Results 21 to 30 of about 558,869 (280)

Combination of MCL-1 and BCL-2 inhibitors is a promising approach for a host-directed therapy for tuberculosis. [PDF]

Biomed Pharmacother, 2023
Tuberculosis (TB) accounts for 1.6 million deaths annually and over 25% of deaths due to antimicrobial resistance. Mycobacterium tuberculosis (M.tb) drives MCL-1 expression (family member of anti-apoptotic BCL-2 proteins) to limit apoptosis and grow ...
Arnett E, Pahari S, Leopold Wager CM, Hernandez E, Bonifacio JR, Lumbreras M, Renshaw C, Montoya MJ, Opferman JT, Schlesinger LS.   +9 more
europepmc   +2 more sources

Host-Directed Therapy in Nontuberculous Mycobacterial Pulmonary Disease: Preclinical and Clinical Data Review. [PDF]

Clin Chest Med, 2023
Standard treatment of pulmonary nontuberculous mycobacteria (PNTM) infection involves a multi-drug antimicrobial regimen for at least 12 months. The length, complexity and side effect profile of antibiotic therapy for PNTM pose significant difficulties ...
Anidi IU, Olivier KN.
europepmc   +2 more sources

Advances in host-directed therapy for tuberculosis and HIV coinfection: enhancing immune responses. [PDF]

Trends Microbiol
Tuberculosis (TB) and HIV coinfection present a significant global health challenge worldwide. While most individuals infected with Mycobacterium tuberculosis (Mtb) have clinically asymptomatic latent TB infection (LTBI), those with immunosuppressive ...
Prasanna P, Herrera B, Schlesinger LS, Paiardini M, Sharan R.   +4 more
europepmc   +2 more sources

Doxycycline host-directed therapy in human pulmonary tuberculosis. [PDF]

J Clin Invest, 2021
BACKGROUND Matrix metalloproteinases (MMPs) are implicated as key regulators of tissue destruction in tuberculosis (TB) and may be a target for host-directed therapy.
Miow QH, Vallejo AF, Wang Y, Hong JM, Bai C, Teo FS, Wang AD, Loh HR, Tan TZ, Ding Y, She HW, Gan SH, Paton NI, Lum J, Tay A, Chee CB, Tambyah PA, Polak ME, Wang YT, Singhal A, Elkington PT, Friedland JS, Ong CW.   +22 more
europepmc   +2 more sources

Host-Directed Therapies for Tuberculosis [PDF]

Pathogens, 2022
Tuberculosis (TB) is one of the leading causes of death worldwide, consistently threatening public health. Conventional tuberculosis treatment requires a long-term treatment regimen and is associated with side effects.
Jung, Yu-Jin, Hyo-Ji Lee, Eui-Kwon Jeong, Jeong, Eui-Kwon, Lee, Hyo-Ji, Yu-Jin Jung   +5 more
core   +4 more sources

LncRNA: A Potential Target for Host-Directed Therapy of Candida Infection. [PDF]

Pharmaceutics, 2022
Despite various drugs work against Candida, candidiasis represents clinical management challenges worldwide due to the rising incidence and recurrence rate, as well as epidemics, of new drug-resistant pathogens.
Wang Y, Xu H, Chen N, Yang J, Zhou H.
europepmc   +2 more sources

Tuberculosis endotypes to guide stratified host-directed therapy. [PDF]

Med, 2021
There is hope that host-directed therapy (HDT) for Tuberculosis (TB) can either shorten treatment duration, help cure drug resistant disease or limit the immunopathology. Many candidate HDT drugs have been proposed, however solid evidence only exists for
DiNardo AR, Nishiguchi T, Grimm SL, Schlesinger LS, Graviss EA, Cirillo JD, Coarfa C, Mandalakas AM, Heyckendorf J, Kaufmann SHE, Lange C, Netea MG, Van Crevel R.   +12 more
europepmc   +2 more sources

The antidepressant sertraline provides a novel host directed therapy module for augmenting TB therapy [PDF]

eLife, 2023
A prolonged therapy, primarily responsible for development of drug resistance by Mycobacterium tuberculosis (Mtb), obligates any new TB regimen to not only reduce treatment duration but also escape pathogen resistance mechanisms.
Deepthi Shankaran, Anjali Singh, Stanzin Dawa, Prabhakar Arumugam, Sheetal Gandotra, Vivek Rao   +5 more
doaj   +2 more sources

Host-directed therapy with amiodarone in preclinical models restricts mycobacterial infection and enhances autophagy. [PDF]

Microbiol Spectr
Mycobacterium tuberculosis (Mtb) as well as nontuberculous mycobacteria are intracellular pathogens whose treatment is extensive and increasingly impaired due to the rise of mycobacterial drug resistance.
Kilinç G, Boland R, Heemskerk MT, Spaink HP, Haks MC, van der Vaart M, Ottenhoff THM, Meijer AH, Saris A.   +8 more
europepmc   +2 more sources

Host-directed therapies for tuberculous pericarditis [PDF]

International Journal of Infectious Diseases, 2015
TB Pericarditis is associated with significant inflammatory and immune responses which can paradoxically cause injury to the pericardium and myocardium. Management with anti-TB therapy alone does not prevent complications or reduce mortality.
Moll, G,, Zumla, A, Alimuddin Zumla, Maeurer, Markus, Markus Maeurer, Moll, Guido, Mayosi, Bongani M., Guido Moll, Bongani M. Mayosi, Zumla, Alimuddin, Maeurer, M,, Mayosi, BM   +11 more
core   +5 more sources