Results 61 to 70 of about 433,979 (304)

The mediating role of negative affect on the relationship between emotional intelligence abilities and aggressive behavior levels [PDF]

, 2018
The aim of the present research aimed to study the mechanisms underlying the relationship between aggressive behaviour and individual levels of ability emotional intelligence (EI).
Cabello-Porras, Maria Rosario, Fernández-Berrocal, Pablo, Gutiérrez-Cobo, María José, Gómez-Leal, Raquel, Megías, Alberto   +4 more
core  

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Dynamics of partisan journalism: journalist-source relations in the context of a local newspaper's anti-paedophile housing agenda [PDF]

, 2006
This article explores the influence of partisanship on the framing of a local news agenda. Using a case study approach, it explores how one local newspaper in the East Midlands of England, the Nottingham-based Evening Post, reacted with hostility to ...
Cross, S, Lockyer, S
core  

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Effects of asenapine on agitation and hostility in adults with acute manic or mixed episodes associated with bipolar I disorder

Neuropsychiatric Disease and Treatment, 2017
Leslie Citrome,1 Ronald Landbloom,2 Cheng-Tao Chang,3 Willie Earley4 1Department of Psychiatry and Behavioral Sciences, New York Medical College, Valhalla, NY, USA; 2Department of Neuroscience, Merck, Whitehouse Station, NJ, USA; 3Biostatistics ...
Citrome L, Landbloom R, Chang C, Earley W   +3 more
doaj  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

A STRANGER: PROJECTION OF ALIENATED FEMALE INDIVIDUALITY IN JEAN RHYS’S SHORT STORIES

Іноземна філологія
The present study examines the prose texts written by Jean Rhys (1890–1979), a British woman writer of modernist literature. It is based on the perusal of several short stories, among others: “In the Rue de l’Arrivée”, “A Night”, “La Grosse Fifi ...
Nadiya Polishchuk
doaj   +1 more source

Indirect aggression use and its experience in penitentiary incarceration [PDF]

Probacja
Introduction: Aim of the research presented in this article is investigation of indirect aggression among inmates. Indirect aggression covers aggressive behaviors toward social position and reputation of the victim, such as ridiculing, disseminating of ...
Krzysztof Nowakowski, Magdalena Przybyła   +1 more
doaj   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source