Results 61 to 70 of about 558,869 (280)

Combinatorial functions of two chimeric antibodies directed to human CD4 and one directed to the a-chain of the human interleukin-2 receptor [PDF]

, 1992
The general feasibility of chimerization of monoclonal antibodies (mAbs) has already been shown for a large number of them. In order to evaluate in vitro parameters relevant to immunosuppressive therapy, we have chimerized and synthesized two anti-CD4 ...
Schwirzke, Marina, Kaluzab, Brigitte, Reiter, Christian, Rieber, Ernst Peter, Scheuer, Werner, Flieger, Dimitri, Lenz, Helmut, Weissenhorn, Winfried, Weiss, Elisabeth H., Weidle, Ulrich H., Riethmüller, Gert   +10 more
core   +1 more source

Non-Steroidal Anti-inflammatory Drugs As Host-Directed Therapy for Tuberculosis: A Systematic Review [PDF]

, 2017
Lengthy, antimicrobial therapy targeting the pathogen is the mainstay of conventional tuberculosis treatment, complicated by emerging drug resistances. Host-directed therapies, including non-steroidal anti-inflammatory drugs (NSAIDs), in contrast, target
Kroesen, Vera M., Gröschel, Matthias I., Martinson, N, Martinson, Neil, Groschel, MI, van der Werf, TS, Zumla, A, Vera M. Kroesen, Vilaplana, Cristina, Kroesen, VM, Markus Maeurer, Cristina Vilaplana, Kroesen, Vera Marie, Zumla, Alimuddin, Matthias I. Gröschel, Vilaplana, C, Neil Martinson, van der Werf, Tjip S., Alimuddin Zumla, Universitat Autònoma de Barcelona, Maeurer, Markus, Tjip S. van der Werf, Maeurer, M   +22 more
core   +4 more sources

Host-mycobacteria conflict: Immune responses of the host vs. the mycobacteria TLR2 and TLR4 ligands and concomitant host-directed therapy.

Microbiology Research, 2022
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is one of the most grievous infectious diseases with long-term morbidity and unpredicted mortality rates globally.
K. Pattanaik, Srabasti Sengupta, B. Jit, Riddhi Kotak, A. Sonawane   +4 more
semanticscholar   +1 more source

Mycobacterium tuberculosis Infection-Driven Foamy Macrophages and Their Implications in Tuberculosis Control as Targets for Host-Directed Therapy

Frontiers in Immunology, 2020
Tuberculosis (TB) is a leading cause of death worldwide following infection with Mycobacterium tuberculosis (Mtb), with 1.5 million deaths from this disease reported in 2018.
Dahee Shim, Hagyu Kim, S. Shin
semanticscholar   +1 more source

Special Issue: From Host–Pathogen Interaction to Host-Directed Therapies [PDF]

Microorganisms, 2021
Despite the enormous progress made in the last few decades, infectious diseases still represent a huge challenge to human society and health systems, as evidenced by the recent SARS-CoV-2 pandemic [...]
Maria Salomé Gomes, Luisa Pereira
openaire   +3 more sources

Understanding Metabolic Regulation Between Host and Pathogens: New Opportunities for the Development of Improved Therapeutic Strategies Against Mycobacterium tuberculosis Infection

Frontiers in Cellular and Infection Microbiology, 2021
Mycobacterium tuberculosis (Mtb) causes chronic granulomatous lung disease in humans. Recently, novel strategies such as host-directed therapeutics and adjunctive therapies that enhance the effect of existing antibiotics have emerged to better control ...
Ji-Hae Park, Dahee Shim, Keu Eun San Kim, Wonsik Lee, Sung Jae Shin   +4 more
doaj   +1 more source

Performance of AAV8 vectors expressing human factor IX from a hepatic-selective promoter following intravenous injection into rats [PDF]

, 2008
Background: Vectors based on adeno-associated virus-8 (AAV8) have shown efficiency and efficacy for liver-directed gene therapy protocols following intravascular injection, particularly in relation to haemophilia gene therapy. AAV8 has also been proposed
Amit Nathwani, Baker, AH, Lorraine M Work, Tracey Graham, McIntosh, JB, Jenny McIntosh, Nathwani, A, Work, LM, Graham, T, McIntosh, J, Andrew H Baker   +10 more
core   +1 more source

Effects of host‐directed therapies on the pathology of tuberculosis [PDF]

The Journal of Pathology, 2020
AbstractMycobacterium tuberculosis, the causative agent of tuberculosis (TB), has co‐evolved with the human immune system and utilizes multiple strategies to persist within infected cells, to hijack several immune mechanisms, and to cause severe pathology and tissue damage in the host.
Liana Tsenova, Amit Singhal
openaire   +2 more sources

Targeting of myeloid-derived suppressor cells by all-trans retinoic acid as host-directed therapy for human tuberculosis

Cellular Immunology, 2021
Conventional anti-tuberculosis (TB) therapies comprise lengthy antibiotic treatment regimens, exacerbated by multi-drug resistant and extensively drug resistant mycobacterial strains.
Vinzeigh Leukes, A. Dorhoi, S. Malherbe, E. Maasdorp, J. Khoury, Shirley McAnda, G. Walzl, Nelita du Plessis   +7 more
semanticscholar   +1 more source

Morphoproteomic-Guided Host-Directed Therapy for Tuberculosis [PDF]

Frontiers in Immunology, 2017
In an effort to develop more effective therapy for tuberculosis (TB), research efforts are looking toward host-directed therapy, reprograming the body's natural defenses to better control the infection. While significant progress is being made, the efforts are limited by lack of understanding of the pathology and pathogenesis of adult type TB disease ...
Brown, Robert E., Hunter, Robert L., Hwang, Shen-An   +2 more
openaire   +2 more sources