Results 71 to 80 of about 674,293 (317)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Lack of phenotypic and evolutionary cross-resistance against parasitoids and pathogens in Drosophila melanogaster

, 2012
BackgroundWhen organisms are attacked by multiple natural enemies, the evolution of a resistance mechanism to one natural enemy will be influenced by the degree of cross-resistance to another natural enemy.
Futerman Peter H., Sophie J Layen, H Charles J Godfray, Godfray, Charles, Kraaijeveld Alex R., Layen, Sophie, Alex R. Kraaijeveld*¤a, Sophie J. Layen, Futerman, Peter, Godfray H. Charles J., Peter H Futerman, H. Charles, Kraaijeveld, Alex R., Peter H. Futerman, Alex R Kraaijeveld, Layen Sophie J.   +15 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Effects of Different Shelling Methods on Data Variability during Field Screening for Reduced Aflatoxin Contamination in Maize

Toxins
Non-genetic variation limits the identification of novel maize germplasm with genetic markers for reduced Aspergillus flavus infection and aflatoxin contamination.
Alison Adams, Daniel Jeffers, Shien Lu, Baozhu Guo, W. Paul Williams, Jake C. Fountain   +5 more
doaj   +1 more source

The Enterococcus Cassette Chromosome, a Genomic Variation Enabler in Enterococci

mSphere, 2018
Enterococcus faecium has a highly variable genome prone to recombination and horizontal gene transfer. Here, we have identified a novel genetic island with an insertion locus and mobilization genes similar to those of staphylococcus cassette chromosome ...
A. Sivertsen, J. Janice, T. Pedersen, T. M. Wagner, J. Hegstad, K. Hegstad   +5 more
doaj   +1 more source

Host Resistance in Sepsis and Trauma

Annals of Surgery, 1975
Host resistance to infection was measured by the in vivo response to 5 delayed hypersensitivity antigens and to sensitivity and challenge by dinitrochlorobenzene (DNCB) in 55 seriously ill or injured patients and in 50 preoperative patients. A close correlation between infections, septicemia, death related to infection and anergy was found in the ...
L D, MacLean, J L, Meakins, K, Taguchi, J P, Duignan, K S, Dhillon, J, Gordon   +5 more
openaire   +3 more sources

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Altering host resistance to infections through microbial transplantation

, 2011
Host resistance to bacterial infections is thought to be dictated by host genetic factors. Infections by the natural murine enteric pathogen Citrobacter rodentium (used as a model of human enteropathogenic and enterohaemorrhagic E.
Vacharaksa, Anjalee, Finlay, B. Brett, Thanachayanont, Teerawat, Croxen, Matthew, Willing, Benjamin P.   +4 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The role of effectors in nonhost resistance to filamentous plant pathogens [PDF]

, 2014
In nature, most plants are resistant to a wide range of phytopathogens. However, mechanisms contributing to this so-called nonhost resistance (NHR) are poorly understood.
McLellan, Hazel, Remco eStam, Gaëtan eThilliez, Remco Stam, Thilliez, Gaëtan, Gaëtan Thilliez, Sophie Mantelin, Hazel eMcLellan, Hazel McLellan, Stam, Remco, Mantelin, Sophie, Sophie eMantelin   +11 more
core   +1 more source