Results 21 to 30 of about 4,368,636 (230)

Rapamycin modulates pulmonary pathology in a murine model of Mycobacterium tuberculosis infection

Disease Models & Mechanisms, 2021
Tuberculosis (TB) treatment regimens are lengthy, causing non-adherence to treatment. Inadequate treatment can lead to relapse and the development of drug resistance TB. Furthermore, patients often exhibit residual lung damage even after cure, increasing
Kamlesh Bhatt, Madhuri Bhagavathula, Sheetal Verma, Graham S. Timmins, Vojo P. Deretic, Jerrold J. Ellner, Padmini Salgame   +6 more
doaj   +1 more source

Host-directed therapies in pulmonary tuberculosis: Updates on anti-inflammatory drugs

Frontiers in Medicine, 2022
Tuberculosis (TB) is a lethal disease and remains one of the top ten causes of mortality by an infectious disease worldwide. It can also result in significant morbidity related to persistent inflammation and tissue damage.
Juan M. Cubillos-Angulo, Juan M. Cubillos-Angulo, Juan M. Cubillos-Angulo, Betânia M. F. Nogueira, Betânia M. F. Nogueira, María B. Arriaga, María B. Arriaga, María B. Arriaga, Beatriz Barreto-Duarte, Beatriz Barreto-Duarte, Beatriz Barreto-Duarte, Beatriz Barreto-Duarte, Mariana Araújo-Pereira, Mariana Araújo-Pereira, Mariana Araújo-Pereira, Catarina D. Fernandes, Caian L. Vinhaes, Caian L. Vinhaes, Caian L. Vinhaes, Klauss Villalva-Serra, Klauss Villalva-Serra, Klauss Villalva-Serra, Klauss Villalva-Serra, Vanessa M. Nunes, João P. Miguez-Pinto, Eduardo P. Amaral, Bruno B. Andrade, Bruno B. Andrade, Bruno B. Andrade, Bruno B. Andrade, Bruno B. Andrade   +30 more
doaj   +1 more source

Self-Directed Learning [PDF]

, 2021
This book on self-directed learning (SDL) is devoted to original academic scholarship within the field of education, and is the 6th volume in the North-West University (NWU) SDL book series. In this book the authors explore how self-directed learning can
Mzuza, Maureen K., Bailey, Roxanne, du Toit-Brits, Charlene, Sebotsa, Tswakae, Kriek, Jeanne, Olivier, Jako, Fleisher, Steven C., Mahlaba, Sfiso C., Wirth, Karl R., Bergamin, Per, Dhakulkar, Amit, Nuhfer, Edward B., Dudu, Washington T., Jagals, Divan, Sebatana, Motlhale J., Watson, Rachel, Chahine, Iman C., Blignaut, Henry, de Beer, Josef   +18 more
core   +1 more source

Host Directed Therapy Against Infection by Boosting Innate Immunity

Frontiers in Immunology, 2020
The innate immune system constitutes the first line of defense against invading pathogens, regulating the normal microbiota and contributes to homeostasis. Today we have obtained detailed knowledge on receptors, signaling pathways, and effector molecules
Peter Bergman, Peter Bergman, Rubhana Raqib, Rokeya Sultana Rekha, Birgitta Agerberth, Gudmundur H. Gudmundsson, Gudmundur H. Gudmundsson   +6 more
doaj   +1 more source

Ferritin: An Inflammatory Player Keeping Iron at the Core of Pathogen-Host Interactions

Microorganisms, 2020
Iron is an essential element for virtually all cell types due to its role in energy metabolism, nucleic acid synthesis and cell proliferation. Nevertheless, if free, iron induces cellular and organ damage through the formation of free radicals.
Ana C. Moreira, Gonçalo Mesquita, Maria Salomé Gomes   +2 more
doaj   +1 more source

Efficacy of Adjunctive Tofacitinib Therapy in Mouse Models of Tuberculosis

EBioMedicine, 2015
The global tuberculosis (TB) epidemic and the spread of multi- and extensively-drug resistant strains of Mycobacterium tuberculosis (M.tb) have been fueled by low adherence to following lengthy treatment protocols, and the rapid spread of HIV (Human ...
Mamoudou Maiga, Bintou Ahmadou Ahidjo, Mariama C. Maiga, Laurene Cheung, Shaaretha Pelly, Shichun Lun, Flabou Bougoudogo, William R. Bishai   +7 more
doaj   +1 more source

Clinical review: Goal-directed therapy in high risk surgical patients [PDF]

, 2009
A small group of patients account for the majority of peri-operative morbidity and mortality. These 'high-risk' patients have a poor outcome due to their inability to meet the oxygen transport demands imposed on them by the nature of the surgical ...
Lees, N, Rhodes, A, Hamilton, M
core   +1 more source

Modulating Iron for Metabolic Support of TB Host Defense

Frontiers in Immunology, 2018
Tuberculosis (TB) is the world's biggest infectious disease killer. The increasing prevalence of multidrug-resistant and extensively drug-resistant TB demonstrates that current treatments are inadequate and there is an urgent need for novel therapies ...
James J. Phelan, Sharee A. Basdeo, Simone C. Tazoll, Sadhbh McGivern, Judit R. Saborido, Joseph Keane   +5 more
doaj   +1 more source

Natriuretic peptide-directed medical therapy: a systematic review

Perioperative Medicine, 2020
Natriuretic peptides (NP) are strongly associated with perioperative cardiovascular events. However, in patients with raised NP, it remains unknown whether treatment to reduce NP levels prior to surgery results in better perioperative outcomes.
Christella S. Alphonsus, Pooveshnie Govender, Reitze N. Rodseth, Bruce M. Biccard   +3 more
doaj   +1 more source

Host-directed therapies for multidrug resistant tuberculosis

International Journal of Mycobacteriology, 2016
Tuberculosis (TB) causes 1.3 million deaths annually. There are 0.5 million cases of multidrug resistant TB (MDR-TB) and the number of cases is rising globally.
Alimuddin Zumla, Markus Maeurer
doaj   +1 more source