Results 51 to 60 of about 4,368,636 (230)
Host-Directed Antivirals: A Realistic Alternative to Fight Zika Virus
Viruses, 2018 Zika virus (ZIKV), a mosquito-borne flavivirus, was an almost neglected pathogen until its introduction in the Americas in 2015, where it has been responsible for a threat to global health, causing a great social and sanitary alarm due to its increased ...
Juan-Carlos Saiz +4 more
doaj +1 more source
A Review and Meta-Analysis of Influenza Interactome Studies
Frontiers in Microbiology, 2022 Annually, the influenza virus causes 500,000 deaths worldwide. Influenza-associated mortality and morbidity is especially high among the elderly, children, and patients with chronic diseases.
Sonja Courtney Jun Hui Chua +12 more
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Development of Broad-Spectrum Antiviral Agents—Inspiration from Immunomodulatory Natural Products
Viruses, 2021 Developing broad-spectrum antiviral drugs remains an important issue as viral infections continue to threaten public health. Host-directed therapy is a method that focuses on potential targets in host cells or the body, instead of viral proteins.
Mengxun Zhang +5 more
doaj +1 more source
, 2004 OBJECTIVE: The purpose of this study was to validate an assessment tool used by occupational therapists to evaluate on-road driving performance. METHODS: The driving assessment was conducted over a 15-km route that consisted of a range of traffic ...
Wood, Joanne M. +3 more
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Anti-PD-1/PD-L1 therapy for infectious diseases: learning from the cancer paradigm
International Journal of Infectious Diseases, 2017 Objectives: Immune checkpoint pathways regulate optimal host immune responses against transformed cells, induce immunological memory, and limit tissue pathology.
Martin Rao +4 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Recent and New Strategies for Extensively Drug-resistant Tuberculosis
Mediterranean Journal of Infection, Microbes and Antimicrobials, 2018 Multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant TB (XDR-TB) are very problematic clinical conditions due to the few therapeutic options and long course of treatment.
Güneş Şenol
doaj +1 more source