Monocyte and Macrophage miRNA: Potent Biomarker and Target for Host-Directed Therapy for Tuberculosis. [PDF]
Front Immunol, 2021 The end TB strategy reinforces the essentiality of readily accessible biomarkers for early tuberculosis diagnosis. Exploration of microRNA (miRNA) and pathway analysis opens an avenue for the discovery of possible therapeutic targets.
Sampath P +3 more
europepmc +2 more sources
Neutrophil subsets enhance the efficacy of host-directed therapy in pneumococcal pneumonia. [PDF]
Mucosal ImmunologyHost-directed therapy, using nasal administration of the Toll-like receptor 5 agonist flagellin in combination with antibiotics, has proven effective against pneumococcal pneumonia.
Laura Matarazzo +13 more
semanticscholar +2 more sources
Mesenchymal Stromal Cells: an Antimicrobial and Host-Directed Therapy for Complex Infectious Diseases. [PDF]
Clin Microbiol Rev, 2021 There is an urgent need for new antimicrobial strategies for treating complex infections and emerging pathogens. Human mesenchymal stromal cells (MSCs) are adult multipotent cells with antimicrobial properties, mediated through direct bactericidal ...
Shaw TD +5 more
europepmc +2 more sources
The Manipulation of the Lipid Mediator Metabolism as Adjunct Host-Directed Therapy in Tuberculosis. [PDF]
Front Immunol, 2021 Host-directed therapies (HDTs) enhance the host response to tuberculosis (TB) infection to reduce disease severity. For instance, the manipulation of lipid mediator production diminishes the hyperactive immune response which is a known pathological ...
Nienaber A +4 more
europepmc +2 more sources
Repurposing diphenylbutylpiperidine-class antipsychotic drugs for host-directed therapy of Mycobacterium tuberculosis and Salmonella enterica infections. [PDF]
Sci Rep, 2021 The persistent increase of multidrug-resistant (MDR) Mycobacterium tuberculosis (Mtb) infections negatively impacts Tuberculosis treatment outcomes. Host-directed therapies (HDT) pose an complementing strategy, particularly since Mtb is highly successful
Heemskerk MT +13 more
europepmc +2 more sources
Host-directed therapies for multidrug resistant tuberculosis
International Journal of Mycobacteriology, 2016 Tuberculosis (TB) causes 1.3 million deaths annually. There are 0.5 million cases of multidrug resistant TB (MDR-TB) and the number of cases is rising globally.
Alimuddin Zumla, Markus Maeurer
doaj +4 more sources
Advancing host-directed therapy for tuberculosis: new therapeutic insights from the Toxoplasma gondii [PDF]
Microbial Cell, 2017 Tuberculosis (TB) drug-development strategies, a wide range of candidate host-directed therapies (HDT)s-including new and repurposed drugs, biologics, and cellular therapies-have been proposed to accelerate eradication of infection and overcome the ...
Chul-Su Yang
doaj +2 more sources
Heme Oxygenase-1 as a Pharmacological Target for Host-Directed Therapy to Limit Tuberculosis Associated Immunopathology [PDF]
Antioxidants, 2021 Excessive inflammation and tissue damage are pathological hallmarks of chronic pulmonary tuberculosis (TB). Despite decades of research, host regulation of these clinical consequences is poorly understood.
K. Chinta, H. Pacl, A. Agarwal, A. Steyn
semanticscholar +2 more sources
The Immune Mechanisms of Lung Parenchymal Damage in Tuberculosis and the Role of Host-Directed Therapy [PDF]
Frontiers in Microbiology, 2018 Impaired lung function is common in people with a history of tuberculosis. Host-directed therapy added to tuberculosis treatment may reduce lung damage and result in improved lung function.
C. Stek +5 more
semanticscholar +6 more sources
Natriuretic peptide-directed medical therapy: a systematic review [PDF]
Perioperative Medicine, 2020 Natriuretic peptides (NP) are strongly associated with perioperative cardiovascular events. However, in patients with raised NP, it remains unknown whether treatment to reduce NP levels prior to surgery results in better perioperative outcomes.
Christella S. Alphonsus +3 more
doaj +3 more sources