Results 91 to 100 of about 674,293 (317)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Differential gene expression in nearly isogenic lines with QTL for partial resistance to Puccinia hordei in barley [PDF]

, 2010
Background The barley-Puccinia hordei (barley leaf rust) pathosystem is a model for investigating partial disease resistance in crop plants and genetic mapping of phenotypic resistance has identified several quantitative trait loci (QTL) for partial ...
Hedley Peter E, Vels, S.A., Thierry C Marcel, Chen, Xinwei, Chen, X., Rients E Niks, Niks, Rients, Hedley, Peter, Hedley, Peter E., Druka, Arnis, Hedley, P.E., Marcel, Thierry C., Marcel, Thierry, T., Vels, Anton, Peter E Hedley, Anton Vels, Druka Arnis, Marcel, T.C., Arnis Druka, Morris Jenny, Morris, J., Waugh, R., Marcel, Thierry, Xinwei Chen, Vels Anton, Niks, R.E., Robbie Waugh, Chen Xinwei, Druka, A., Waugh, Robbie, Waugh Robbie, Niks Rients E, Jenny Morris, Niks, Rients E., Marcel Thierry C, Waugh, Robbie; id_orcid, Morris, Jenny   +36 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Recessive Resistance to Plant Viruses: Potential Resistance Genes Beyond Translation Initiation Factors

Frontiers in Microbiology, 2016
The ability of plant viruses to propagate their genomes in host cells depends on many host factors. In the absence of an agrochemical that specifically targets plant viral infection cycles, one of the most effective methods for controlling viral diseases
Masayoshi Hashimoto, Yutaro Neriya, Yasuyuki Yamaji, Shigetou Namba   +3 more
doaj   +1 more source

No better time to FRET: shedding light on host pathogen interactions [PDF]

, 2010
Understanding the spatio-temporal subversion of host cell signaling by bacterial virulence factors is key to combating infectious diseases. Following a recent study by Buntru and co-workers published in BMC Biology, we review how fluorescence (Forster ...
Leong, J.M., Goguen, J.D., Goguen, JD, Leong, JM, Hayward, RD, Hayward, Richard D.   +5 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

The lectin receptor kinase LecRK-I.9 is a novel Phytophthora resistance component and a potential host target for a RXLR effector

, 2011
In plants, an active defense against biotrophic pathogens is dependent on a functional continuum between the cell wall (CW) and the plasma membrane (PM). It is thus anticipated that proteins maintaining this continuum also function in defense. The legume-
Sofieke Klamer, Govers Francine, Weide, R., Mara de Sain, Rob Weide, Anne Gouget, Canut Herve, Govers, F., de Sain Mara, Weide Rob, Gouget, A., Herve Canut, Francine Govers, de Sain, M., Bouwmeester Klaas, Canut, H., Klaas Bouwmeester, Gouget Anne, Sain, M., de, Klamer, S., Bouwmeester, K., Klamer Sofieke   +21 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Evolution of linked avirulence effectors in Leptosphaeria maculans is affected by genomic environment and exposure to resistance genes in host plants

, 2010
Brassica napus (canola) cultivars and isolates of the blackleg fungus, Leptosphaeria maculans interact in a ‘gene for gene’ manner whereby plant resistance (R) genes are complementary to pathogen avirulence (Avr) genes.
McDonald, B., Patrick C Brunner, Anton J Cozijnsen, Barbara J. Howlett, Cozijnsen, Anton J., Brunner, PC, van de Wouw, A.P., Howlett, B.J., Brunner, P., Howlett, BJ, Brunner Patrick C., McDonald, BA, James K. Hane, Oliver, R.P., Angela P Van de Wouw, Richard P. Oliver, Hane, James K., Howlett, Barbara J., Brunner, Patrick C., Oliver, Richard P., Richard P Oliver, Bruce A. McDonald, Angela P. Van de Wouw, Hane, JK, Oliver Richard P., Bruce A McDonald, Anton J. Cozijnsen, Brunner, P.C., Cozijnsen, AJ, Howlett, B., Hane, J., Hane James K., Hane, J.K., Barbara J Howlett, McDonald, Bruce A., van de Wouw, AP, Cozijnsen, A., James K Hane, Cozijnsen Anton J., Howlett Barbara J., McDonald Bruce A., Oliver, Richard, McDonald, B.A., Van de Wouw Angela P., Van de Wouw, Angela P., Patrick C. Brunner, Cozijnsen, A.J., Van de Wouw, A., Oliver, RP   +48 more
core   +1 more source

Parallel loss-of-function at the RPM1 bacterial resistance locus in Arabidopsis thaliana [PDF]

, 2012
Dimorphism at the Resistance to Pseudomonas syringae pv. maculicola 1 (RPM1) locus is well documented in natural populations of Arabidopsis thaliana and has been portrayed as a long-term balanced polymorphism. The haplotype from resistant plants contains
Grant, Murray, Rose, Laura E., Murray Grant, Susanna Atwell, Murray eGrant, Eric B. Holub, Laura Ellen Rose, Holub, E. B., Susanna eAtwell, Laura Rose, Atwell, Susanna, Eric B Holub   +11 more
core   +1 more source