Results 81 to 90 of about 1,451,495 (316)
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Role of the microbiome in human development. [PDF]
, 2019 The host-microbiome supraorganism appears to have coevolved and the unperturbed microbial component of the dyad renders host health sustainable. This coevolution has likely shaped evolving phenotypes in all life forms on this predominantly microbial ...
Blaser, Martin J +3 more
core
Host-pathogen evolutionary signatures reveal dynamics and future invasions of vampire bat rabies [PDF]
, 2016 Anticipating how epidemics will spread across landscapes requires understanding host dispersal events that are notoriously difficult to measure. Here, we contrast host and virus genetic signatures to resolve the spatiotemporal dynamics underlying ...
Alice Broos +14 more
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Modeling the impact of host resistance on structured tick population dynamics
Mathematics in Applied Sciences and Engineering, 2020 For a variety of tick species, the resistance, behavioural and immunological response of hosts has been reported in the biological literature but its impact on tick population dynamics has not been mathematically formulated and analyzed using dynamical ...
Mahnaz Alavinejad +2 more
doaj +1 more source
Genomic comparison of diverse Salmonella serovars isolated from swine. [PDF]
, 2019 Food animals act as a reservoir for many foodborne pathogens. Salmonella enterica is one of the leading pathogens that cause food borne illness in a broad host range including animals and humans.
Barrett, John B +9 more
core +2 more sources
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
World malaria report 2025: Growing biological threats, shrinking resources
Decoding Infection and TransmissionThe World Malaria Report 2025 documents operational progress while exposing systemic vulnerabilities that could reverse two decades of gains. Several biological threats are converging in Sub-Saharan Africa: artemisinin partial resistance, parasites ...
Lucien Platon, Feng Lu, Didier Ménard
doaj +1 more source
Exploring the utility of Brachypodium distachyon as a model pathosystem for the wheat pathogen Zymoseptoria tritici [PDF]
, 2015 peer-reviewedBackground Zymoseptoria tritici, the causative organism of Septoria tritici blotch disease is a prevalent biotic stressor of wheat production, exerting substantial economic constraints on farmers, requiring ...
Doohan, Fiona +2 more
core +1 more source