Results 71 to 80 of about 433,979 (304)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Experience of anger in psychological and works of fathers of the church

open access: yesКонсультативная психология и психотерапия, 2011
This paper discusses the scientific understanding of the experience of anger by psychologists and fathers of the Church. The author demonstrates a fundamental difference between the two approaches, including the purposes of exploring anger.
Gavrilova T.P.
doaj  

Moralization and the 2012 U.S. Presidential Election Campaign

open access: yesJournal of Social and Political Psychology, 2015
People vary in the extent to which they imbue an attitude with moral conviction; however, little is known about what makes an issue transform from a relatively non-moral preference to a moral conviction. In the context of the 2012 U.S.
Mark J. Brandt   +2 more
doaj   +1 more source

Evidence based cardiology - Psychosocial factors in the aetiology and prognosis of coronary heart disease: systematic review of prospective cohort studies [PDF]

open access: yes, 1999
Summary points: In healthy populations, prospective cohort studies show a possible aetiological role for type A/hostility (6/14 studies), depression and anxiety (11/11 studies), psychosocial work characteristics (6/10 studies), social support (5/8 ...
Hemingway, H., Marmot, M.
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

'They make us feel like we're a virus': the multiple impacts of Islamophobic hostility towards veiled Muslim women [PDF]

open access: yes, 2015
Within the prevailing post-9/11 climate, veiled Muslim women are commonly portrayed as oppressed, ‘culturally dangerous’ and ‘threatening’ to the western way of life and to notions of public safety and security by virtue of being fully covered in the ...
Chakraborti, N, Zempi, I
core   +2 more sources

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

open access: yesMolecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués   +3 more
wiley   +1 more source

“When in Joburg Relatives Show their True Colours”: 'The changing role of the family as a source of social capital among Zimbabwean migrants in Johannesburg'

open access: yesNordic Journal of Migration Research, 2015
This study analyses the changing role of the family as a source of social capital in aiding migration, settlement and social integration of Zimbabwean migrants.
Chipo Hungwe
doaj   +1 more source

Did perception of the economy affect attitudes to immigration at the 2010 British General Election?* [PDF]

open access: yes, 2015
Objective Immigration and the economy were the most salient issues in British politics at the 2010 general election, yet the relationship between them remains unclear.
Johnson, Craig, Rodger, Sunil
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Home - About - Disclaimer - Privacy