Results 81 to 90 of about 558,869 (280)

Deterministic and stochastic in-host tuberculosis models for bacterium-directed and host-directed therapy combination

Mathematical Medicine and Biology: A Journal of the IMA, 2022
AbstractMycobacterium tuberculosis (TB) infection can involve all immune system components and can result in different disease outcomes. The antibiotic TB drugs require strict adherence to prevent both disease relapse and mutation of drug- and multidrug-resistant strains.
openaire   +3 more sources

Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk

Nature, 2014
Tuberculosis remains second only to HIV/AIDS as the leading cause of mortality worldwide due to a single infectious agent. Despite chemotherapy, the global tuberculosis epidemic has intensified because of HIV co-infection, the lack of an effective ...
K. Mayer-Barber, B. Andrade, Sandra D. Oland, Eduardo P. Amaral, Daniel L. Barber, Jacqueline Gonzales, S. Derrick, Rui-ru Shi, N. P. Kumar, Wang Wei, Xing Yuan, Guolong Zhang, Ying Cai, S. Babu, M. Catálfamo, A. Salazar, L. Via, C. Barry, A. Sher   +18 more
semanticscholar   +1 more source

Investigation of a novel host-directed therapy for malaria through ENU mutagenesis [PDF]

, 2020
Treatments for malaria rapidly lose effectiveness due to parasite adaption. Using naturally occurring resistance to malaria as an example, it may be possible to circumvent this adaption by developing antimalarial therapies which render the host ...
Patrick Lelliott (12303566)
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Potentials of Host-Directed Therapies in Tuberculosis Management [PDF]

Journal of Clinical Medicine, 2019
Tuberculosis (TB) remains as a leading cause of mortality in developing countries, persisting as a major threat to the global public health. Current treatment involving a long antibiotic regimen brings concern to the topic of patient compliance, contributing to the emergence of drug resistant TB.
Yash Dara, Doron Volcani, Kush Shah, Kevin Shin, Vishwanath Venketaraman   +4 more
openaire   +2 more sources

Host-directed therapy for tuberculosis: Repurposed drugs toward global tuberculosis elimination

International Journal of Infectious Diseases
Despite the World Health Organization End TB Strategy, tuberculosis (TB) remains the world’s leading infectious cause of death. Conventional antimicrobial therapies are hindered by prolonged treatment durations, poor patient adherence, and drug toxicity.
Yi Hao Wong, Hai Tarng Chong, Ting Huey Hu, Catherine Wei Min Ong   +3 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

A Review and Meta-Analysis of Influenza Interactome Studies

Frontiers in Microbiology, 2022
Annually, the influenza virus causes 500,000 deaths worldwide. Influenza-associated mortality and morbidity is especially high among the elderly, children, and patients with chronic diseases.
Sonja Courtney Jun Hui Chua, Sonja Courtney Jun Hui Chua, Sonja Courtney Jun Hui Chua, Sonja Courtney Jun Hui Chua, Jianzhou Cui, Jianzhou Cui, Jianzhou Cui, David Engelberg, David Engelberg, David Engelberg, Lina Hsiu Kim Lim, Lina Hsiu Kim Lim, Lina Hsiu Kim Lim   +12 more
doaj   +1 more source