Results 51 to 60 of about 558,869 (280)

Rapamycin modulates pulmonary pathology in a murine model of Mycobacterium tuberculosis infection

Disease Models & Mechanisms, 2021
Tuberculosis (TB) treatment regimens are lengthy, causing non-adherence to treatment. Inadequate treatment can lead to relapse and the development of drug resistance TB. Furthermore, patients often exhibit residual lung damage even after cure, increasing
Kamlesh Bhatt, Madhuri Bhagavathula, Sheetal Verma, Graham S. Timmins, Vojo P. Deretic, Jerrold J. Ellner, Padmini Salgame   +6 more
doaj   +1 more source

Inflammation and tuberculosis: host‐directed therapies [PDF]

Journal of Internal Medicine, 2014
AbstractTuberculosis (TB) is an airborne infectious disease that kills almost two million individuals every year. Multidrug‐resistant (MDR) TB is caused by strains of Mycobacterium tuberculosis (M. tb) resistant to isoniazid and rifampin, the backbone of first‐line antitubercular treatment.
A, Zumla, M, Rao, S K, Parida, S, Keshavjee, G, Cassell, R, Wallis, R, Axelsson-Robertsson, M, Doherty, J, Andersson, M, Maeurer   +9 more
openaire   +2 more sources

Towards host-directed therapies for tuberculosis [PDF]

Nature Reviews Drug Discovery, 2015
The treatment of tuberculosis is based on combinations of drugs that directly target Mycobacterium tuberculosis. A new global initiative is now focusing on a complementary approach of developing adjunct host-directed therapies.
Zumla, A., Chakaya, J., Hoelscher, M., Ntoumi, F., Rustomjee, R., Vilaplana, C., Yeboah-Manu, D., Rasolof, V., Munderi, P., Singh, N., Aklillu, E., Padayatchi, N., Macete, E., Kapata, N., Mulenga, M., Kibiki, G., Mfinanga, S., Nyirenda, T., Maboko, L., Garcia-Basteiro, A., Rakotosamimanana, N., Bates, M., Mwaba, P., Reither, K., Gagneux, S., Edwards, S., Mfinanga, E., Abdulla, S., Cardona, P. J., Russell, J. B., Gant, V., Noursadeghi, M., Elkington, P., Bonnet, M., Menendez, C., Dieye, T. N., Diarra, B., Maiga, A., Aseffa, A., Parida, S., Wejse, C., Petersen, E., Kaleebu, P., Oliver, M., Craig, G., Corrah, T., Tientcheu, L., Antonio, M., Rao, M., McHugh, T. D., Sheikh, A., Ippolito, G., Ramjee, G., Kaufmann, S. H., Churchyard, G., Steyn, A., Grobusch, M., Sanne, I., Martinson, N., Madansein, R., Wilkinson, R. J., Mayosi, B., Schito, M., Wallis, R. S., Maeurer, M.   +64 more
openaire   +7 more sources

Host-directed therapies in pulmonary tuberculosis: Updates on anti-inflammatory drugs

Frontiers in Medicine, 2022
Tuberculosis (TB) is a lethal disease and remains one of the top ten causes of mortality by an infectious disease worldwide. It can also result in significant morbidity related to persistent inflammation and tissue damage.
Juan M. Cubillos-Angulo, Juan M. Cubillos-Angulo, Juan M. Cubillos-Angulo, Betânia M. F. Nogueira, Betânia M. F. Nogueira, María B. Arriaga, María B. Arriaga, María B. Arriaga, Beatriz Barreto-Duarte, Beatriz Barreto-Duarte, Beatriz Barreto-Duarte, Beatriz Barreto-Duarte, Mariana Araújo-Pereira, Mariana Araújo-Pereira, Mariana Araújo-Pereira, Catarina D. Fernandes, Caian L. Vinhaes, Caian L. Vinhaes, Caian L. Vinhaes, Klauss Villalva-Serra, Klauss Villalva-Serra, Klauss Villalva-Serra, Klauss Villalva-Serra, Vanessa M. Nunes, João P. Miguez-Pinto, Eduardo P. Amaral, Bruno B. Andrade, Bruno B. Andrade, Bruno B. Andrade, Bruno B. Andrade, Bruno B. Andrade   +30 more
doaj   +1 more source

