Host-directed therapy to combat mycobacterial infections. [PDF]
Immunol Rev, 2021 Upon infection, mycobacteria, such as Mycobacterium tuberculosis (Mtb) and nontuberculous mycobacteria (NTM), are recognized by host innate immune cells, triggering a series of intracellular processes that promote mycobacterial killing.
Kilinç G +3 more
europepmc +9 more sources
Host-directed therapy in diabetes and tuberculosis comorbidity toward global tuberculosis elimination [PDF]
International Journal of Infectious DiseasesHost-directed therapy could potentially revolutionize tuberculosis control as an adjunct to traditional antibiotics for the treatment of tuberculosis disease and as a strategy to prevent disease progression following Mycobacterium tuberculosis infection.
Steven G. Smith +2 more
doaj +6 more sources
Relevance of the Warburg Effect in Tuberculosis for Host-Directed Therapy [PDF]
Frontiers in Cellular and Infection Microbiology, 2020 Tuberculosis (TB) was responsible for more deaths in 2019 than any other infectious agent. This epidemic is exacerbated by the ongoing development of multi-drug resistance and HIV co-infection.
Bridgette M. Cumming +4 more
doaj +6 more sources
Host-Directed Therapy in Tuberculosis: Targeting Host Metabolism [PDF]
Frontiers in Immunology, 2020 Mycobacterium tuberculosis (Mtb) has complex and intricate interactions with host immune cells. Mtb can survive, persist, and grow within macrophages and thereby circumvent detection by the innate immune system.
Jae-Sung Kim +5 more
doaj +6 more sources
Repurposing Antifungals for Host-Directed Antiviral Therapy? [PDF]
Pharmaceuticals, 2022 Because of their epidemic and pandemic potential, emerging viruses are a major threat to global healthcare systems. While vaccination is in general a straightforward approach to prevent viral infections, immunization can also cause escape mutants that ...
Sebastian Schloer +2 more
doaj +4 more sources
Deep variational graph autoencoders for novel host-directed therapy options against COVID-19. [PDF]
Artif Intell Med, 2022 The COVID-19 pandemic has been keeping asking urgent questions with respect to therapeutic options. Existing drugs that can be repurposed promise rapid implementation in practice because of their prior approval.
Ray S +4 more
europepmc +4 more sources
Proposing Bromo-Epi-Androsterone for Host-Directed Therapy Against Tuberculosis [PDF]
PathogensBromoepiandrosterone (BEA), a synthetic analog of the adrenal steroid DHEA, holds promise as a host-directed therapy for both active and latent tuberculosis (TB).
Coad Thomas Dow, Liam Obaid
doaj +4 more sources
Host-Directed Therapy as a Novel Treatment Strategy to Overcome Tuberculosis: Targeting Immune Modulation [PDF]
Antibiotics, 2020 Tuberculosis (TB) is one of the leading causes of mortality and morbidity, particularly in developing countries, presenting a major threat to the public health. The currently recommended long term treatment regimen with multiple antibiotics is associated
Sultân Ahmed +2 more
exaly +3 more sources
Repurposing Saquinavir for Host-Directed Therapy to Control Mycobacterium Tuberculosis Infection [PDF]
Frontiers in Immunology, 2021 Despite the available antibiotics, tuberculosis (TB) has made its return since the 90’s of the last century as a global threat mostly due to co-infection with HIV, to the emergence of drug resistant strains and the lack of an effective vaccine.
David Pires +5 more
doaj +3 more sources
Natural products in anti-tuberculosis host-directed therapy
Biomedicine and PharmacotherapyGiven that the disease progression of tuberculosis (TB) is primarily related to the host's immune status, it has been gradually realized that chemotherapy that targets the bacteria may never, on its own, wholly eradicate Mycobacterium tuberculosis, the ...
Douglas B Lowrie +2 more
exaly +4 more sources