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Opportunities and Challenges for Host-Directed Therapies in Tuberculosis
Current Pharmaceutical Design, 2016Tuberculosis (TB) ranks alongside the human immunodeficiency virus (HIV) as cause of death due to an infectious disease. Recently, host-targeted therapies (HDT) have gained attention as a means to shorten the course of treatment of drug-sensitive TB, improve treatment outcomes of drug-resistant TB and generally improve the efficacy and preserve or ...
Madhur, Sachan +5 more
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Host-Directed Therapies for Tuberculosis
Cold Spring Harbor Perspectives in MedicineHost-directed therapies (HDTs) to increase host control of Mycobacterium tuberculosis and limit the pathology caused by tuberculosis (TB) have advanced from the laboratory to the clinic. Several of these HDTs are repurposed drugs, which provide significant advantages over lengthy and costly traditional drug discovery approaches.
Stefan H, Oehlers +2 more
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Statins as Host-Directed Therapy for Tuberculosis
2020Statins are a class of drugs that inhibit HMG-CoA reductase, the rate-limiting step in cholesterol biosynthesis, and are commonly used for primary and secondary prevention of cardiovascular disease. In addition to lowering cholesterol, statins also have broad immunomodulatory properties, and their use has been associated with improved clinical outcomes
Noton K. Dutta, Petros C. Karakousis
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Host-Directed Therapy for AIDS
Annals of Internal Medicine, 1995R B, Stricker, B, Goldberg
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Host-directed therapy against tuberculosis: Concept and recent developments
Journal of Biosciences, 2023Sonakshi Udinia, M. Suar, Dhiraj Kumar
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Host-Directed Therapies for Tuberculosis.
Cold Spring Harbor perspectives in medicine, 2016Host-directed therapies are a relatively new and promising approach to treatment of tuberculosis. Modulation of specific host immune pathways, including those that impact inflammation and immunopathology, can limit mycobacterial infection and pathology, both in cell culture and in animal models.
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Host factors subverted by Mycobacterium tuberculosis: Potential targets for host directed therapy
International Reviews of Immunology, 2023Rashi Kalra +2 more
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Host-directed therapy in the treatment of Tuberculosis
2017As M. tuberculosis continues to exert itself as the leading cause of mortality attributed to an infectious disease, novel treatment strategies are urgently needed. Host-directed therapy (HDT) is an avenue by which the host immune response can be augmented to drive pathogen clearance and perhaps lessen the tissue damage associated with chronic infection.
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Host-Directed Therapy in Nontuberculous Mycobacterial Pulmonary Disease
Clinics in Chest Medicine, 2023Kenneth N Olivier
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