Ferritin: An Inflammatory Player Keeping Iron at the Core of Pathogen-Host Interactions

Microorganisms, 2020
Iron is an essential element for virtually all cell types due to its role in energy metabolism, nucleic acid synthesis and cell proliferation. Nevertheless, if free, iron induces cellular and organ damage through the formation of free radicals.
Ana C. Moreira, Gonçalo Mesquita, Maria Salomé Gomes   +2 more
doaj   +1 more source

Host-directed therapies for infectious diseases : current status, recent progress, and future prospects [PDF]

, 2016
Despite extensive global efforts in the fight against killer infectious diseases, they still cause one in four deaths worldwide and are important causes of long-term functional disability arising from tissue damage.
Rao, M., Rustomjee, R, Yeboah-Manu, Dorothy, Azhar, E., Rao, M,, Zumla, A, Kaufmann, Stefan H. E., Yeboah-Manu, D., Hoelscher, M., Vilaplana, Cris, Mwaba, P., Hoelscher, Michael, Wallis, RS, Mwaba, P, Chakaya, J, Kaufmann, SH, Host-Directed Therapies Network consortium,, Azhar, E, Ippolito, G, Maeurer, Markus, Wallis, Robert S., Zumla, A., Maeurer, M, Rao, Martin, Ippolito, Giuseppe, Hoelscher, M, Chakaya, Jeremiah, Rustomjee, Roxana, Chakaya, J., Ippolito, G., Rao, M, Zumla, Alimuddin, Kaufmann, SHE, Maeurer, M., Rustomjee, R., Vilaplana, C., Vilaplana, C, Kaufmann, S., Mwaba, Peter, Host-Directed Therapies Network consortium, Wallis, R., Azhar, Esam, Yeboah-Manu, D   +42 more
core   +1 more source

Efficacy of Adjunctive Tofacitinib Therapy in Mouse Models of Tuberculosis

EBioMedicine, 2015
The global tuberculosis (TB) epidemic and the spread of multi- and extensively-drug resistant strains of Mycobacterium tuberculosis (M.tb) have been fueled by low adherence to following lengthy treatment protocols, and the rapid spread of HIV (Human ...
Mamoudou Maiga, Bintou Ahmadou Ahidjo, Mariama C. Maiga, Laurene Cheung, Shaaretha Pelly, Shichun Lun, Flabou Bougoudogo, William R. Bishai   +7 more
doaj   +1 more source

Granulomas and Inflammation: Host-Directed Therapies for Tuberculosis [PDF]

Frontiers in Immunology, 2016
Tuberculosis (TB) remains a leading global health problem that is aggravated by emergence of drug-resistant strains, which account for increasing number of treatment-refractory cases. Thus, eradication of this disease will strongly require better therapeutic strategies.
Ndlovu, H, Marakalala, MJ
openaire   +4 more sources

Modulating Iron for Metabolic Support of TB Host Defense

Frontiers in Immunology, 2018
Tuberculosis (TB) is the world's biggest infectious disease killer. The increasing prevalence of multidrug-resistant and extensively drug-resistant TB demonstrates that current treatments are inadequate and there is an urgent need for novel therapies ...
James J. Phelan, Sharee A. Basdeo, Simone C. Tazoll, Sadhbh McGivern, Judit R. Saborido, Joseph Keane   +5 more
doaj   +1 more source

Physicochemical and Biological Evaluation of Curdlan-Poly(Lactic-Co-Glycolic Acid) Nanoparticles as a Host-Directed Therapy Against Mycobacterium Tuberculosis

Journal of Pharmacy and Science, 2021
Nanoparticles (NPs) that can activate macrophages infected with the tuberculosis causative pathogen Mycobacterium tuberculosis, could be an effective host directed therapy for the disease.
S. D'Souza, SM Du Plessis, S. Egieyeh, RB Bekale, Retsepile E Maphasa, AF Irabin, S. Sampson, A. Dube   +7 more
semanticscholar   +1 more source