prognostic biomarker and host-directed therapy target for sepsis

Science Translational Medicine
Defining next-generation immune therapeutics for the treatment of sepsis will involve biomarker-based therapeutic decision-making. Bone morphogenetic protein 9 (BMP9) is a cytokine in the transforming growth factor–β superfamily.
Haobo Bai, Q. Lu, C. Wu, Fang Xu, Jiayu Liu, Ke Wang, Hao Ding, Yibing Yin, Yi Liu, Xiaofei Lai, Ju Cao   +10 more
semanticscholar   +1 more source

Small Molecule Targeting PPM1A Activates Autophagy for Mycobacterium tuberculosis Host-Directed Therapy.

Journal of Medicinal Chemistry
Mycobacterium tuberculosis (Mtb), the infectious agent of tuberculosis (TB), causes over 1.5 million deaths globally every year. Host-directed therapies (HDT) for TB are desirable for their potential to shorten treatment and reduce the development of ...
Zhipeng Yu, Yile Liang, Stefania Berton, Liping Liu, Jiaqi Zou, Lu Chen, Zhongliang Xu, Cheng Luo, Jim Sun, Weibo Yang   +9 more
semanticscholar   +1 more source

Host-directed therapy of tuberculosis: what is in it for microRNA?

Expert Opinion on Therapeutic Targets, 2014
Tuberculosis (TB) is a major health threat and current intervention measures are far from satisfactory. MicroRNAs (miRs) have become major targets of investigations for different diseases due to their propensity to regulate gene expression in various biological processes.
IANNACCONE, MARCO, Dorhoi, Anca, Kaufmann, Stefan H. E.   +2 more
openaire   +5 more sources