Results 71 to 80 of about 434,696 (303)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
The mediating role of negative affect on the relationship between emotional intelligence abilities and aggressive behavior levels [PDF]
, 2018 The aim of the present research aimed to study the mechanisms underlying the relationship between aggressive behaviour and individual levels of ability emotional intelligence (EI).
Cabello-Porras, Maria Rosario +4 more
core
Indirect aggression use and its experience in penitentiary incarceration [PDF]
ProbacjaIntroduction: Aim of the research presented in this article is investigation of indirect aggression among inmates. Indirect aggression covers aggressive behaviors toward social position and reputation of the victim, such as ridiculing, disseminating of ...
Krzysztof Nowakowski +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Properly Proleptic Blame [PDF]
, 2017 Crucially, blame can be addressed to its targets, as an implicit demand for recognition. But when we ask whether offenders would actually appreciate this demand, via a sound deliberative route from their existing motivations, we face a puzzle.
Bagley, Benjamin
core +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Reporting the Irish Famine in America: Images of Suffering Ireland in the American Press, 1845-1848 [PDF]
, 2014 This chapter is a study of American newspaper reporting on the Great Irish Famine. The study examines six master narratives that constrained the image of Ireland and the Irish people presented to American readers.
Farrell, James M.
core +1 more source
Contemporary young motherhood: experiences of hostility [PDF]
, 2018 Purpose: The purpose of this paper is to illustrate the hostility many young women who are also mothers experience within their everyday lives. Design/methodology/approach: The paper will draw on qualitative research, incorporating a narrative ...
Department of Education and Skills and Department of Health +1 more
core +1 more source
Neuropsychiatric Disease and Treatment, 2017 Leslie Citrome,1 Ronald Landbloom,2 Cheng-Tao Chang,3 Willie Earley4 1Department of Psychiatry and Behavioral Sciences, New York Medical College, Valhalla, NY, USA; 2Department of Neuroscience, Merck, Whitehouse Station, NJ, USA; 3Biostatistics ...
Citrome L +3 more
doaj
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source